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OPENSEQ.org
ERA - GTPase Era
UniProt: P06616 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10270
Length: 301 (294)
Sequences: 1559
Seq/Len: 5.30
ERA
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
219_E 234_L 4.277 1.00
11_I 58_A 3.941 1.00
201_K 264_D 3.345 1.00
56_Y 170_R 2.825 1.00
258_G 277_L 2.754 1.00
93_I 122_A 2.73 1.00
198_I 233_G 2.72 1.00
265_M 269_F 2.592 1.00
140_Q 144_S 2.493 1.00
178_H 182_E 2.466 1.00
194_A 221_F 2.43 1.00
8_C 176_A 2.396 1.00
213_S 242_Q 2.394 1.00
150_D 168_I 2.377 1.00
220_R 232_N 2.114 1.00
258_G 262_R 2.059 1.00
121_L 148_F 2.038 1.00
55_A 170_R 1.983 1.00
9_G 173_L 1.968 1.00
13_I 25_L 1.89 1.00
232_N 276_E 1.88 1.00
266_Q 272_P 1.88 1.00
79_N 82_A 1.871 1.00
91_L 169_V 1.851 1.00
243_K 247_I 1.837 1.00
122_A 165_I 1.809 1.00
19_V 123_V 1.796 1.00
202_L 214_V 1.795 1.00
27_K 159_G 1.789 1.00
203_M 212_Y 1.783 1.00
6_S 178_H 1.775 1.00
28_L 162_V 1.729 1.00
5_K 175_E 1.729 1.00
218_I 233_G 1.728 1.00
202_L 206_L 1.715 1.00
259_I 263_K 1.708 1.00
202_L 246_V 1.703 1.00
247_I 254_I 1.695 1.00
24_L 28_L 1.68 1.00
122_A 154_I 1.667 0.99
205_F 260_E 1.65 0.99
27_K 162_V 1.65 0.99
37_S 204_R 1.578 0.99
136_L 139_L 1.572 0.99
96_V 142_L 1.555 0.99
66_L 82_A 1.552 0.99
28_L 51_H 1.53 0.99
205_F 256_T 1.527 0.99
24_L 95_V 1.526 0.99
108_V 112_L 1.524 0.99
229_Y 271_A 1.522 0.99
143_A 151_I 1.477 0.99
31_Q 185_I 1.475 0.98
132_K 136_L 1.474 0.98
188_R 192_F 1.472 0.98
32_K 264_D 1.465 0.98
58_A 173_L 1.458 0.98
256_T 260_E 1.451 0.98
194_A 265_M 1.448 0.98
168_I 172_H 1.442 0.98
229_Y 269_F 1.436 0.98
150_D 172_H 1.418 0.98
106_E 145_Q 1.414 0.98
53_E 170_R 1.406 0.98
106_E 110_N 1.402 0.98
194_A 231_I 1.379 0.97
131_E 134_D 1.359 0.97
8_C 179_H 1.345 0.97
240_E 244_K 1.337 0.97
70_E 75_N 1.336 0.97
284_G 287_D 1.335 0.97
194_A 218_I 1.325 0.96
36_T 204_R 1.309 0.96
54_G 178_H 1.298 0.96
52_T 178_H 1.296 0.96
221_F 269_F 1.292 0.96
168_I 171_K 1.289 0.96
51_H 60_Y 1.287 0.96
93_I 169_V 1.282 0.96
246_V 279_V 1.279 0.95
124_N 156_A 1.265 0.95
29_L 51_H 1.264 0.95
206_L 257_I 1.257 0.95
163_D 167_A 1.256 0.95
152_V 168_I 1.251 0.95
244_K 254_I 1.245 0.94
67_H 82_A 1.243 0.94
150_D 164_T 1.24 0.94
98_G 123_V 1.235 0.94
224_N 230_D 1.233 0.94
238_E 242_Q 1.23 0.94
235_I 277_L 1.228 0.94
32_K 200_E 1.223 0.94
132_K 160_L 1.216 0.94
91_L 172_H 1.203 0.93
25_L 29_L 1.202 0.93
140_Q 143_A 1.186 0.92
201_K 260_E 1.184 0.92
120_I 172_H 1.177 0.92
139_L 153_P 1.177 0.92
292_L 295_L 1.176 0.92
236_L 295_L 1.175 0.92
181_P 184_Y 1.157 0.91
141_F 144_S 1.155 0.91
72_R 75_N 1.149 0.91
97_E 124_N 1.148 0.91
96_V 121_L 1.147 0.91
238_E 286_A 1.145 0.91
284_G 288_D 1.138 0.90
205_F 253_K 1.137 0.90
51_H 166_A 1.137 0.90
230_D 276_E 1.137 0.90
53_E 166_A 1.136 0.90
282_K 291_A 1.13 0.90
288_D 291_A 1.113 0.89
105_D 108_V 1.105 0.88
164_T 168_I 1.104 0.88
67_H 75_N 1.1 0.88
119_V 149_L 1.1 0.88
197_I 201_K 1.099 0.88
72_R 286_A 1.096 0.88
252_A 256_T 1.095 0.88
19_V 97_E 1.094 0.88
10_F 179_H 1.092 0.88
242_Q 245_M 1.091 0.88
119_V 146_M 1.087 0.87
53_E 56_Y 1.085 0.87
109_L 148_F 1.08 0.87
73_A 76_R 1.077 0.87
48_V 59_I 1.073 0.86
203_M 210_L 1.073 0.86
73_A 289_E 1.073 0.86
93_I 165_I 1.07 0.86
38_R 204_R 1.059 0.85
195_S 218_I 1.056 0.85
13_I 93_I 1.054 0.85
123_V 139_L 1.053 0.85
263_K 267_E 1.051 0.85
61_V 89_V 1.051 0.85
45_H 188_R 1.039 0.84
75_N 212_Y 1.038 0.84
164_T 167_A 1.035 0.84
25_L 49_G 1.034 0.83
132_K 135_L 1.028 0.83
206_L 253_K 1.022 0.82
232_N 274_H 1.021 0.82
247_I 279_V 1.017 0.82
13_I 49_G 1.017 0.82
161_N 164_T 1.015 0.82
223_S 271_A 1.012 0.82
25_L 60_Y 1.011 0.82
45_H 192_F 1.006 0.81
256_T 259_I 1.005 0.81
104_D 107_M 1.001 0.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ievA10.991000.285Contact Map0.754
1wf3A10.98011000.29Contact Map0.711
1egaA211000.3Contact Map0.691
2qptA10.92361000.553Contact Map0.215
3dm5A20.93021000.65Contact Map0.25
3zvrA10.98671000.653Contact Map0.211
1wxqA10.8871000.668Contact Map0.33
2x2eA20.82391000.675Contact Map0.269
1mkyA10.82721000.677Contact Map0.566
3kl4A10.89041000.679Contact Map0.228
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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