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OPENSEQ.org
CHEB - Chemotaxis response regulator protein-glutamate methylesterase
UniProt: P07330 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10147
Length: 349 (341)
Sequences: 1699
Seq/Len: 4.98
CHEB
Paralog alert: 0.35 [within 20: 0.03] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
312_F 319_I 5.371 1.00
294_M 299_A 3.886 1.00
160_A 267_V 3.612 1.00
209_I 225_A 3.425 1.00
26_H 128_R 3.366 1.00
162_G 260_V 3.129 1.00
23_I 29_M 3.043 1.00
292_L 296_Q 2.984 1.00
28_D 128_R 2.967 1.00
326_E 336_Q 2.952 1.00
37_D 61_R 2.842 1.00
302_L 333_V 2.841 1.00
212_K 215_E 2.803 1.00
63_D 66_D 2.713 1.00
234_M 245_I 2.624 1.00
33_A 48_F 2.589 1.00
295_R 325_C 2.588 1.00
204_N 210_G 2.518 1.00
191_M 196_T 2.49 1.00
303_A 319_I 2.469 1.00
303_A 324_V 2.443 1.00
319_I 327_V 2.347 1.00
277_G 294_M 2.203 1.00
265_H 293_A 2.197 1.00
216_D 246_K 2.166 1.00
23_I 127_V 2.153 1.00
316_R 320_N 2.139 1.00
212_K 218_E 2.132 1.00
175_L 207_C 2.108 1.00
161_I 174_V 2.092 1.00
29_M 127_V 2.05 1.00
72_M 76_P 2.026 1.00
232_R 249_D 2.024 1.00
291_M 301_T 2.021 1.00
218_E 226_Y 1.987 1.00
249_D 257_R 1.973 1.00
9_V 41_A 1.969 1.00
39_L 61_R 1.941 1.00
42_R 67_F 1.91 1.00
305_N 309_C 1.889 1.00
317_E 320_N 1.881 1.00
226_Y 245_I 1.877 1.00
328_V 333_V 1.856 1.00
303_A 327_V 1.855 1.00
237_S 246_K 1.831 1.00
5_R 30_E 1.823 1.00
163_A 280_L 1.794 1.00
318_A 324_V 1.769 1.00
304_Q 309_C 1.762 1.00
212_K 224_H 1.693 0.99
312_F 316_R 1.683 0.99
53_L 77_M 1.668 0.99
57_V 81_M 1.632 0.99
288_A 323_G 1.629 0.99
20_T 34_T 1.611 0.99
103_D 126_K 1.586 0.99
291_M 323_G 1.551 0.99
288_A 321_M 1.549 0.99
196_T 213_E 1.539 0.99
301_T 318_A 1.537 0.99
90_S 93_T 1.534 0.99
301_T 323_G 1.528 0.99
304_Q 307_A 1.519 0.99
210_G 224_H 1.518 0.99
55_L 67_F 1.511 0.99
292_L 323_G 1.511 0.99
308_S 329_D 1.51 0.99
197_R 201_D 1.498 0.98
336_Q 339_A 1.489 0.98
102_I 130_A 1.485 0.98
158_L 186_L 1.478 0.98
318_A 323_G 1.478 0.98
68_L 79_V 1.478 0.98
91_E 95_R 1.478 0.98
36_P 40_V 1.477 0.98
8_S 19_M 1.469 0.98
80_V 130_A 1.464 0.98
308_S 331_S 1.457 0.98
186_L 220_V 1.447 0.98
173_H 331_S 1.446 0.98
279_I 291_M 1.444 0.98
267_V 275_A 1.44 0.98
187_I 225_A 1.436 0.98
184_A 220_V 1.427 0.98
62_M 66_D 1.424 0.98
81_M 86_T 1.414 0.98
170_A 330_L 1.406 0.97
69_E 99_L 1.391 0.97
312_F 327_V 1.386 0.97
95_R 99_L 1.375 0.97
309_C 312_F 1.363 0.97
174_V 280_L 1.362 0.97
329_D 332_Q 1.362 0.97
305_N 329_D 1.357 0.97
46_K 74_L 1.344 0.96
303_A 312_F 1.332 0.96
291_M 318_A 1.326 0.96
300_W 325_C 1.304 0.96
261_D 290_G 1.287 0.95
256_H 259_S 1.282 0.95
43_D 47_K 1.271 0.95
45_I 53_L 1.264 0.94
221_L 224_H 1.254 0.94
279_I 301_T 1.25 0.94
57_V 92_V 1.25 0.94
188_T 263_L 1.249 0.94
235_E 248_H 1.245 0.94
288_A 318_A 1.242 0.94
253_V 265_H 1.226 0.93
6_V 52_V 1.213 0.93
275_A 294_M 1.21 0.93
33_A 50_P 1.208 0.92
324_V 327_V 1.202 0.92
243_Y 271_A 1.2 0.92
291_M 321_M 1.192 0.92
43_D 46_K 1.186 0.92
187_I 227_I 1.176 0.91
86_T 89_G 1.172 0.91
301_T 321_M 1.167 0.91
186_L 234_M 1.153 0.90
159_I 337_M 1.139 0.89
220_V 236_L 1.135 0.89
293_A 296_Q 1.128 0.89
179_P 338_L 1.126 0.89
288_A 317_E 1.12 0.88
115_G 118_A 1.11 0.88
174_V 333_V 1.107 0.87
55_L 68_L 1.1 0.87
186_L 245_I 1.097 0.87
201_D 204_N 1.096 0.87
292_L 321_M 1.077 0.85
64_G 107_K 1.074 0.85
279_I 324_V 1.073 0.85
80_V 102_I 1.072 0.85
38_P 67_F 1.066 0.85
174_V 337_M 1.06 0.84
291_M 324_V 1.059 0.84
70_K 73_R 1.055 0.84
69_E 95_R 1.052 0.84
192_P 230_G 1.05 0.83
49_N 75_R 1.05 0.83
29_M 128_R 1.044 0.83
212_K 226_Y 1.037 0.82
87_G 106_T 1.037 0.82
177_P 335_Q 1.032 0.82
56_D 64_G 1.025 0.81
59_M 64_G 1.023 0.81
44_L 47_K 1.015 0.80
163_A 171_I 1.014 0.80
56_D 107_K 1.011 0.80
35_A 44_L 1.01 0.80
42_R 45_I 1.005 0.79
11_D 59_M 1.005 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1a2oA211000.194Contact Map0.865
1chdA10.58171000.429Contact Map0.851
3sftA10.55011000.441Contact Map0.867
4l4uA10.9571000.569Contact Map0.377
1ny5A20.86821000.572Contact Map0.419
3dzdA20.83951000.587Contact Map0.389
3n0rA10.366899.90.772Contact Map0.487
3eq2A20.879799.90.79Contact Map0.602
2ayxA10.363999.80.793Contact Map0.404
1dz3A10.363999.80.794Contact Map0.542
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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