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1XQR_A HspBP1 1S3X_A Hsp70 ATPase domain ATP
Genes: A B A+B
Length: 296 382 656
Sequences: 9573 12890 457
Seq/Len: 32.34 33.74 0.7
MirrorTree (Pazo et al. 2001) 0.09
Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.

[Show Jackhmmer results] - Maybe useful in deciding what regions to trim.
Δgene Ratio of paralogs Joined
A B Seq/Len
1 0.10 0.05 0.09
2 0.11 0.06 0.13
5 0.14 0.08 0.25
10 0.16 0.09 0.40
20 0.17 0.10 0.67
100 0.22 0.15 1.97
∞ 0.27 0.21 3.33
Paired alignment generation
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Sequence A E-value:
Iterations:
Sequence B E-value:
Iterations:
Δgene MSA
Figure 1: The effect of Δgene on ratio of paralogs in the genome for each gene, and the number of sequences in the resulting joined alignment. Figure 2: Distribution of Δgene across all genomes. Figure 3: Current parameters. You can use the form to adjust the parameters and resubmit the job!
GREMLIN results (Scaled_score > 1):
Figure 4: The darker and larger the blue dots, the higher strength in coevolution. 		Inter Residue pairs sorted by strength in coevolution signal:
i j Scaled Score Prob I_Prob
203_G 334_L 1.14 0.37 0.00
195_L 334_L 1.08 0.33 0.00
233_L 95_I 1.05 0.30 0.00
53_D 282_L 1.03 0.29 0.00
93_A 170_L 1.03 0.29 0.00
262_C 221_A 1.00 0.27 0.00
197_G 350_L 0.99 0.26 0.00
226_H 113_A 0.99 0.26 0.00
211_V 19_G 0.98 0.26 0.00
191_L 15_Y 0.95 0.24 0.00
109_C 239_N 0.95 0.23 0.00
45_A 346_V 0.94 0.23 0.00
270_E 312_S 0.94 0.23 0.00
142_R 64_Q 0.93 0.23 0.00
86_L 307_S 0.93 0.22 0.00
225_F 327_D 0.92 0.22 0.00
86_L 140_T 0.92 0.22 0.00
122_G 334_L 0.91 0.21 0.00
72_D 377_A 0.91 0.21 0.00
57_R 331_I 0.90 0.21 0.00
218_V 330_Q 0.90 0.21 0.00
172_L 73_L 0.89 0.20 0.00
210_M 198_F 0.88 0.20 0.00
133_L 313_T 0.86 0.19 0.00
172_L 198_F 0.86 0.19 0.00
51_A 7_I 0.86 0.19 0.00
225_F 334_L 0.85 0.18 0.00
126_L 104_Q 0.85 0.18 0.00
152_L 331_I 0.85 0.18 0.00
184_K 57_N 0.84 0.18 0.00
145_A 24_G 0.84 0.18 0.00
51_A 104_Q 0.84 0.18 0.00
145_A 298_T 0.84 0.18 0.00
254_L 223_A 0.84 0.18 0.00
218_V 78_F 0.84 0.17 0.00
48_A 46_D 0.83 0.17 0.00
211_V 282_L 0.83 0.17 0.00
235_S 221_A 0.82 0.17 0.00
213_Q 321_L 0.81 0.16 0.00
55_Q 334_L 0.81 0.16 0.00
Figure 5: The i (protein A) and j (protein B) are positions as given in the query sequences.

Scaled Score = raw_score/average(raw_scores)
Prob = P(contact | scaled_score, seq/len)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)
ID Seq/Len Name Options I_Prob Status
4131 0.19 1XQR_A HspBP1 1S3X_A Hsp70 ATPase domain ATP Δgene:(1, 20) A:(1E-20, 8) B:(1E-20, 8) msa: Jackhmmer (2015_06) 0.00 Done - Shared
4085 0.7 1XQR_A HspBP1 1S3X_A Hsp70 ATPase domain ATP Δgene:(1, 20) A:(1E-04, 8) B:(1E-04, 8) msa: Jackhmmer (2015_06) 0.00 Done - Shared
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