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OPENSEQ.org
GCP - Probable tRNA threonylcarbamoyladenosine biosynthesis protein Gcp
UniProt: P05852 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11171
Length: 337 (334)
Sequences: 2128
Seq/Len: 6.37
GCP
Paralog alert: 0.06 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
5_G 306_A 3.632 1.00
146_T 150_Q 3.484 1.00
207_L 257_Q 3.227 1.00
114_G 305_I 3.19 1.00
170_A 179_G 3.076 1.00
61_A 65_E 2.921 1.00
76_V 98_L 2.876 1.00
122_E 294_R 2.817 1.00
144_S 260_F 2.563 1.00
78_Y 106_A 2.505 1.00
73_I 104_V 2.504 1.00
176_D 182_L 2.446 1.00
184_S 273_R 2.444 1.00
59_I 94_V 2.407 1.00
190_G 234_D 2.324 1.00
280_A 284_K 2.297 1.00
77_A 309_G 2.287 1.00
241_D 274_T 2.279 1.00
9_S 79_T 2.262 1.00
2_R 68_L 2.237 1.00
15_I 58_L 2.201 1.00
146_T 152_E 2.17 1.00
262_R 289_E 2.164 1.00
197_F 221_T 2.065 1.00
255_L 263_L 2.055 1.00
199_R 245_D 2.022 1.00
5_G 309_G 2.016 1.00
74_D 104_V 2.013 1.00
70_A 102_W 1.999 1.00
191_T 194_R 1.978 1.00
183_L 236_A 1.976 1.00
188_A 273_R 1.931 1.00
78_Y 92_A 1.924 1.00
219_A 223_R 1.893 1.00
310_M 314_K 1.888 1.00
251_C 263_L 1.881 1.00
113_E 151_Y 1.853 1.00
15_I 59_I 1.851 1.00
239_F 243_V 1.848 1.00
237_R 241_D 1.844 1.00
14_G 302_G 1.838 1.00
182_L 185_K 1.822 1.00
70_A 73_I 1.818 1.00
26_A 62_A 1.814 1.00
3_V 75_A 1.811 1.00
114_G 308_A 1.81 1.00
198_P 217_F 1.807 1.00
169_T 239_F 1.792 1.00
195_F 221_T 1.786 1.00
135_V 275_L 1.782 1.00
60_Q 64_K 1.773 1.00
162_A 243_V 1.753 1.00
169_T 218_A 1.748 1.00
256_D 286_R 1.743 1.00
34_K 37_A 1.728 1.00
28_Q 61_A 1.725 1.00
199_R 242_A 1.71 1.00
144_S 152_E 1.694 1.00
186_M 232_R 1.664 1.00
50_D 53_R 1.662 1.00
28_Q 58_L 1.658 1.00
70_A 98_L 1.649 1.00
28_Q 65_E 1.647 1.00
112_M 134_L 1.627 1.00
95_G 106_A 1.62 1.00
78_Y 95_G 1.612 1.00
237_R 240_E 1.589 1.00
75_A 313_F 1.588 0.99
130_F 145_V 1.565 0.99
197_F 217_F 1.561 0.99
20_D 310_M 1.557 0.99
189_Q 233_A 1.534 0.99
107_I 318_T 1.509 0.99
27_N 62_A 1.507 0.99
69_T 72_D 1.502 0.99
158_I 208_D 1.481 0.99
62_A 66_S 1.471 0.99
197_F 235_I 1.446 0.99
147_G 150_Q 1.439 0.99
283_M 290_V 1.438 0.99
27_N 296_E 1.432 0.99
220_N 223_R 1.43 0.99
255_L 288_G 1.426 0.99
274_T 278_K 1.418 0.99
281_E 285_K 1.416 0.99
241_D 278_K 1.415 0.99
186_M 233_A 1.411 0.99
277_A 281_E 1.361 0.98
248_M 278_K 1.351 0.98
55_T 94_V 1.336 0.98
24_L 297_F 1.332 0.98
5_G 302_G 1.325 0.98
3_V 77_A 1.323 0.98
271_A 295_P 1.319 0.97
128_F 148_I 1.316 0.97
184_S 240_E 1.315 0.97
17_I 26_A 1.309 0.97
190_G 237_R 1.303 0.97
113_E 149_G 1.302 0.97
160_D 215_K 1.302 0.97
26_A 66_S 1.291 0.97
130_F 264_V 1.287 0.97
252_K 282_M 1.283 0.97
6_I 91_G 1.279 0.97
193_G 241_D 1.277 0.97
12_E 33_V 1.267 0.97
14_G 29_L 1.263 0.96
191_T 237_R 1.261 0.96
116_L 132_A 1.251 0.96
17_I 62_A 1.249 0.96
15_I 28_Q 1.249 0.96
17_I 68_L 1.235 0.96
186_M 189_Q 1.235 0.96
307_Y 311_V 1.232 0.96
108_P 319_A 1.22 0.95
181_P 185_K 1.22 0.95
240_E 274_T 1.219 0.95
63_L 70_A 1.217 0.95
154_L 258_T 1.212 0.95
274_T 277_A 1.208 0.95
169_T 172_L 1.203 0.95
142_L 209_F 1.194 0.95
244_V 278_K 1.193 0.95
30_Y 54_K 1.189 0.95
191_T 234_D 1.186 0.95
6_I 59_I 1.182 0.94
248_M 282_M 1.173 0.94
144_S 258_T 1.161 0.94
218_A 235_I 1.161 0.94
142_L 251_C 1.158 0.94
120_M 311_V 1.157 0.94
194_R 234_D 1.149 0.93
119_P 264_V 1.144 0.93
214_L 243_V 1.141 0.93
147_G 315_A 1.137 0.93
80_A 108_P 1.132 0.93
99_A 104_V 1.129 0.92
195_F 234_D 1.126 0.92
199_R 246_T 1.125 0.92
185_K 188_A 1.117 0.92
199_R 249_I 1.107 0.91
182_L 186_M 1.102 0.91
234_D 238_A 1.093 0.91
262_R 291_F 1.091 0.91
249_I 253_R 1.071 0.90
185_K 189_Q 1.069 0.89
218_A 239_F 1.067 0.89
222_I 235_I 1.056 0.89
81_G 110_H 1.049 0.88
194_R 238_A 1.049 0.88
17_I 73_I 1.047 0.88
2_R 17_I 1.041 0.88
99_A 106_A 1.038 0.87
234_D 237_R 1.034 0.87
172_L 219_A 1.033 0.87
97_S 101_A 1.028 0.87
98_L 104_V 1.019 0.86
246_T 250_K 1.016 0.86
76_V 104_V 1.016 0.86
45_E 49_R 1.015 0.86
184_S 188_A 1.015 0.86
2_R 74_D 1.013 0.86
28_Q 62_A 1.009 0.85
265_M 292_Y 1.007 0.85
190_G 238_A 1.005 0.85
48_S 86_G 1.004 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3en9A20.95251000.328Contact Map0.786
3zeuB211000.363Contact Map0.816
4k25A10.99111000.366Contact Map0.669
3venA10.93471000.435Contact Map0.372
3enoA20.95551000.445Contact Map0.743
2ivnA10.95551000.454Contact Map0.805
3vthA20.85761000.587Contact Map0.567
4g9iA60.89911000.591Contact Map0.556
3ttcA10.8221000.615Contact Map0.545
2ewsA20.75671000.668Contact Map0.508
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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