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OPENSEQ.org

THIS - Sulfur carrier protein ThiS
UniProt: O32583 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14363
Length: 66 (66)
Sequences: 1194
Seq/Len: 18.09

THIS
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
37_N 55_D 4.316 1.00
36_I 49_H 2.694 1.00
36_I 57_I 2.187 1.00
10_M 25_L 2.077 1.00
18_V 34_L 2.005 1.00
45_Q 48_Q 2.004 1.00
35_A 64_A 1.984 1.00
2_Q 11_Q 1.85 1.00
19_H 47_A 1.714 1.00
31_G 46_W 1.494 1.00
40_I 46_W 1.477 1.00
60_F 64_A 1.432 1.00
7_D 58_L 1.38 0.99
18_V 41_V 1.337 0.99
20_E 23_E 1.314 0.99
2_Q 53_D 1.303 0.99
13_A 24_Q 1.3 0.99
21_L 51_V 1.295 0.99
35_A 46_W 1.283 0.99
31_G 35_A 1.278 0.99
4_L 56_Q 1.251 0.99
2_Q 9_A 1.25 0.99
21_L 25_L 1.247 0.99
43_R 46_W 1.209 0.98
35_A 40_I 1.201 0.98
58_L 63_I 1.191 0.98
36_I 41_V 1.167 0.97
16_Q 20_E 1.15 0.97
61_Q 64_A 1.132 0.97
60_F 63_I 1.126 0.97
35_A 62_V 1.122 0.97
1_M 53_D 1.112 0.96
35_A 58_L 1.107 0.96
34_L 46_W 1.089 0.96
1_M 11_Q 1.062 0.95
36_I 52_Q 1.042 0.94
5_F 21_L 1.024 0.93
4_L 9_A 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2kl0A10.984899.80.075Contact Map0.565
2k5pA1199.80.081Contact Map0.559
1tygB2199.70.156Contact Map0.714
1f0zA1199.60.191Contact Map0.527
2cu3A20.969799.60.22Contact Map0.569
4hrsA10.924299.30.346Contact Map0.273
1ryjA10.939499.20.353Contact Map0.434
2l32A10.924299.20.371Contact Map0.288
1rwsA10.9394990.404Contact Map0.08
3rpfC20.939498.90.435Contact Map0.491

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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