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OPENSEQ.org
PHR - Deoxyribodipyrimidine photo-lyase
UniProt: P00914 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10736
Length: 472 (463)
Sequences: 2066
Seq/Len: 4.46
PHR
Paralog alert: 0.18 [within 20: 0.03] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
241_S 246_G 3.825 1.00
326_I 347_I 3.735 1.00
335_N 366_Y 3.573 1.00
355_D 457_A 3.446 1.00
310_N 313_H 3.201 1.00
332_R 422_E 3.114 1.00
314_L 362_E 2.995 1.00
355_D 454_H 2.99 1.00
330_A 344_L 2.964 1.00
314_L 318_Q 2.782 1.00
58_Q 246_G 2.659 1.00
297_P 303_D 2.646 1.00
335_N 370_Q 2.547 1.00
100_L 121_L 2.523 1.00
63_Q 67_A 2.504 1.00
332_R 420_L 2.455 1.00
102_Y 126_C 2.435 1.00
417_R 428_G 2.433 1.00
316_A 451_I 2.424 1.00
315_Q 319_E 2.403 1.00
101_F 129_F 2.392 1.00
406_G 416_I 2.382 1.00
454_H 457_A 2.329 1.00
324_Y 351_F 2.317 1.00
344_L 415_F 2.314 1.00
61_G 206_K 2.276 1.00
308_Q 313_H 2.238 1.00
282_Y 382_G 2.211 1.00
337_T 419_W 2.121 1.00
102_Y 128_G 2.12 1.00
324_Y 454_H 2.098 1.00
366_Y 370_Q 2.08 1.00
82_V 87_I 2.076 1.00
333_Q 415_F 2.055 1.00
63_Q 72_P 2.031 1.00
417_R 431_V 2.025 1.00
458_R 462_L 2.024 1.00
406_G 432_H 2.002 1.00
404_T 408_K 1.97 1.00
34_L 91_V 1.946 1.00
6_V 17_N 1.936 1.00
282_Y 381_G 1.919 1.00
17_N 103_N 1.915 1.00
336_S 419_W 1.874 1.00
205_E 208_A 1.868 1.00
8_F 66_L 1.854 1.00
426_V 437_W 1.837 1.00
6_V 19_A 1.818 1.00
34_L 88_V 1.81 1.00
207_A 210_A 1.8 1.00
313_H 451_I 1.798 1.00
58_Q 204_E 1.793 1.00
8_F 33_A 1.781 1.00
430_V 438_A 1.774 1.00
407_E 433_E 1.774 1.00
15_H 251_Q 1.761 1.00
308_Q 464_A 1.756 1.00
315_Q 318_Q 1.752 1.00
333_Q 337_T 1.748 1.00
368_M 374_G 1.747 1.00
316_A 321_K 1.726 0.99
323_G 328_D 1.724 0.99
5_L 97_V 1.722 0.99
433_E 436_K 1.715 0.99
427_P 430_V 1.703 0.99
204_E 208_A 1.684 0.99
412_E 428_G 1.668 0.99
92_C 97_V 1.648 0.99
413_G 417_R 1.641 0.99
230_P 344_L 1.637 0.99
333_Q 339_W 1.634 0.99
216_C 220_A 1.629 0.99
352_L 358_I 1.62 0.99
318_Q 369_S 1.595 0.99
212_L 252_C 1.591 0.99
8_F 62_L 1.584 0.99
18_L 131_D 1.581 0.99
205_E 251_Q 1.58 0.99
100_L 126_C 1.576 0.99
349_A 386_A 1.573 0.99
76_R 94_E 1.563 0.99
154_F 284_H 1.557 0.99
33_A 71_I 1.549 0.99
317_W 331_M 1.544 0.98
91_V 95_N 1.531 0.98
352_L 363_G 1.529 0.98
107_E 376_L 1.528 0.98
155_K 277_I 1.52 0.98
55_I 244_T 1.519 0.98
111_R 287_T 1.518 0.98
10_Q 105_Q 1.511 0.98
292_L 380_N 1.499 0.98
99_H 127_E 1.49 0.98
76_R 87_I 1.484 0.98
242_L 252_C 1.477 0.98
151_F 274_N 1.471 0.98
53_E 57_A 1.462 0.98
399_I 462_L 1.455 0.98
118_E 128_G 1.445 0.97
135_L 158_W 1.439 0.97
367_F 371_L 1.436 0.97
238_L 252_C 1.433 0.97
363_G 383_W 1.431 0.97
65_A 206_K 1.429 0.97
65_A 205_E 1.427 0.97
57_A 203_V 1.424 0.97
208_A 247_L 1.423 0.97
99_H 125_V 1.414 0.97
357_L 460_Q 1.398 0.97
54_L 241_S 1.395 0.97
9_R 114_D 1.391 0.97
61_G 65_A 1.39 0.97
453_E 456_E 1.388 0.96
459_V 463_A 1.379 0.96
330_A 415_F 1.378 0.96
34_L 76_R 1.362 0.96
36_I 88_V 1.348 0.96
83_A 86_E 1.339 0.95
212_L 255_R 1.339 0.95
87_I 90_Q 1.339 0.95
222_E 226_Q 1.338 0.95
364_E 380_N 1.335 0.95
39_P 77_E 1.329 0.95
15_H 205_E 1.325 0.95
311_P 362_E 1.321 0.95
90_Q 94_E 1.321 0.95
326_I 406_G 1.317 0.95
67_A 72_P 1.308 0.95
275_E 378_A 1.306 0.95
357_L 461_T 1.298 0.94
84_S 89_K 1.29 0.94
286_I 377_A 1.288 0.94
238_L 272_W 1.272 0.93
403_T 406_G 1.267 0.93
382_G 386_A 1.266 0.93
460_Q 464_A 1.258 0.93
362_E 365_R 1.255 0.93
236_S 272_W 1.246 0.93
35_Y 55_I 1.245 0.93
158_W 277_I 1.244 0.92
132_S 283_R 1.241 0.92
324_Y 355_D 1.219 0.91
312_A 316_A 1.218 0.91
343_R 405_Q 1.218 0.91
111_R 115_V 1.217 0.91
455_K 459_V 1.209 0.91
15_H 209_I 1.208 0.91
32_L 74_L 1.206 0.91
251_Q 255_R 1.204 0.91
309_S 362_E 1.199 0.91
14_L 69_K 1.195 0.90
134_I 158_W 1.195 0.90
351_F 451_I 1.192 0.90
215_F 236_S 1.187 0.90
54_L 204_E 1.185 0.90
416_I 431_V 1.181 0.90
7_W 117_V 1.18 0.90
443_V 446_D 1.176 0.89
66_L 71_I 1.175 0.89
105_Q 113_R 1.175 0.89
209_I 251_Q 1.17 0.89
61_G 203_V 1.166 0.89
85_V 89_K 1.162 0.89
32_L 95_N 1.16 0.89
403_T 435_W 1.149 0.88
85_V 116_E 1.145 0.88
155_K 274_N 1.145 0.88
230_P 326_I 1.143 0.88
247_L 252_C 1.143 0.88
107_E 110_E 1.134 0.87
21_A 25_R 1.123 0.86
4_H 101_F 1.122 0.86
227_R 275_E 1.12 0.86
376_L 380_N 1.117 0.86
6_V 101_F 1.113 0.86
413_G 434_P 1.112 0.86
54_L 246_G 1.111 0.85
235_T 339_W 1.109 0.85
271_V 274_N 1.107 0.85
92_C 95_N 1.104 0.85
54_L 240_A 1.103 0.85
236_S 273_L 1.103 0.85
277_I 280_E 1.099 0.85
106_Y 133_V 1.099 0.85
50_R 370_Q 1.097 0.85
22_A 25_R 1.095 0.84
393_A 397_F 1.095 0.84
5_L 34_L 1.09 0.84
74_L 91_V 1.087 0.84
325_P 416_I 1.085 0.84
255_R 258_A 1.083 0.83
86_E 90_Q 1.08 0.83
356_L 452_V 1.074 0.83
104_Y 136_P 1.072 0.83
314_L 358_I 1.072 0.83
456_E 459_V 1.071 0.83
318_Q 366_Y 1.059 0.82
36_I 84_S 1.056 0.81
296_R 303_D 1.052 0.81
204_E 246_G 1.048 0.81
275_E 346_M 1.043 0.80
426_V 434_P 1.042 0.80
400_F 405_Q 1.037 0.80
427_P 434_P 1.034 0.79
456_E 460_Q 1.033 0.79
92_C 124_V 1.03 0.79
60_N 64_I 1.021 0.78
324_Y 457_A 1.02 0.78
253_L 273_L 1.006 0.77
340_M 367_F 1.005 0.77
367_F 383_W 1.004 0.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1dnpA20.99361000.056Contact Map0.749
1u3dA10.98521000.074Contact Map0.764
1owlA10.96821000.075Contact Map0.785
1np7A20.97461000.077Contact Map0.815
3fy4A30.98091000.084Contact Map0.771
4k0rA10.98091000.086Contact Map0.707
3tvsA10.98311000.091Contact Map0.598
4mlpC40.98091000.1Contact Map0.74
4i6gA20.98091000.1Contact Map0.74
2wq7A10.98091000.113Contact Map0.773
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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