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DNAA - Chromosomal replication initiator protein DnaA
UniProt: P03004 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10235
Length: 467 (462)
Sequences: 1429
Seq/Len: 3.09
DNAA
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
376_I 380_Q 3.049 1.00
188_G 191_A 2.834 1.00
227_R 253_T 2.73 1.00
153_A 290_L 2.609 1.00
185_V 265_I 2.585 1.00
31_A 38_L 2.541 1.00
411_M 437_V 2.484 1.00
307_M 319_G 2.457 1.00
376_I 414_A 2.412 1.00
321_V 359_V 2.283 1.00
387_Y 457_D 2.28 1.00
426_G 431_G 2.166 1.00
189_I 231_A 2.158 1.00
258_L 288_W 2.143 1.00
448_R 458_F 2.12 1.00
435_T 438_L 2.06 1.00
299_L 303_V 2.027 1.00
341_N 348_N 2.017 1.00
384_A 391_V 1.984 1.00
48_L 52_R 1.975 1.00
204_E 253_T 1.876 0.99
204_E 227_R 1.871 0.99
209_D 226_Y 1.871 0.99
455_K 459_S 1.866 0.99
210_M 245_R 1.822 0.99
444_I 454_I 1.819 0.99
143_E 151_R 1.816 0.99
16_E 58_N 1.799 0.99
429_F 440_A 1.792 0.99
157_V 168_L 1.776 0.99
461_L 465_L 1.761 0.99
193_K 196_A 1.712 0.99
50_W 54_K 1.693 0.98
38_L 63_L 1.672 0.98
227_R 249_E 1.67 0.98
273_K 287_G 1.666 0.98
204_E 239_F 1.661 0.98
250_F 266_L 1.659 0.98
199_V 229_V 1.656 0.98
145_K 148_Q 1.655 0.98
412_A 458_F 1.643 0.98
410_A 429_F 1.639 0.98
153_A 168_L 1.637 0.98
426_G 430_G 1.613 0.98
408_Q 411_M 1.609 0.98
325_I 343_V 1.597 0.97
386_Y 457_D 1.571 0.97
416_E 445_E 1.569 0.97
380_Q 395_L 1.561 0.97
356_I 360_R 1.549 0.97
282_L 286_F 1.547 0.97
19_A 23_S 1.546 0.97
227_R 252_H 1.54 0.97
151_R 155_R 1.534 0.97
448_R 455_K 1.531 0.96
32_E 41_Y 1.516 0.96
380_Q 429_F 1.515 0.96
209_D 225_Y 1.505 0.96
306_L 340_L 1.499 0.96
376_I 428_A 1.475 0.95
306_L 336_L 1.468 0.95
207_V 246_S 1.465 0.95
13_L 26_I 1.459 0.95
275_I 278_V 1.445 0.95
309_K 337_E 1.441 0.95
284_S 332_N 1.44 0.95
210_M 214_L 1.431 0.94
390_K 393_D 1.428 0.94
58_N 62_L 1.428 0.94
408_Q 439_H 1.42 0.94
169_F 291_T 1.411 0.94
214_L 219_I 1.41 0.94
387_Y 409_M 1.399 0.93
318_P 321_V 1.394 0.93
310_A 322_A 1.394 0.93
446_Q 450_E 1.389 0.93
448_R 454_I 1.388 0.93
324_F 367_L 1.387 0.93
29_L 40_L 1.381 0.93
437_V 440_A 1.38 0.93
9_C 63_L 1.377 0.93
152_A 304_A 1.375 0.93
249_E 253_T 1.366 0.92
210_M 222_F 1.355 0.92
251_F 254_F 1.345 0.91
391_V 395_L 1.338 0.91
381_K 385_E 1.337 0.91
416_E 462_I 1.329 0.91
26_I 29_L 1.324 0.91
223_K 249_E 1.319 0.90
142_V 308_K 1.313 0.90
106_P 111_P 1.311 0.90
303_V 322_A 1.301 0.90
255_N 259_E 1.299 0.90
321_V 356_I 1.295 0.89
201_M 226_Y 1.286 0.89
441_C 445_E 1.279 0.89
380_Q 394_L 1.276 0.88
340_L 363_L 1.271 0.88
158_A 188_G 1.269 0.88
443_K 446_Q 1.266 0.88
23_S 27_R 1.265 0.88
218_A 221_E 1.263 0.88
335_E 363_L 1.25 0.87
10_L 26_I 1.248 0.87
87_P 92_T 1.247 0.87
252_H 255_N 1.239 0.86
176_L 332_N 1.236 0.86
415_K 442_R 1.236 0.86
251_F 281_R 1.234 0.86
188_G 192_R 1.234 0.86
393_D 398_R 1.233 0.86
423_P 435_T 1.232 0.86
56_L 74_L 1.225 0.85
12_R 65_S 1.223 0.85
376_I 420_H 1.223 0.85
303_V 323_F 1.212 0.85
347_A 358_F 1.212 0.85
37_T 75_R 1.21 0.85
156_Q 304_A 1.21 0.85
300_E 304_A 1.208 0.84
426_G 432_R 1.207 0.84
342_R 347_A 1.202 0.84
424_E 427_D 1.2 0.84
154_A 185_V 1.199 0.84
44_N 47_V 1.198 0.84
174_T 284_S 1.191 0.83
372_K 406_P 1.179 0.82
14_Q 27_R 1.176 0.82
87_P 98_P 1.173 0.82
386_Y 460_N 1.17 0.82
454_I 457_D 1.167 0.81
214_L 223_K 1.166 0.81
233_L 267_T 1.165 0.81
385_E 464_T 1.164 0.81
149_L 345_A 1.162 0.81
227_R 239_F 1.161 0.81
176_L 301_T 1.161 0.81
254_F 264_I 1.159 0.81
208_Q 253_T 1.155 0.81
21_E 55_Y 1.155 0.81
460_N 464_T 1.154 0.80
267_T 277_G 1.152 0.80
157_V 263_Q 1.152 0.80
46_F 55_Y 1.148 0.80
245_R 253_T 1.144 0.80
413_L 462_I 1.143 0.80
204_E 243_K 1.139 0.79
159_D 192_R 1.135 0.79
25_W 50_W 1.135 0.79
237_I 266_L 1.126 0.78
380_Q 391_V 1.125 0.78
187_N 291_T 1.124 0.78
252_H 279_E 1.111 0.77
324_F 404_A 1.111 0.77
102_A 111_P 1.109 0.77
132_V 186_G 1.109 0.77
46_F 50_W 1.104 0.76
302_R 440_A 1.103 0.76
141_F 181_L 1.103 0.76
62_L 66_F 1.099 0.76
397_K 432_R 1.097 0.76
226_Y 254_F 1.097 0.76
432_R 439_H 1.092 0.75
93_S 118_D 1.092 0.75
207_V 211_V 1.091 0.75
317_L 322_A 1.084 0.74
302_R 411_M 1.082 0.74
138_F 184_A 1.08 0.74
51_V 76_F 1.076 0.74
270_R 280_D 1.074 0.73
152_A 213_A 1.073 0.73
33_L 39_A 1.071 0.73
414_A 429_F 1.069 0.73
240_F 292_V 1.068 0.73
332_N 335_E 1.065 0.72
161_P 263_Q 1.064 0.72
40_L 76_F 1.061 0.72
26_I 51_V 1.06 0.72
208_Q 415_K 1.059 0.72
22_F 26_I 1.058 0.72
150_A 181_L 1.055 0.71
132_V 182_L 1.049 0.71
324_F 356_I 1.048 0.71
415_K 422_L 1.047 0.71
199_V 225_Y 1.042 0.70
278_V 282_L 1.042 0.70
290_L 345_A 1.038 0.70
156_Q 293_A 1.037 0.70
189_I 192_R 1.036 0.69
352_R 361_E 1.035 0.69
11_A 14_Q 1.034 0.69
59_I 354_I 1.033 0.69
238_Q 250_F 1.032 0.69
29_L 42_A 1.028 0.69
342_R 365_D 1.027 0.69
277_G 333_V 1.026 0.68
35_D 314_D 1.021 0.68
203_S 301_T 1.02 0.68
254_F 263_Q 1.019 0.68
400_S 404_A 1.018 0.68
172_G 282_L 1.017 0.67
64_T 70_D 1.016 0.67
173_G 176_L 1.014 0.67
144_G 176_L 1.013 0.67
221_E 224_R 1.011 0.67
358_F 362_A 1.01 0.67
26_I 348_N 1.009 0.67
405_R 444_I 1.007 0.66
230_D 262_Q 1.004 0.66
404_A 439_H 1.004 0.66
55_Y 149_L 1.003 0.66
189_I 196_A 1.003 0.66
50_W 55_Y 1.001 0.66
75_R 78_V 1.001 0.66
149_L 211_V 1 0.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2z4sA10.92081000.396Contact Map0.59
1l8qA10.68521000.579Contact Map0.575
3nbxX10.71091000.648Contact Map0.232
3bosA20.51611000.771Contact Map0.548
1j1vA10.20131000.783Contact Map0.687
3pvvA20.20771000.789Contact Map0.802
2qgzA10.59311000.801Contact Map0.492
2r44A10.56961000.824Contact Map0.272
3u61B40.663899.90.838Contact Map0.375
3hwsA60.526899.90.844Contact Map0.412
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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