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OPENSEQ.org
FOLC - Bifunctional protein FolC
UniProt: P08192 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10327
Length: 422 (403)
Sequences: 5827
Seq/Len: 14.46
FOLC
Paralog alert: 0.92 [within 20: 0.29] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
165_V 264_A 4.814 1.00
70_I 265_L 3.395 1.00
328_A 349_V 3.094 1.00
180_D 183_S 2.996 1.00
90_T 102_E 2.989 1.00
380_S 383_Q 2.983 1.00
54_V 64_C 2.914 1.00
335_D 362_G 2.79 1.00
179_P 183_S 2.738 1.00
170_A 308_H 2.712 1.00
163_V 264_A 2.687 1.00
165_V 260_T 2.667 1.00
48_A 136_K 2.515 1.00
192_F 198_A 2.444 1.00
73_A 283_S 2.382 1.00
291_Q 411_M 2.336 1.00
325_R 396_D 2.325 1.00
133_W 137_Q 2.294 1.00
392_A 398_V 2.272 1.00
273_S 276_A 2.244 1.00
152_R 187_E 2.206 1.00
76_Y 141_D 2.129 1.00
171_L 174_T 2.114 1.00
248_L 258_A 2.112 1.00
67_L 264_A 2.09 1.00
79_G 135_F 2.036 1.00
67_L 265_L 2.029 1.00
71_L 142_V 2.028 1.00
68_E 72_M 2.021 1.00
171_L 339_A 1.958 1.00
223_R 260_T 1.951 1.00
57_T 172_D 1.889 1.00
378_F 387_A 1.881 1.00
332_M 341_T 1.871 1.00
327_L 391_D 1.863 1.00
64_C 80_V 1.838 1.00
63_T 167_T 1.835 1.00
69_S 280_G 1.829 1.00
53_T 147_V 1.828 1.00
58_N 309_A 1.824 1.00
54_V 67_L 1.824 1.00
50_F 162_D 1.813 1.00
387_A 391_D 1.806 1.00
376_K 387_A 1.79 1.00
335_D 361_R 1.77 1.00
37_L 41_R 1.763 1.00
313_L 399_L 1.762 1.00
262_L 277_I 1.758 1.00
51_V 156_T 1.756 1.00
163_V 199_I 1.741 1.00
212_V 216_K 1.73 1.00
303_V 404_F 1.729 1.00
100_L 134_L 1.721 1.00
378_F 383_Q 1.701 1.00
351_D 376_K 1.695 1.00
74_A 272_V 1.693 1.00
327_L 353_Y 1.68 1.00
221_Q 267_A 1.666 1.00
327_L 351_D 1.646 1.00
337_D 340_G 1.646 1.00
212_V 215_E 1.627 1.00
199_I 267_A 1.626 1.00
111_E 137_Q 1.623 1.00
73_A 279_D 1.608 1.00
52_F 268_S 1.604 1.00
55_A 147_V 1.603 1.00
104_A 138_A 1.603 1.00
342_L 372_L 1.601 1.00
290_F 300_I 1.597 1.00
182_E 206_P 1.595 1.00
325_R 351_D 1.582 1.00
236_W 255_Q 1.549 1.00
183_S 186_R 1.548 1.00
353_Y 391_D 1.546 1.00
68_E 94_R 1.544 1.00
63_T 261_A 1.539 1.00
66_T 258_A 1.536 1.00
207_S 211_D 1.536 1.00
343_A 347_S 1.535 1.00
44_V 47_P 1.529 1.00
88_R 102_E 1.525 1.00
58_N 306_N 1.523 1.00
67_L 261_A 1.499 1.00
387_A 390_A 1.475 1.00
73_A 280_G 1.473 1.00
247_N 282_A 1.47 1.00
258_A 281_I 1.468 1.00
70_I 280_G 1.451 1.00
329_V 398_V 1.448 1.00
74_A 276_A 1.447 1.00
356_P 365_A 1.443 1.00
185_G 208_T 1.439 1.00
292_I 300_I 1.432 1.00
292_I 298_R 1.43 1.00
62_T 254_P 1.425 1.00
151_G 154_D 1.425 1.00
227_W 263_A 1.412 1.00
186_R 212_V 1.411 1.00
150_G 176_W 1.41 1.00
67_L 144_I 1.406 0.99
58_N 308_H 1.402 0.99
288_G 407_V 1.394 0.99
311_E 315_G 1.387 0.99
88_R 99_E 1.385 0.99
367_Q 370_E 1.384 0.99
89_Y 127_G 1.38 0.99
235_D 247_N 1.376 0.99
325_R 350_D 1.362 0.99
39_A 158_I 1.36 0.99
166_V 192_F 1.357 0.99
67_L 165_V 1.354 0.99
237_A 245_L 1.344 0.99
364_T 367_Q 1.342 0.99
278_R 282_A 1.34 0.99
71_L 144_I 1.34 0.99
178_G 183_S 1.328 0.99
329_V 388_A 1.318 0.99
63_T 165_V 1.315 0.99
147_V 153_L 1.315 0.99
77_K 96_Q 1.302 0.99
64_C 144_I 1.298 0.99
353_Y 387_A 1.297 0.99
275_N 279_D 1.294 0.99
71_L 268_S 1.29 0.99
351_D 391_D 1.29 0.99
312_Y 315_G 1.284 0.99
62_T 66_T 1.281 0.99
311_E 347_S 1.258 0.99
338_I 371_H 1.255 0.99
50_F 142_V 1.251 0.99
145_L 159_V 1.237 0.98
74_A 280_G 1.234 0.98
269_G 273_S 1.231 0.98
327_L 396_D 1.221 0.98
329_V 400_V 1.209 0.98
274_E 278_R 1.209 0.98
87_V 408_A 1.206 0.98
366_E 370_E 1.203 0.98
111_E 133_W 1.2 0.98
37_L 40_A 1.199 0.98
38_V 129_L 1.198 0.98
279_D 283_S 1.197 0.98
101_P 104_A 1.194 0.98
317_M 326_V 1.191 0.98
69_S 283_S 1.188 0.98
125_E 128_T 1.186 0.98
89_Y 105_H 1.178 0.98
149_L 176_W 1.163 0.97
76_Y 142_V 1.159 0.97
189_A 212_V 1.158 0.97
308_H 312_Y 1.157 0.97
189_A 209_I 1.153 0.97
163_V 268_S 1.15 0.97
198_A 218_A 1.15 0.97
38_V 121_L 1.145 0.97
66_T 284_A 1.142 0.97
228_N 239_S 1.139 0.97
236_W 258_A 1.139 0.97
244_T 278_R 1.136 0.97
315_G 348_V 1.131 0.97
238_F 262_L 1.13 0.97
200_V 209_I 1.13 0.97
168_S 203_P 1.13 0.97
187_E 190_G 1.129 0.97
197_P 267_A 1.129 0.97
51_V 143_V 1.129 0.97
70_I 277_I 1.129 0.97
104_A 107_A 1.125 0.97
171_L 181_R 1.116 0.96
87_V 411_M 1.11 0.96
353_Y 378_F 1.11 0.96
310_A 401_C 1.107 0.96
52_F 67_L 1.105 0.96
90_T 99_E 1.1 0.96
354_C 372_L 1.098 0.96
162_D 196_K 1.095 0.96
321_P 397_T 1.093 0.96
310_A 314_T 1.09 0.96
79_G 140_L 1.088 0.96
130_S 156_T 1.088 0.96
370_E 373_G 1.083 0.96
70_I 261_A 1.077 0.95
78_V 144_I 1.076 0.95
290_F 316_R 1.075 0.95
132_L 145_L 1.068 0.95
310_A 344_W 1.066 0.95
169_I 185_G 1.059 0.95
317_M 399_L 1.054 0.95
182_E 208_T 1.051 0.94
85_H 92_R 1.049 0.94
112_I 115_A 1.049 0.94
376_K 391_D 1.048 0.94
277_I 280_G 1.045 0.94
386_D 390_A 1.043 0.94
21_E 123_Y 1.037 0.94
311_E 344_W 1.034 0.94
81_Y 128_T 1.028 0.94
344_W 347_S 1.022 0.93
299_V 389_M 1.022 0.93
383_Q 386_D 1.022 0.93
51_V 145_L 1.02 0.93
258_A 280_G 1.02 0.93
66_T 250_L 1.017 0.93
52_F 264_A 1.017 0.93
163_V 267_A 1.016 0.93
72_M 96_Q 1.014 0.93
164_A 196_K 1.011 0.93
310_A 341_T 1.01 0.93
330_I 372_L 1.007 0.93
276_A 280_G 1.004 0.93
185_G 206_P 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1jbwA10.96211000.178Contact Map0.743
2vosA10.99291000.183Contact Map0.758
3nrsA10.9811000.207Contact Map0.791
1w78A10.99291000.211Contact Map0.713
1o5zA10.98581000.212Contact Map0.783
4c12A10.91711000.409Contact Map0.806
4bubA20.90521000.413Contact Map0.784
1e8cA20.91471000.424Contact Map0.772
2wtzA40.90761000.435Contact Map0.747
3zl8A10.86491000.448Contact Map0.684
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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