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OPENSEQ.org
CCA - Multifunctional CCA protein
UniProt: P06961 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10136
Length: 412 (405)
Sequences: 1931
Seq/Len: 4.77
CCA
Paralog alert: 0.33 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
135_V 202_A 3.434 1.00
209_E 287_R 3.303 1.00
378_V 388_I 3.213 1.00
191_Q 237_S 3.182 1.00
114_G 118_N 3.121 1.00
88_L 99_A 2.826 1.00
374_P 377_A 2.788 1.00
15_L 116_L 2.73 1.00
115_D 122_R 2.719 1.00
101_D 105_E 2.68 1.00
98_L 113_L 2.65 1.00
235_T 252_T 2.569 1.00
111_N 114_G 2.457 1.00
93_L 138_V 2.343 1.00
14_L 116_L 2.326 1.00
215_G 227_D 2.314 1.00
13_A 100_Q 2.307 1.00
3_I 24_W 2.25 1.00
143_A 187_T 2.244 1.00
95_I 121_L 2.239 1.00
113_L 117_Q 2.065 1.00
291_P 294_I 2.024 1.00
387_E 390_E 1.997 1.00
98_L 109_P 1.991 1.00
95_I 116_L 1.968 1.00
157_L 200_C 1.954 1.00
297_L 337_Q 1.946 1.00
391_E 395_R 1.94 1.00
320_V 400_V 1.899 1.00
170_E 205_V 1.858 1.00
133_L 173_T 1.842 1.00
195_Q 199_D 1.839 1.00
184_A 193_F 1.835 1.00
149_G 192_V 1.804 1.00
282_E 299_R 1.775 1.00
138_V 160_M 1.769 1.00
250_F 285_C 1.73 1.00
5_L 9_A 1.714 0.99
198_R 211_D 1.71 0.99
315_N 318_T 1.71 0.99
391_E 394_R 1.705 0.99
198_R 214_F 1.686 0.99
128_F 156_T 1.683 0.99
186_T 246_V 1.677 0.99
245_Q 337_Q 1.668 0.99
139_A 197_L 1.658 0.99
157_L 199_D 1.636 0.99
135_V 160_M 1.619 0.99
123_H 128_F 1.608 0.99
98_L 106_I 1.607 0.99
301_V 338_L 1.587 0.99
135_V 169_L 1.567 0.99
142_A 152_I 1.524 0.99
33_E 36_D 1.523 0.99
250_F 254_C 1.5 0.98
204_R 211_D 1.5 0.98
6_V 99_A 1.486 0.98
195_Q 230_I 1.485 0.98
122_R 153_A 1.474 0.98
116_L 119_R 1.471 0.98
336_E 364_R 1.455 0.98
152_I 156_T 1.445 0.98
386_V 390_E 1.443 0.98
182_E 246_V 1.433 0.98
285_C 295_R 1.432 0.98
114_G 117_Q 1.428 0.98
292_N 295_R 1.427 0.98
32_Q 36_D 1.408 0.97
108_D 112_G 1.407 0.97
139_A 202_A 1.405 0.97
83_T 86_D 1.399 0.97
383_F 391_E 1.395 0.97
2_K 28_G 1.394 0.97
178_W 182_E 1.386 0.97
142_A 196_V 1.385 0.97
178_W 290_V 1.38 0.97
84_L 99_A 1.362 0.96
84_L 88_L 1.361 0.96
375_T 388_I 1.357 0.96
87_D 140_R 1.354 0.96
286_Q 295_R 1.351 0.96
29_S 33_E 1.35 0.96
318_T 321_K 1.345 0.96
67_S 75_T 1.345 0.96
26_V 61_A 1.338 0.96
121_L 150_F 1.332 0.96
174_P 287_R 1.331 0.96
252_T 341_T 1.33 0.96
98_L 116_L 1.328 0.96
175_E 289_R 1.314 0.95
256_D 259_K 1.304 0.95
153_A 156_T 1.301 0.95
35_L 41_Q 1.297 0.95
304_F 325_S 1.297 0.95
139_A 160_M 1.291 0.95
385_G 389_R 1.287 0.95
376_K 379_V 1.279 0.94
189_N 237_S 1.267 0.94
386_V 389_R 1.264 0.94
301_V 341_T 1.262 0.94
121_L 138_V 1.258 0.94
152_I 196_V 1.25 0.94
384_K 388_I 1.247 0.93
7_G 11_R 1.246 0.93
69_S 72_T 1.246 0.93
124_V 130_E 1.246 0.93
72_T 76_C 1.242 0.93
97_A 124_V 1.242 0.93
255_H 259_K 1.239 0.93
123_H 156_T 1.238 0.93
214_F 229_G 1.236 0.93
132_P 168_E 1.232 0.93
378_V 392_L 1.232 0.93
85_E 109_P 1.229 0.93
231_H 255_H 1.228 0.93
371_Q 399_A 1.224 0.93
281_V 302_A 1.221 0.92
181_T 193_F 1.22 0.92
94_T 122_R 1.215 0.92
5_L 22_R 1.213 0.92
73_G 82_V 1.21 0.92
8_G 12_D 1.196 0.91
379_V 382_G 1.194 0.91
379_V 388_I 1.194 0.91
158_A 162_E 1.191 0.91
24_W 56_E 1.185 0.91
182_E 290_V 1.185 0.91
210_I 253_L 1.183 0.91
310_T 313_M 1.178 0.91
100_Q 104_G 1.176 0.90
46_F 59_A 1.171 0.90
273_H 345_D 1.168 0.90
304_F 326_I 1.168 0.90
305_H 345_D 1.164 0.90
259_K 273_H 1.159 0.90
138_V 152_I 1.156 0.89
197_L 203_L 1.154 0.89
68_G 74_F 1.154 0.89
372_S 399_A 1.149 0.89
324_D 393_T 1.147 0.89
144_R 187_T 1.143 0.89
389_R 393_T 1.141 0.89
123_H 159_L 1.139 0.89
343_E 347_R 1.133 0.88
383_F 387_E 1.13 0.88
327_D 330_R 1.125 0.88
273_H 277_G 1.122 0.88
89_K 110_Y 1.122 0.88
25_V 61_A 1.121 0.87
361_R 364_R 1.121 0.87
360_G 364_R 1.12 0.87
207_F 288_L 1.12 0.87
231_H 345_D 1.117 0.87
212_A 260_G 1.116 0.87
284_L 287_R 1.115 0.87
243_S 340_L 1.111 0.87
8_G 11_R 1.108 0.87
395_R 398_A 1.104 0.86
179_K 183_S 1.095 0.86
4_Y 61_A 1.094 0.86
30_T 33_E 1.094 0.86
8_G 21_D 1.092 0.86
42_V 46_F 1.087 0.85
169_L 205_V 1.086 0.85
231_H 256_D 1.078 0.85
231_H 305_H 1.077 0.84
181_T 207_F 1.075 0.84
295_R 299_R 1.068 0.84
151_R 196_V 1.067 0.84
43_G 57_E 1.066 0.84
129_G 163_M 1.061 0.83
239_A 243_S 1.059 0.83
285_C 298_A 1.058 0.83
69_S 133_L 1.055 0.83
308_I 338_L 1.05 0.82
248_V 341_T 1.049 0.82
282_E 286_Q 1.045 0.82
274_G 306_D 1.043 0.82
190_P 249_R 1.04 0.82
61_A 132_P 1.039 0.81
179_K 182_E 1.039 0.81
194_F 233_L 1.037 0.81
30_T 34_M 1.036 0.81
101_D 107_I 1.031 0.81
122_R 155_E 1.03 0.81
235_T 348_G 1.029 0.81
154_D 158_A 1.028 0.80
7_G 12_D 1.023 0.80
2_K 101_D 1.022 0.80
145_Y 150_F 1.017 0.80
256_D 345_D 1.017 0.80
317_K 401_A 1.014 0.79
99_A 110_Y 1.014 0.79
88_L 110_Y 1.013 0.79
99_A 109_P 1.012 0.79
218_A 223_H 1.011 0.79
320_V 397_I 1.01 0.79
48_V 59_A 1.01 0.79
133_L 169_L 1.008 0.79
262_T 276_A 1.007 0.79
135_V 163_M 1.007 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3h38A10.86651000.314Contact Map0.614
1miwA20.87381000.317Contact Map0.701
1vfgA20.88351000.319Contact Map0.625
1ou5A20.84951000.331Contact Map0.64
3aqlA20.86171000.415Contact Map0.65
4n6wA10.485497.90.92Contact Map0.549
3djbA20.46697.70.924Contact Map0.516
3dtoA40.46697.30.929Contact Map0.459
2qgsA20.46697.20.93Contact Map0.491
3b57A10.4636970.932Contact Map0.634
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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