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OPENSEQ.org
ARAA - L-arabinose isomerase
UniProt: P08202 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10052
Length: 500 (499)
Sequences: 574
Seq/Len: 1.15
ARAA
Paralog alert: 0.13 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
264_K 299_Q 4.556 1.00
218_V 285_L 3.33 1.00
227_N 254_L 2.579 1.00
170_K 469_H 2.514 1.00
217_V 269_Q 2.473 0.99
231_D 235_S 2.358 0.99
474_T 489_L 2.226 0.99
434_D 437_T 2.223 0.99
8_E 47_K 2.185 0.98
222_S 225_D 2.124 0.98
411_D 432_Q 2.07 0.97
459_L 475_V 2.031 0.97
488_A 491_W 2.025 0.97
101_L 160_I 2.015 0.97
221_I 261_L 2.011 0.97
145_A 464_Q 1.997 0.97
8_E 49_V 1.965 0.96
409_C 459_L 1.929 0.96
35_V 39_N 1.849 0.94
435_L 439_S 1.844 0.94
487_D 491_W 1.833 0.94
179_C 272_F 1.804 0.93
402_R 472_E 1.801 0.93
481_R 484_A 1.796 0.93
392_I 462_M 1.764 0.92
32_E 36_N 1.76 0.92
120_F 124_N 1.748 0.91
147_V 160_I 1.708 0.90
134_G 443_I 1.706 0.90
17_H 55_T 1.698 0.90
155_Q 436_P 1.693 0.90
485_F 495_Y 1.69 0.89
227_N 231_D 1.68 0.89
247_G 250_R 1.679 0.89
305_G 331_F 1.679 0.89
13_I 31_A 1.668 0.89
261_L 265_R 1.667 0.89
176_L 317_I 1.652 0.88
46_C 74_A 1.631 0.87
154_K 158_E 1.623 0.87
274_A 452_V 1.614 0.86
5_D 487_D 1.609 0.86
484_A 488_A 1.604 0.86
181_F 214_L 1.599 0.86
277_T 303_F 1.591 0.85
474_T 485_F 1.582 0.85
290_G 351_M 1.578 0.85
260_E 295_R 1.576 0.85
322_S 457_L 1.556 0.83
178_V 274_A 1.54 0.83
176_L 274_A 1.532 0.82
9_V 256_A 1.523 0.82
253_V 380_A 1.51 0.81
211_V 281_D 1.508 0.81
286_K 377_D 1.504 0.81
315_L 452_V 1.495 0.80
220_S 223_D 1.493 0.80
330_S 355_C 1.489 0.80
146_V 443_I 1.475 0.79
444_L 486_K 1.472 0.79
318_M 462_M 1.467 0.78
411_D 430_K 1.462 0.78
217_V 265_R 1.46 0.78
173_T 204_F 1.457 0.78
228_A 231_D 1.448 0.77
229_L 232_E 1.446 0.77
407_V 473_I 1.437 0.76
491_W 494_V 1.435 0.76
21_P 25_R 1.43 0.76
409_C 478_N 1.419 0.75
172_D 316_R 1.416 0.75
253_V 368_V 1.414 0.75
47_K 494_V 1.411 0.74
176_L 273_H 1.408 0.74
159_R 440_E 1.406 0.74
465_F 469_H 1.383 0.72
173_T 317_I 1.378 0.72
114_D 417_H 1.373 0.71
218_V 262_G 1.372 0.71
8_E 70_D 1.368 0.71
487_D 490_R 1.367 0.71
12_V 54_G 1.365 0.71
223_D 226_V 1.364 0.71
243_T 253_V 1.354 0.70
29_Q 33_H 1.349 0.69
484_A 491_W 1.342 0.69
45_P 161_G 1.337 0.68
330_S 358_I 1.336 0.68
256_A 366_L 1.331 0.68
395_S 405_L 1.325 0.67
256_A 380_A 1.319 0.67
394_A 462_M 1.317 0.67
175_H 178_V 1.314 0.67
490_R 495_Y 1.314 0.67
110_A 340_E 1.313 0.66
485_F 492_N 1.312 0.66
441_A 482_L 1.305 0.66
246_H 250_R 1.3 0.65
36_N 40_T 1.298 0.65
386_T 427_A 1.296 0.65
238_T 365_I 1.293 0.65
215_V 284_G 1.29 0.64
367_D 383_I 1.288 0.64
340_E 343_N 1.288 0.64
482_L 486_K 1.284 0.64
155_Q 392_I 1.283 0.64
228_A 232_E 1.281 0.64
192_D 349_S 1.279 0.63
9_V 74_A 1.279 0.63
484_A 494_V 1.276 0.63
212_G 283_H 1.272 0.63
9_V 46_C 1.27 0.63
225_D 265_R 1.269 0.63
33_H 152_Q 1.269 0.63
225_D 228_A 1.256 0.61
397_I 448_A 1.255 0.61
375_G 379_P 1.25 0.61
36_N 39_N 1.243 0.60
432_Q 478_N 1.243 0.60
479_D 484_A 1.234 0.59
233_Y 295_R 1.233 0.59
305_G 351_M 1.222 0.58
440_E 444_L 1.221 0.58
484_A 487_D 1.22 0.58
162_S 461_D 1.219 0.58
185_M 279_F 1.217 0.58
481_R 485_F 1.217 0.58
290_G 305_G 1.212 0.57
494_V 497_G 1.212 0.57
70_D 235_S 1.209 0.57
492_N 496_Y 1.206 0.57
41_E 157_H 1.202 0.56
8_E 72_R 1.2 0.56
154_K 269_Q 1.191 0.55
238_T 363_K 1.189 0.55
467_E 486_K 1.186 0.55
497_G 500_R 1.181 0.54
33_H 37_A 1.178 0.54
232_E 299_Q 1.174 0.54
484_A 500_R 1.172 0.54
395_S 448_A 1.171 0.53
109_A 340_E 1.171 0.53
340_E 344_D 1.168 0.53
35_V 48_L 1.163 0.53
155_Q 158_E 1.162 0.53
187_E 280_E 1.162 0.53
5_D 488_A 1.158 0.52
298_Q 355_C 1.158 0.52
265_R 269_Q 1.157 0.52
7_Y 74_A 1.155 0.52
12_V 63_I 1.149 0.51
234_E 250_R 1.147 0.51
177_K 271_G 1.146 0.51
231_D 234_E 1.145 0.51
393_V 410_I 1.143 0.51
9_V 164_M 1.141 0.51
61_T 65_R 1.141 0.51
196_V 331_F 1.135 0.50
478_N 494_V 1.131 0.50
44_L 48_L 1.126 0.49
65_R 69_Y 1.119 0.48
404_R 472_E 1.117 0.48
267_L 275_F 1.116 0.48
159_R 486_K 1.114 0.48
487_D 495_Y 1.111 0.48
158_E 227_N 1.105 0.47
234_E 245_I 1.101 0.47
36_N 268_E 1.096 0.46
479_D 494_V 1.094 0.46
233_Y 260_E 1.093 0.46
487_D 500_R 1.093 0.46
108_N 120_F 1.088 0.45
138_A 168_V 1.087 0.45
143_Q 406_L 1.087 0.45
175_H 273_H 1.085 0.45
418_S 465_F 1.085 0.45
345_L 413_V 1.084 0.45
172_D 274_A 1.079 0.45
250_R 254_L 1.074 0.44
179_C 270_G 1.074 0.44
141_R 497_G 1.074 0.44
463_R 475_V 1.067 0.43
110_A 338_H 1.065 0.43
208_T 278_T 1.062 0.43
93_L 137_G 1.056 0.42
28_T 32_E 1.055 0.42
263_M 292_A 1.053 0.42
170_K 174_R 1.051 0.42
213_D 270_G 1.05 0.42
179_C 208_T 1.049 0.42
62_A 65_R 1.048 0.42
6_N 484_A 1.043 0.41
491_W 497_G 1.041 0.41
459_L 483_P 1.04 0.41
153_D 462_M 1.039 0.41
207_N 272_F 1.037 0.41
4_F 323_T 1.036 0.41
345_L 430_K 1.036 0.41
390_P 411_D 1.035 0.40
444_L 467_E 1.035 0.40
171_Q 175_H 1.034 0.40
204_F 313_A 1.031 0.40
493_E 499_R 1.029 0.40
76_L 100_L 1.029 0.40
56_T 62_A 1.029 0.40
7_Y 491_W 1.025 0.40
250_R 499_R 1.025 0.40
345_L 416_P 1.021 0.39
78_V 133_F 1.017 0.39
25_R 475_V 1.015 0.39
9_V 465_F 1.015 0.39
486_K 493_E 1.014 0.39
225_D 427_A 1.014 0.39
128_H 449_H 1.013 0.38
463_R 483_P 1.013 0.38
56_T 59_E 1.013 0.38
73_C 76_L 1.012 0.38
264_K 298_Q 1.012 0.38
487_D 492_N 1.011 0.38
179_C 209_W 1.009 0.38
314_L 394_A 1.007 0.38
76_L 349_S 1.005 0.38
64_C 96_L 1.004 0.38
477_D 483_P 1.003 0.38
7_Y 171_Q 1.003 0.38
491_W 498_F 1.002 0.37
230_V 257_A 1 0.37
323_T 484_A 1 0.37
293_V 303_F 1 0.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f2dA30.9981000.085Contact Map0.623
1fuiA60.941000.397Contact Map0.396
3a9sA30.9421000.429Contact Map0.482
3rotA20.56292.40.959Contact Map0.511
3brqA20.49890.20.961Contact Map0.401
3dbiA30.48289.60.962Contact Map0.425
3k4hA20.5187.20.963Contact Map0.309
1dbqA20.51860.964Contact Map0.402
3l6uA20.492850.964Contact Map0.462
2x7xA20.52684.30.965Contact Map0.399
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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