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OPENSEQ.org
MALT - HTH-type transcriptional regulator MalT
UniProt: P06993 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10562
Length: 901 (868)
Sequences: 2632
Seq/Len: 3.03
MALT
Paralog alert: 0.30 [within 20: 0.06] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
624_D 627_N 6.18 1.00
665_D 668_A 5.953 1.00
585_R 588_E 5.276 1.00
743_R 746_D 5.04 1.00
49_I 158_L 4.831 1.00
543_F 546_T 4.642 1.00
464_N 467_E 4.565 1.00
424_R 427_E 4.51 1.00
503_E 506_R 4.251 1.00
344_H 363_H 3.934 1.00
191_A 222_L 3.91 1.00
703_E 706_P 3.901 1.00
277_L 347_A 3.219 1.00
871_I 875_Y 2.994 1.00
839_R 842_Q 2.983 1.00
130_Y 157_V 2.952 1.00
264_D 300_E 2.842 1.00
847_I 856_I 2.733 1.00
590_E 622_R 2.632 1.00
211_I 222_L 2.621 1.00
535_S 551_Q 2.527 1.00
47_T 51_Q 2.518 1.00
195_F 226_A 2.465 1.00
188_H 209_S 2.442 1.00
39_S 43_Y 2.434 1.00
274_S 320_Y 2.391 1.00
187_T 190_E 2.361 1.00
348_A 364_A 2.301 1.00
844_L 886_A 2.3 1.00
851_Y 859_E 2.226 1.00
128_D 158_L 2.21 1.00
840_E 877_K 2.195 1.00
731_L 753_D 2.18 1.00
865_T 872_R 2.144 1.00
538_L 543_F 2.128 1.00
191_A 212_C 2.074 1.00
508_L 541_Q 2.055 1.00
275_A 329_R 2.048 1.00
267_T 300_E 2.046 1.00
594_R 615_L 2.031 1.00
495_G 511_M 2.02 1.00
844_L 874_L 2.007 1.00
171_R 178_E 1.993 1.00
37_I 49_I 1.984 1.00
49_I 126_V 1.984 1.00
841_W 845_G 1.933 0.99
134_T 137_V 1.927 0.99
712_E 734_L 1.902 0.99
616_I 632_L 1.886 0.99
508_L 534_Q 1.866 0.99
53_A 126_V 1.86 0.99
708_E 743_R 1.852 0.99
719_R 753_D 1.838 0.99
619_S 624_D 1.832 0.99
548_W 576_R 1.831 0.99
429_N 433_A 1.831 0.99
456_A 472_A 1.825 0.99
559_N 595_S 1.816 0.99
619_S 631_Q 1.8 0.99
519_R 553_K 1.782 0.99
590_E 594_R 1.78 0.99
844_L 890_A 1.77 0.99
26_L 52_W 1.754 0.99
548_W 583_W 1.71 0.98
664_G 669_A 1.699 0.98
580_L 585_R 1.694 0.98
16_T 47_T 1.687 0.98
738_Y 746_D 1.68 0.98
708_E 712_E 1.671 0.98
264_D 267_T 1.661 0.98
512_Q 534_Q 1.661 0.98
267_T 301_I 1.653 0.98
548_W 552_E 1.65 0.98
276_I 343_I 1.647 0.98
128_D 131_H 1.645 0.98
660_W 668_A 1.644 0.98
619_S 627_N 1.642 0.98
467_E 470_R 1.642 0.98
872_R 876_Q 1.641 0.98
719_R 727_L 1.64 0.98
57_N 124_Y 1.639 0.98
508_L 512_Q 1.639 0.98
146_I 155_L 1.637 0.98
345_R 349_E 1.629 0.98
660_W 665_D 1.629 0.98
869_T 873_N 1.621 0.98
715_N 734_L 1.62 0.98
734_L 738_Y 1.618 0.98
252_S 330_Q 1.617 0.98
449_A 475_A 1.616 0.98
40_P 43_Y 1.598 0.97
123_L 153_L 1.585 0.97
872_R 875_Y 1.578 0.97
130_Y 139_H 1.574 0.97
728_N 754_A 1.568 0.97
272_L 339_E 1.565 0.97
50_S 61_W 1.563 0.97
862_V 867_I 1.551 0.97
415_Q 419_M 1.542 0.97
20_E 190_E 1.532 0.96
633_N 668_A 1.528 0.96
345_R 369_D 1.525 0.96
190_E 193_Q 1.523 0.96
276_I 329_R 1.52 0.96
731_L 750_V 1.514 0.96
579_L 583_W 1.501 0.96
738_Y 743_R 1.5 0.96
629_R 663_T 1.493 0.96
419_M 427_E 1.492 0.96
552_E 576_R 1.488 0.95
731_L 757_L 1.48 0.95
210_R 214_D 1.479 0.95
633_N 637_N 1.466 0.95
612_L 631_Q 1.461 0.95
149_Q 153_L 1.46 0.95
708_E 741_A 1.46 0.95
865_T 869_T 1.458 0.95
587_D 622_R 1.436 0.94
419_M 424_R 1.435 0.94
629_R 656_R 1.434 0.94
436_E 455_R 1.434 0.94
273_K 347_A 1.433 0.94
715_N 730_N 1.432 0.94
850_G 853_N 1.43 0.94
843_V 870_H 1.429 0.94
495_G 507_S 1.428 0.94
41_A 160_R 1.426 0.94
615_L 631_Q 1.425 0.94
554_A 572_L 1.422 0.94
849_S 859_E 1.407 0.93
868_K 872_R 1.406 0.93
586_L 622_R 1.399 0.93
224_L 259_V 1.399 0.93
531_L 553_K 1.393 0.93
847_I 853_N 1.392 0.93
389_E 392_L 1.392 0.93
867_I 871_I 1.391 0.93
633_N 656_R 1.387 0.93
695_A 711_L 1.385 0.93
51_Q 54_A 1.381 0.93
19_R 22_L 1.38 0.93
26_L 35_A 1.379 0.92
416_A 432_L 1.378 0.92
555_F 569_H 1.378 0.92
853_N 883_R 1.377 0.92
748_Q 752_L 1.374 0.92
580_L 592_S 1.373 0.92
125_L 155_L 1.368 0.92
698_Q 706_P 1.367 0.92
364_A 372_M 1.365 0.92
854_E 864_A 1.363 0.92
329_R 340_L 1.363 0.92
753_D 757_L 1.359 0.92
627_N 631_Q 1.355 0.92
352_M 372_M 1.355 0.92
306_L 324_F 1.355 0.92
188_H 192_K 1.352 0.91
27_S 55_G 1.35 0.91
195_F 208_S 1.349 0.91
208_S 212_C 1.344 0.91
342_E 346_A 1.342 0.91
854_E 869_T 1.34 0.91
535_S 550_T 1.339 0.91
556_Q 559_N 1.339 0.91
538_L 550_T 1.326 0.90
862_V 865_T 1.323 0.90
518_A 530_S 1.318 0.90
843_V 877_K 1.317 0.90
325_G 329_R 1.316 0.90
58_D 121_S 1.314 0.90
881_A 885_D 1.312 0.90
873_N 876_Q 1.309 0.90
738_Y 750_V 1.308 0.90
847_I 865_T 1.306 0.90
847_I 871_I 1.306 0.90
336_L 339_E 1.303 0.89
52_W 156_V 1.303 0.89
269_H 339_E 1.302 0.89
728_N 758_A 1.302 0.89
263_V 267_T 1.299 0.89
144_F 148_H 1.296 0.89
618_C 622_R 1.294 0.89
846_L 853_N 1.292 0.89
209_S 213_D 1.289 0.89
551_Q 579_L 1.282 0.88
708_E 734_L 1.281 0.88
548_W 579_L 1.281 0.88
889_H 892_Q 1.279 0.88
548_W 585_R 1.277 0.88
875_Y 880_V 1.271 0.88
844_L 880_V 1.271 0.88
670_A 674_R 1.269 0.88
75_A 78_L 1.262 0.87
332_C 336_L 1.255 0.87
49_I 53_A 1.252 0.87
268_R 272_L 1.252 0.87
419_M 428_V 1.249 0.87
847_I 886_A 1.247 0.86
840_E 843_V 1.247 0.86
695_A 714_L 1.245 0.86
758_A 767_F 1.24 0.86
42_G 45_K 1.233 0.86
589_A 618_C 1.227 0.85
444_E 447_M 1.226 0.85
126_V 158_L 1.222 0.85
735_N 751_L 1.222 0.85
847_I 887_V 1.22 0.85
519_R 527_A 1.216 0.84
576_R 580_L 1.216 0.84
880_V 886_A 1.213 0.84
661_Q 669_A 1.212 0.84
747_A 754_A 1.212 0.84
636_E 656_R 1.204 0.84
322_P 326_N 1.204 0.84
130_Y 133_I 1.203 0.84
186_F 190_E 1.202 0.84
843_V 846_L 1.202 0.84
53_A 124_Y 1.197 0.83
22_L 35_A 1.194 0.83
23_L 26_L 1.191 0.83
847_I 874_L 1.19 0.83
329_R 344_H 1.188 0.83
144_F 147_R 1.187 0.82
708_E 737_L 1.184 0.82
871_I 886_A 1.183 0.82
286_T 294_G 1.182 0.82
498_L 503_E 1.18 0.82
133_I 139_H 1.177 0.82
577_A 593_A 1.176 0.82
588_E 592_S 1.176 0.82
18_V 22_L 1.176 0.82
881_A 884_Q 1.173 0.81
51_Q 55_G 1.169 0.81
369_D 372_M 1.168 0.81
844_L 847_I 1.166 0.81
154_T 224_L 1.165 0.81
576_R 592_S 1.162 0.81
629_R 665_D 1.161 0.81
274_S 285_I 1.16 0.80
869_T 872_R 1.16 0.80
865_T 868_K 1.158 0.80
128_D 322_P 1.154 0.80
844_L 868_K 1.153 0.80
886_A 890_A 1.153 0.80
159_S 163_P 1.153 0.80
597_I 615_L 1.153 0.80
746_D 749_R 1.15 0.80
552_E 588_E 1.149 0.80
728_N 763_F 1.148 0.79
22_L 48_L 1.148 0.79
212_C 215_V 1.146 0.79
746_D 750_V 1.145 0.79
877_K 883_R 1.142 0.79
27_S 52_W 1.139 0.79
711_L 733_L 1.138 0.79
215_V 225_I 1.138 0.79
38_T 159_S 1.136 0.79
694_I 698_Q 1.134 0.78
851_Y 857_A 1.133 0.78
360_A 363_H 1.131 0.78
43_Y 219_A 1.13 0.78
868_K 876_Q 1.129 0.78
593_A 618_C 1.127 0.78
270_F 274_S 1.127 0.78
270_F 294_G 1.126 0.78
191_A 226_A 1.126 0.78
58_D 123_L 1.125 0.78
697_A 701_L 1.125 0.78
537_I 541_Q 1.125 0.78
360_A 364_A 1.125 0.78
538_L 546_T 1.122 0.77
866_T 870_H 1.121 0.77
866_T 877_K 1.12 0.77
551_Q 575_I 1.118 0.77
847_I 872_R 1.117 0.77
755_L 759_N 1.114 0.77
505_T 545_Q 1.11 0.76
41_A 131_H 1.11 0.76
47_T 223_Q 1.108 0.76
193_Q 197_C 1.107 0.76
735_N 750_V 1.107 0.76
535_S 542_G 1.103 0.76
703_E 707_A 1.103 0.76
29_A 35_A 1.102 0.76
322_P 325_G 1.102 0.76
870_H 873_N 1.102 0.76
880_V 889_H 1.1 0.75
660_W 663_T 1.096 0.75
848_Y 853_N 1.094 0.75
288_V 347_A 1.094 0.75
737_L 741_A 1.094 0.75
667_A 745_S 1.093 0.75
853_N 867_I 1.092 0.75
710_V 713_E 1.092 0.75
36_L 130_Y 1.092 0.75
21_R 25_K 1.091 0.74
732_L 758_A 1.09 0.74
698_Q 703_E 1.087 0.74
424_R 428_V 1.087 0.74
634_R 637_N 1.085 0.74
863_A 879_G 1.085 0.74
852_S 855_Q 1.083 0.74
288_V 350_S 1.082 0.74
590_E 615_L 1.078 0.73
218_W 221_A 1.077 0.73
137_V 218_W 1.077 0.73
41_A 323_L 1.076 0.73
535_S 547_A 1.075 0.73
195_F 222_L 1.075 0.73
276_I 347_A 1.074 0.73
468_A 497_V 1.073 0.73
428_V 458_V 1.073 0.73
139_H 215_V 1.073 0.73
843_V 860_L 1.072 0.73
626_D 663_T 1.068 0.72
160_R 323_L 1.067 0.72
631_Q 634_R 1.066 0.72
545_Q 583_W 1.066 0.72
854_E 873_N 1.066 0.72
45_K 160_R 1.064 0.72
129_D 321_H 1.064 0.72
839_R 871_I 1.063 0.72
629_R 633_N 1.063 0.72
361_I 373_L 1.061 0.72
494_L 498_L 1.061 0.72
271_L 328_L 1.06 0.71
842_Q 871_I 1.06 0.71
25_K 29_A 1.059 0.71
488_I 514_T 1.059 0.71
24_A 28_G 1.057 0.71
887_V 890_A 1.057 0.71
132_L 221_A 1.056 0.71
846_L 860_L 1.056 0.71
552_E 556_Q 1.055 0.71
260_L 327_F 1.054 0.71
711_L 737_L 1.051 0.70
735_N 754_A 1.05 0.70
132_L 137_V 1.05 0.70
837_T 870_H 1.049 0.70
191_A 208_S 1.048 0.70
847_I 868_K 1.048 0.70
73_R 77_Y 1.046 0.70
362_H 366_A 1.046 0.70
590_E 619_S 1.046 0.70
215_V 222_L 1.046 0.70
555_F 573_V 1.039 0.69
871_I 874_L 1.039 0.69
515_E 534_Q 1.038 0.69
878_L 883_R 1.038 0.69
853_N 873_N 1.037 0.69
192_K 205_A 1.035 0.69
756_K 760_R 1.035 0.69
854_E 865_T 1.035 0.69
868_K 886_A 1.031 0.68
43_Y 218_W 1.03 0.68
846_L 859_E 1.029 0.68
280_M 320_Y 1.029 0.68
265_L 269_H 1.026 0.68
866_T 878_L 1.026 0.68
847_I 880_V 1.024 0.68
544_L 761_T 1.023 0.68
866_T 883_R 1.023 0.68
16_T 39_S 1.023 0.68
595_S 599_V 1.023 0.68
847_I 873_N 1.021 0.67
724_M 727_L 1.021 0.67
358_S 383_S 1.02 0.67
160_R 321_H 1.019 0.67
184_L 218_W 1.018 0.67
765_S 769_I 1.017 0.67
188_H 212_C 1.016 0.67
24_A 27_S 1.016 0.67
194_F 222_L 1.015 0.67
216_S 322_P 1.015 0.67
186_F 194_F 1.014 0.67
699_I 711_L 1.013 0.66
575_I 614_M 1.012 0.66
865_T 876_Q 1.011 0.66
840_E 866_T 1.011 0.66
768_V 771_G 1.011 0.66
853_N 866_T 1.01 0.66
36_L 159_S 1.009 0.66
192_K 196_D 1.009 0.66
619_S 622_R 1.005 0.66
129_D 215_V 1.003 0.65
210_R 213_D 1.002 0.65
524_W 560_E 1.002 0.65
853_N 871_I 1.001 0.65
474_L 477_E 1.001 0.65
491_T 510_L 1 0.65
718_A 730_N 1 0.65
129_D 132_L 1 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1z6tA40.47841000.738Contact Map0.642
1hz4A10.4141000.784Contact Map0.797
2a5yB20.42621000.793Contact Map0.642
2qenA10.349699.90.821Contact Map0.664
2fnaA20.346399.90.832Contact Map0.667
3sf4A30.422999.90.839Contact Map0.772
1w5sA20.367499.90.841Contact Map0.558
3ro2A10.349699.90.847Contact Map0.744
4a1sA20.43499.90.852Contact Map0.79
1w3bA20.428499.80.859Contact Map0.83
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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