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OPENSEQ.org
SDIA - Regulatory protein SdiA
UniProt: P07026 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10935
Length: 240 (229)
Sequences: 772
Seq/Len: 3.37
SDIA
Paralog alert: 0.26 [within 20: 0.03] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
195_K 203_I 4.724 1.00
190_W 195_K 3.392 1.00
190_W 203_I 2.777 1.00
184_E 221_K 2.642 1.00
197_S 212_N 2.568 1.00
197_S 227_K 2.425 1.00
71_Y 80_D 2.378 1.00
196_T 199_E 2.365 1.00
213_F 217_N 2.324 1.00
44_L 162_L 2.228 1.00
95_W 118_G 2.034 1.00
70_Y 76_F 2.013 1.00
71_Y 110_A 1.968 1.00
188_L 230_V 1.859 0.99
209_N 216_K 1.851 0.99
67_W 71_Y 1.824 0.99
76_F 109_A 1.816 0.99
67_W 110_A 1.808 0.99
22_T 25_E 1.804 0.99
67_W 76_F 1.79 0.99
187_I 227_K 1.78 0.99
187_I 218_M 1.779 0.99
198_A 201_A 1.758 0.99
215_Q 218_M 1.752 0.99
183_R 186_E 1.645 0.98
222_I 230_V 1.614 0.98
67_W 95_W 1.612 0.98
219_Q 226_N 1.61 0.98
219_Q 227_K 1.594 0.98
67_W 80_D 1.577 0.98
70_Y 109_A 1.544 0.97
164_A 167_R 1.492 0.96
110_A 113_H 1.481 0.96
209_N 214_H 1.456 0.96
63_Y 67_W 1.431 0.95
195_K 199_E 1.422 0.95
93_L 124_M 1.415 0.95
129_A 226_N 1.411 0.95
198_A 202_M 1.394 0.94
183_R 210_T 1.368 0.93
191_T 227_K 1.36 0.93
233_Y 236_A 1.356 0.93
214_H 217_N 1.355 0.93
69_S 73_A 1.336 0.92
125_L 129_A 1.331 0.92
108_E 112_A 1.308 0.91
81_P 134_S 1.303 0.91
199_E 203_I 1.297 0.91
76_F 79_I 1.283 0.90
198_A 208_E 1.276 0.90
224_A 230_V 1.276 0.90
71_Y 76_F 1.274 0.90
44_L 131_G 1.268 0.89
64_P 115_L 1.246 0.88
208_E 212_N 1.243 0.88
212_N 227_K 1.239 0.88
228_T 231_A 1.226 0.87
233_Y 237_T 1.224 0.87
198_A 227_K 1.22 0.87
187_I 215_Q 1.22 0.87
80_D 110_A 1.22 0.87
195_K 198_A 1.213 0.86
186_E 203_I 1.204 0.86
121_Q 215_Q 1.203 0.86
67_W 118_G 1.188 0.85
226_N 229_Q 1.183 0.85
120_T 189_R 1.175 0.84
25_E 28_H 1.172 0.84
209_N 213_F 1.172 0.84
224_A 229_Q 1.159 0.83
115_L 227_K 1.152 0.82
95_W 120_T 1.147 0.82
187_I 204_L 1.139 0.81
212_N 216_K 1.118 0.80
158_V 162_L 1.106 0.79
45_C 82_V 1.089 0.77
71_Y 83_L 1.088 0.77
67_W 82_V 1.088 0.77
68_V 132_F 1.084 0.77
120_T 132_F 1.083 0.77
81_P 118_G 1.075 0.76
43_S 115_L 1.075 0.76
83_L 132_F 1.073 0.76
201_A 208_E 1.07 0.75
34_A 135_F 1.07 0.75
131_G 197_S 1.065 0.75
229_Q 232_C 1.064 0.75
186_E 190_W 1.061 0.75
86_E 93_L 1.05 0.73
184_E 217_N 1.05 0.73
71_Y 79_I 1.044 0.73
38_E 196_T 1.036 0.72
190_W 198_A 1.034 0.72
190_W 196_T 1.03 0.71
35_Q 201_A 1.029 0.71
218_M 231_A 1.026 0.71
67_W 134_S 1.025 0.71
223_N 233_Y 1.022 0.71
63_Y 136_S 1.02 0.70
63_Y 120_T 1.017 0.70
197_S 219_Q 1.016 0.70
82_V 120_T 1.014 0.70
28_H 112_A 1.002 0.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1l3lA40.951000.298Contact Map0.616
2q0oA20.95831000.299Contact Map0.618
3sztA20.97921000.304Contact Map0.613
3qp6A10.97081000.345Contact Map0.588
2avxA10.71251000.523Contact Map0.471
3ix3A20.70421000.562Contact Map0.537
3qp1A10.670899.90.576Contact Map0.549
3cloA30.9599.90.65Contact Map0.511
3ulqB10.37599.50.751Contact Map0.714
3c57A20.354299.50.753Contact Map0.608
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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