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OPENSEQ.org
SYGA - Glycine--tRNA ligase alpha subunit
UniProt: P00960 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10409
Length: 303 (294)
Sequences: 612
Seq/Len: 2.08
SYGA
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
19_Y 100_G 4.712 1.00
17_Q 83_F 3.775 1.00
200_H 204_V 3.448 1.00
55_A 87_I 3.215 1.00
100_G 103_K 3.198 1.00
108_D 111_I 3.07 1.00
221_T 225_Q 2.771 1.00
41_H 60_Q 2.765 1.00
40_S 123_N 2.694 1.00
123_N 126_L 2.626 1.00
18_D 22_R 2.578 1.00
199_F 202_N 2.532 1.00
86_V 160_T 2.471 1.00
78_Q 210_N 2.436 1.00
201_Q 205_E 2.399 1.00
52_E 291_R 2.334 1.00
26_T 193_T 2.148 1.00
12_L 171_A 2.138 0.99
93_N 97_L 2.123 0.99
94_I 161_G 2.012 0.99
48_E 156_C 2.012 0.99
227_E 275_R 1.998 0.99
222_C 226_Y 1.983 0.99
202_N 206_Q 1.979 0.99
215_D 232_Q 1.974 0.99
80_Y 210_N 1.966 0.99
213_Y 236_L 1.96 0.99
213_Y 233_L 1.959 0.99
15_T 104_E 1.944 0.99
103_K 110_T 1.901 0.99
77_L 180_V 1.879 0.98
49_L 288_Y 1.878 0.98
103_K 109_P 1.875 0.98
81_Y 199_F 1.866 0.98
78_Q 81_Y 1.855 0.98
35_V 60_Q 1.848 0.98
11_G 15_T 1.837 0.98
93_N 96_E 1.818 0.98
45_C 284_A 1.811 0.98
34_E 250_K 1.8 0.98
23_Q 93_N 1.793 0.98
40_S 252_A 1.686 0.96
230_A 248_I 1.686 0.96
15_T 18_D 1.673 0.96
170_L 174_I 1.673 0.96
22_R 104_E 1.63 0.95
40_S 249_L 1.613 0.95
226_Y 247_R 1.608 0.95
81_Y 210_N 1.596 0.94
142_V 170_L 1.572 0.94
62_S 180_V 1.569 0.94
109_P 114_I 1.563 0.94
14_L 17_Q 1.541 0.93
112_H 138_N 1.537 0.93
285_E 289_A 1.513 0.92
184_V 188_G 1.501 0.92
8_T 187_D 1.479 0.91
56_A 160_T 1.477 0.91
152_G 284_A 1.452 0.90
59_V 62_S 1.451 0.90
291_R 297_P 1.441 0.89
79_H 210_N 1.439 0.89
52_E 297_P 1.433 0.89
8_T 11_G 1.431 0.89
125_T 273_I 1.425 0.89
270_Q 274_L 1.418 0.88
252_A 276_I 1.411 0.88
294_L 297_P 1.408 0.88
216_V 220_F 1.39 0.87
216_V 263_A 1.385 0.87
222_C 225_Q 1.372 0.86
218_F 225_Q 1.343 0.84
229_E 232_Q 1.338 0.84
42_P 246_E 1.33 0.84
221_T 224_E 1.326 0.83
181_Y 196_G 1.324 0.83
202_N 242_L 1.322 0.83
218_F 222_C 1.306 0.82
232_Q 236_L 1.305 0.82
56_A 86_V 1.287 0.81
292_E 299_C 1.284 0.81
160_T 284_A 1.283 0.80
123_N 276_I 1.279 0.80
208_T 213_Y 1.259 0.79
12_L 105_L 1.255 0.78
143_T 163_I 1.223 0.76
52_E 296_F 1.221 0.76
156_C 159_V 1.22 0.76
87_I 94_I 1.218 0.75
87_I 161_G 1.201 0.74
9_F 167_L 1.19 0.73
40_S 276_I 1.184 0.73
95_Q 116_F 1.183 0.72
213_Y 232_Q 1.168 0.71
206_Q 246_E 1.167 0.71
208_T 212_E 1.159 0.70
135_V 152_G 1.147 0.69
286_A 289_A 1.143 0.69
94_I 163_I 1.143 0.69
18_D 21_A 1.137 0.68
247_R 251_A 1.129 0.67
177_V 184_V 1.129 0.67
291_R 296_F 1.124 0.67
204_V 208_T 1.11 0.65
7_R 15_T 1.11 0.65
53_P 299_C 1.108 0.65
226_Y 254_S 1.102 0.65
219_L 257_L 1.102 0.65
32_D 63_R 1.101 0.64
68_G 211_F 1.09 0.63
10_Q 34_E 1.076 0.62
215_D 228_K 1.075 0.62
154_L 288_Y 1.075 0.62
123_N 252_A 1.072 0.61
220_F 264_I 1.069 0.61
49_L 234_L 1.067 0.61
28_V 43_M 1.063 0.60
12_L 167_L 1.062 0.60
66_T 80_Y 1.055 0.60
281_K 285_E 1.047 0.59
205_E 242_L 1.042 0.58
120_N 284_A 1.035 0.57
98_Y 102_L 1.035 0.57
96_E 100_G 1.034 0.57
215_D 293_A 1.033 0.57
218_F 221_T 1.032 0.57
155_E 274_L 1.031 0.57
13_I 167_L 1.027 0.56
215_D 229_E 1.026 0.56
240_L 243_P 1.024 0.56
24_G 186_S 1.02 0.56
271_R 274_L 1.02 0.56
53_P 292_E 1.013 0.55
289_A 293_A 1.007 0.54
217_D 221_T 1.005 0.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1j5wA20.96371000.023Contact Map0.729
3rf1A20.96371000.025Contact Map0.665
2zzeA20.93731000.711Contact Map0.336
2ztgA10.95051000.72Contact Map0.412
1yfsA20.818597.10.957Contact Map0.448
3hy0A20.828496.90.958Contact Map0.352
3qtcA10.597495.80.962Contact Map0.578
3dsqA20.590895.30.964Contact Map0.515
3a5yA40.610663.10.977Contact Map0.439
3l4gA80.656849.40.979Contact Map0.29
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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