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OPENSEQ.org
cIV_C_6_cI_H_10_Pdenitr
Genes: A B A+B
Length: 273 345 577
Sequences: 2876 4774 2501
Seq/Len: 10.53 13.84 4.33
MirrorTree (Pazo et al. 2001) 0.76
Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.

[Show Jackhmmer results] - Maybe useful in deciding what regions to trim.
Δgene Ratio of paralogs Joined
A B Seq/Len
1 0.00 0.00 0.08
2 0.00 0.00 0.28
5 0.00 0.00 0.60
10 0.00 0.01 3.35
20 0.00 0.01 3.49
100 0.00 0.02 3.58
∞ 0.01 0.05 4.05
Paired alignment generation
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Sequence A E-value:
Iterations:
Sequence B E-value:
Iterations:
Δgene MSA
Figure 1: The effect of Δgene on ratio of paralogs in the genome for each gene, and the number of sequences in the resulting joined alignment. Figure 2: Distribution of Δgene across all genomes. Figure 3: Current parameters. You can use the form to adjust the parameters and resubmit the job!
GREMLIN results (Scaled_score > 1):
Figure 4: The darker and larger the blue dots, the higher strength in coevolution. 		Inter Residue pairs sorted by strength in coevolution signal:
i j Scaled Score Prob I_Prob
62_M 325_V 1.07 0.82 0.05
267_V 301_Y 1.07 0.82 0.05
138_W 141_K 1.01 0.76 0.04
108_F 233_T 0.96 0.71 0.04
184_C 220_L 0.94 0.69 0.04
150_L 91_S 0.93 0.68 0.03
146_L 207_V 0.92 0.66 0.03
153_V 291_F 0.92 0.66 0.03
225_I 17_L 0.91 0.65 0.03
111_N 258_L 0.90 0.64 0.03
5_N 141_K 0.88 0.61 0.03
221_I 286_F 0.84 0.56 0.03
18_F 143_P 0.82 0.54 0.02
215_F 307_M 0.82 0.53 0.02
139_H 46_M 0.82 0.53 0.02
201_A 63_A 0.82 0.53 0.02
55_L 266_W 0.82 0.53 0.02
211_M 46_M 0.81 0.51 0.02
83_R 120_I 0.80 0.51 0.02
252_W 48_R 0.80 0.51 0.02
48_P 326_A 0.80 0.51 0.02
52_L 203_V 0.80 0.50 0.02
123_K 166_I 0.80 0.50 0.02
161_A 150_S 0.79 0.49 0.02
100_F 307_M 0.79 0.49 0.02
60_Y 121_F 0.79 0.49 0.02
12_P 65_A 0.79 0.48 0.02
37_G 130_G 0.78 0.48 0.02
140_L 298_V 0.78 0.48 0.02
95_M 111_A 0.78 0.47 0.02
90_F 58_L 0.77 0.46 0.02
123_K 73_I 0.75 0.44 0.02
265_F 92_M 0.74 0.43 0.02
57_G 221_V 0.74 0.43 0.02
190_A 317_L 0.74 0.43 0.02
142_L 274_A 0.74 0.42 0.02
228_F 21_A 0.74 0.42 0.02
135_F 216_P 0.74 0.42 0.02
35_M 42_A 0.74 0.42 0.02
221_I 309_I 0.73 0.41 0.02
84_I 102_I 0.73 0.41 0.02
60_Y 185_R 0.73 0.41 0.02
98_V 23_I 0.73 0.41 0.02
224_T 95_A 0.73 0.41 0.02
238_Q 56_W 0.73 0.41 0.02
225_I 102_I 0.73 0.41 0.02
236_K 266_W 0.72 0.40 0.02
6_H 59_L 0.72 0.40 0.02
6_H 62_F 0.72 0.39 0.02
180_I 117_I 0.72 0.39 0.02
34_W 238_T 0.71 0.39 0.02
21_A 102_I 0.71 0.39 0.02
56_V 21_A 0.71 0.39 0.02
222_I 123_A 0.71 0.39 0.02
229_V 86_L 0.71 0.39 0.02
146_L 169_I 0.71 0.38 0.02
170_T 258_L 0.71 0.38 0.02
125_G 167_G 0.71 0.38 0.02
195_H 299_P 0.71 0.38 0.02
140_L 223_A 0.71 0.38 0.02
130_E 169_I 0.71 0.38 0.02
22_I 65_A 0.70 0.38 0.02
166_G 284_M 0.70 0.38 0.01
191_Y 104_F 0.70 0.38 0.01
28_L 258_L 0.70 0.37 0.01
199_G 165_I 0.70 0.36 0.01
87_Q 151_A 0.69 0.36 0.01
224_T 22_V 0.69 0.36 0.01
126_V 16_L 0.69 0.36 0.01
162_F 148_L 0.69 0.36 0.01
23_G 76_P 0.69 0.36 0.01
50_M 26_V 0.69 0.35 0.01
77_E 204_L 0.69 0.35 0.01
207_G 270_V 0.69 0.35 0.01
108_F 97_F 0.69 0.35 0.01
242_K 317_L 0.69 0.35 0.01
228_F 55_P 0.68 0.35 0.01
21_A 162_G 0.68 0.35 0.01
102_V 282_I 0.68 0.35 0.01
27_M 28_G 0.68 0.35 0.01
166_G 17_L 0.68 0.34 0.01
84_I 97_F 0.68 0.34 0.01
Figure 5: The i (protein A) and j (protein B) are positions as given in the query sequences.

Scaled Score = raw_score/average(raw_scores)
Prob = P(contact | scaled_score, seq/len)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)
ID Seq/Len Name Options I_Prob Status
3186 4.31 cIV_C_2_cI_H_10_Pdenitr Δgene:(1, ∞) A:(1E-02, 8) B:(1E-10, 8) msa: Jackhmmer (2015_06) 0.04 Done - Shared
3185 4.33 cIV_C_6_cI_H_10_Pdenitr Δgene:(1, ∞) A:(1E-06, 8) B:(1E-10, 8) msa: Jackhmmer (2015_06) 0.05 Done - Shared
3184 4.3 cIV_C_4_cI_H_10_Pdenitr Δgene:(1, ∞) A:(1E-04, 8) B:(1E-10, 8) msa: Jackhmmer (2015_06) 0.07 Done - Shared
3183 4.35 cIV_C_4_cI_H_40_Pdenitr Δgene:(1, ∞) A:(1E-04, 8) B:(1E-40, 8) msa: Jackhmmer (2015_06) 0.05 Done - Shared
3182 4.25 cIV_C_20_cI_H_20_Pdenitr Δgene:(1, ∞) A:(1E-20, 8) B:(1E-20, 8) msa: Jackhmmer (2015_06) 0.02 Done - Shared
3181 4.35 cIV_C_4_cI_H_20_Pdenitr Δgene:(1, ∞) A:(1E-04, 8) B:(1E-20, 8) msa: Jackhmmer (2015_06) 0.06 Done - Shared
3180 4.35 cIV_C_4_cI_H_4_Pdenitr Δgene:(1, ∞) A:(1E-04, 8) B:(1E-04, 8) msa: Jackhmmer (2015_06) 0.04 Done - Shared
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