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OPENSEQ.org
DAPB - 4-hydroxy-tetrahydrodipicolinate reductase
UniProt: P04036 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10206
Length: 273 (266)
Sequences: 1676
Seq/Len: 6.30
DAPB
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
127_A 173_A 3.523 1.00
28_L 252_L 3.035 1.00
141_E 180_H 2.75 1.00
7_R 32_Q 2.515 1.00
30_G 252_L 2.476 1.00
138_K 142_K 2.472 1.00
139_L 143_A 2.462 1.00
107_D 110_G 2.382 1.00
90_A 113_A 2.364 1.00
34_G 73_F 2.313 1.00
136_M 233_I 2.308 1.00
116_D 119_A 2.308 1.00
221_T 234_T 2.155 1.00
175_G 208_F 2.119 1.00
21_L 79_F 1.934 1.00
67_D 94_Q 1.911 1.00
132_G 235_H 1.874 1.00
77_I 251_A 1.862 1.00
158_A 216_I 1.855 1.00
93_R 120_D 1.854 1.00
25_A 33_L 1.821 1.00
185_D 188_D 1.809 1.00
112_Q 115_R 1.796 1.00
20_Q 23_Q 1.781 1.00
98_G 122_A 1.771 1.00
8_V 31_V 1.769 1.00
156_I 211_V 1.751 1.00
86_L 110_G 1.738 1.00
10_I 21_L 1.731 1.00
221_T 232_E 1.722 1.00
13_A 36_A 1.701 1.00
9_A 73_F 1.668 1.00
140_L 174_M 1.656 1.00
173_A 177_A 1.641 1.00
124_V 267_V 1.628 1.00
12_G 15_G 1.62 1.00
232_E 236_K 1.6 1.00
156_I 223_M 1.589 0.99
89_L 93_R 1.58 0.99
115_R 119_A 1.57 0.99
81_R 164_V 1.569 0.99
259_S 262_F 1.551 0.99
47_S 51_E 1.544 0.99
65_S 68_A 1.531 0.99
85_T 106_F 1.529 0.99
19_R 23_Q 1.525 0.99
202_V 205_T 1.512 0.99
24_A 248_V 1.503 0.99
111_K 125_F 1.502 0.99
73_F 97_K 1.472 0.99
13_A 22_I 1.457 0.99
91_F 95_H 1.454 0.99
49_A 53_A 1.45 0.99
134_N 264_M 1.443 0.99
237_A 243_F 1.424 0.99
25_A 31_V 1.417 0.99
10_I 25_A 1.416 0.99
136_M 231_L 1.408 0.98
230_R 238_S 1.388 0.98
90_A 94_Q 1.388 0.98
153_I 178_I 1.384 0.98
86_L 106_F 1.372 0.98
142_K 145_K 1.37 0.98
108_E 187_K 1.362 0.98
193_S 196_G 1.338 0.98
219_E 236_K 1.324 0.97
75_V 100_V 1.323 0.97
99_M 123_I 1.312 0.97
11_A 37_L 1.303 0.97
124_V 254_L 1.289 0.97
76_F 92_C 1.282 0.97
108_E 112_Q 1.28 0.97
110_G 113_A 1.275 0.97
137_L 177_A 1.269 0.97
6_I 75_V 1.269 0.97
115_R 118_A 1.266 0.96
67_D 95_H 1.26 0.96
211_V 223_M 1.245 0.96
112_Q 116_D 1.235 0.96
48_D 59_G 1.227 0.96
14_G 38_E 1.224 0.95
11_A 88_H 1.209 0.95
213_A 225_A 1.204 0.95
23_Q 27_A 1.2 0.95
31_V 252_L 1.195 0.95
215_D 238_S 1.193 0.95
184_K 204_G 1.19 0.95
51_E 57_K 1.19 0.95
96_G 120_D 1.179 0.94
86_L 89_L 1.175 0.94
184_K 189_C 1.174 0.94
16_R 162_H 1.174 0.94
141_E 145_K 1.174 0.94
135_V 146_V 1.157 0.93
48_D 54_G 1.152 0.93
36_A 49_A 1.152 0.93
215_D 228_G 1.148 0.93
141_E 181_A 1.147 0.93
98_G 255_S 1.145 0.93
122_A 262_F 1.144 0.93
237_A 242_T 1.138 0.93
11_A 76_F 1.136 0.93
87_N 90_A 1.133 0.92
45_L 64_S 1.129 0.92
220_H 235_H 1.126 0.92
124_V 250_S 1.121 0.92
216_I 219_E 1.118 0.92
50_G 54_G 1.114 0.92
155_I 175_G 1.096 0.91
129_F 248_V 1.094 0.91
192_Y 195_E 1.092 0.90
137_L 173_A 1.09 0.90
134_N 137_L 1.082 0.90
9_A 35_A 1.076 0.90
28_L 31_V 1.074 0.90
70_K 91_F 1.064 0.89
140_L 178_I 1.062 0.89
31_V 248_V 1.061 0.89
64_S 68_A 1.056 0.88
158_A 211_V 1.055 0.88
193_S 210_T 1.055 0.88
151_T 226_D 1.054 0.88
80_T 102_G 1.05 0.88
248_V 252_L 1.038 0.87
111_K 115_R 1.031 0.87
7_R 74_D 1.029 0.87
253_W 257_K 1.029 0.87
162_H 227_I 1.028 0.87
136_M 174_M 1.027 0.87
66_L 91_F 1.025 0.86
17_M 244_A 1.023 0.86
132_G 220_H 1.023 0.86
193_S 205_T 1.022 0.86
21_L 77_I 1.021 0.86
67_D 91_F 1.016 0.86
140_L 233_I 1.011 0.85
109_A 112_Q 1.009 0.85
138_K 141_E 1.005 0.85
24_A 241_M 1.002 0.85
9_A 34_G 1.001 0.85
77_I 248_V 1 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vm6A40.80951000.188Contact Map0.802
1dihA111000.212Contact Map0.617
1p9lA20.87551000.232Contact Map0.746
3ijpA20.99631000.239Contact Map0.722
4f3yA20.98171000.363Contact Map0.724
3qy9A40.89011000.41Contact Map0.755
1j5pA10.83521000.618Contact Map0.399
1f06A20.90481000.64Contact Map0.392
3bioA20.926799.70.8Contact Map0.611
2nu8A20.864599.70.807Contact Map0.543
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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