OPENSEQ.org - YCIH - ECOLI GREMLIN

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YCIH - Uncharacterized protein YciH

UniProt:	P08245	Sequence MSDSNSRLVYSTETGRIDEPKAAPVRPKGDGVVRIQRQTSGRKGKGVCLITGVDLDDAELTKLAAELKKKCGCGGAVKDGVIEIQGDKRDLLKSLLEAKGMKVKLAGG	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG11128
Length:	108 (108)
Sequences:	343
Seq/Len:	3.18

YCIH
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
66_E	99_K	3.301	1.00
43_K	46_G	2.832	1.00
36_Q	51_T	2.347	1.00
56_D	59_E	2.25	1.00
49_L	81_V	2.127	1.00
104_K	107_G	2.07	1.00
55_L	59_E	1.978	1.00
35_I	93_K	1.97	1.00
93_K	97_E	1.937	1.00
57_D	61_T	1.691	0.98
35_I	105_L	1.634	0.98
65_A	69_K	1.594	0.98
94_S	98_A	1.574	0.97
70_K	91_L	1.5	0.96
40_S	104_K	1.459	0.95
93_K	105_L	1.453	0.95
48_C	73_C	1.438	0.95
65_A	73_C	1.433	0.95
70_K	95_L	1.419	0.94
69_K	73_C	1.404	0.94
7_R	19_E	1.356	0.92
18_D	22_A	1.302	0.90
55_L	63_L	1.284	0.89
41_G	46_G	1.264	0.88
33_V	103_V	1.237	0.87
37_R	48_C	1.236	0.87
65_A	88_K	1.23	0.86
71_C	84_I	1.19	0.84
35_I	89_R	1.183	0.83
45_K	87_D	1.171	0.82
93_K	103_V	1.165	0.82
19_E	22_A	1.155	0.81
34_R	52_G	1.106	0.77
95_L	99_K	1.104	0.77
64_A	82_I	1.089	0.76
98_A	101_M	1.086	0.75
1_M	4_S	1.082	0.75
36_Q	49_L	1.081	0.75
88_K	91_L	1.064	0.73
39_T	46_G	1.06	0.73
103_V	107_G	1.046	0.71
18_D	21_K	1.043	0.71
73_C	88_K	1.033	0.70
97_E	103_V	1.009	0.67
49_L	62_K	1.004	0.67
53_V	81_V	1.002	0.67

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
1d1rA	1	1	100	0.233	Contact Map	0.317
2if1A	1	0.9352	99.8	0.531	Contact Map	0.373
4kzyl	1	0.9444	99.8	0.548	Contact Map	0.364
2oghA	1	0.9167	99.8	0.559	Contact Map	0.316
4bpeF	1	0.8519	99.8	0.564	Contact Map	0.417
3bf7A	2	0.6944	26.1	0.927	Contact Map	0.09
1ehyA	4	0.8611	15.4	0.934	Contact Map	0.068
1hkhA	2	0.8056	14.1	0.936	Contact Map	0.186
1a8sA	1	0.7685	14.1	0.936	Contact Map	0.157
1a8qA	1	0.7685	14	0.936	Contact Map	0.146

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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