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OPENSEQ.org
cIV_C_20_cI_H_20_Pdenitr
Genes: A B A+B
Length: 273 345 577
Sequences: 2634 4758 2454
Seq/Len: 9.65 13.79 4.25
MirrorTree (Pazo et al. 2001) 0.81
Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.

[Show Jackhmmer results] - Maybe useful in deciding what regions to trim.
Δgene Ratio of paralogs Joined
A B Seq/Len
1 0.00 0.00 0.08
2 0.00 0.00 0.28
5 0.00 0.00 0.60
10 0.00 0.01 3.35
20 0.00 0.01 3.46
100 0.00 0.02 3.55
∞ 0.00 0.04 3.97
Paired alignment generation
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Sequence A E-value:
Iterations:
Sequence B E-value:
Iterations:
Δgene MSA
Figure 1: The effect of Δgene on ratio of paralogs in the genome for each gene, and the number of sequences in the resulting joined alignment. Figure 2: Distribution of Δgene across all genomes. Figure 3: Current parameters. You can use the form to adjust the parameters and resubmit the job!
GREMLIN results (Scaled_score > 1):
Figure 4: The darker and larger the blue dots, the higher strength in coevolution. 		Inter Residue pairs sorted by strength in coevolution signal:
i j Scaled Score Prob I_Prob
60_Y 121_F 1.02 0.77 0.02
267_V 301_Y 1.01 0.76 0.02
62_M 325_V 1.00 0.75 0.02
146_L 207_V 0.98 0.73 0.02
138_W 141_K 0.97 0.71 0.02
108_F 233_T 0.94 0.68 0.02
184_C 220_L 0.93 0.67 0.02
211_M 46_M 0.91 0.65 0.02
153_V 291_F 0.89 0.62 0.02
215_F 307_M 0.89 0.62 0.02
83_R 120_I 0.88 0.60 0.02
225_I 17_L 0.87 0.59 0.01
95_M 111_A 0.86 0.58 0.01
225_I 102_I 0.85 0.57 0.01
52_L 203_V 0.85 0.56 0.01
139_H 46_M 0.84 0.56 0.01
221_I 286_F 0.84 0.55 0.01
111_N 258_L 0.84 0.55 0.01
153_V 260_L 0.83 0.55 0.01
18_F 143_P 0.83 0.54 0.01
12_P 65_A 0.83 0.54 0.01
90_F 58_L 0.83 0.53 0.01
98_V 23_I 0.81 0.52 0.01
56_V 21_A 0.81 0.52 0.01
5_N 141_K 0.81 0.51 0.01
177_V 19_G 0.81 0.51 0.01
180_I 117_I 0.81 0.51 0.01
55_L 266_W 0.80 0.50 0.01
161_A 150_S 0.80 0.50 0.01
100_F 307_M 0.80 0.50 0.01
102_V 282_I 0.80 0.49 0.01
28_L 258_L 0.79 0.48 0.01
25_F 183_A 0.78 0.48 0.01
169_K 24_A 0.78 0.47 0.01
50_M 26_V 0.78 0.47 0.01
48_P 326_A 0.78 0.47 0.01
142_L 274_A 0.78 0.47 0.01
191_Y 104_F 0.77 0.46 0.01
34_W 238_T 0.77 0.46 0.01
34_W 55_P 0.77 0.46 0.01
140_L 298_V 0.77 0.46 0.01
149_L 173_G 0.77 0.46 0.01
224_T 22_V 0.77 0.45 0.01
23_G 76_P 0.76 0.45 0.01
180_I 175_M 0.76 0.44 0.01
35_M 42_A 0.76 0.44 0.01
252_W 48_R 0.75 0.44 0.01
171_T 207_V 0.75 0.43 0.01
87_Q 151_A 0.75 0.43 0.01
6_H 62_F 0.75 0.43 0.01
13_P 124_S 0.75 0.43 0.01
146_L 169_I 0.75 0.43 0.01
149_L 250_A 0.74 0.42 0.01
224_T 95_A 0.74 0.42 0.01
138_W 179_A 0.74 0.41 0.01
87_Q 252_Y 0.73 0.41 0.01
238_Q 56_W 0.73 0.41 0.01
130_E 169_I 0.73 0.41 0.01
21_A 164_I 0.73 0.41 0.01
91_I 170_I 0.73 0.41 0.01
21_A 147_S 0.73 0.40 0.01
204_V 309_I 0.73 0.40 0.01
56_V 20_L 0.73 0.40 0.01
22_I 65_A 0.73 0.40 0.01
108_F 97_F 0.73 0.40 0.01
135_F 216_P 0.72 0.40 0.01
54_G 116_G 0.72 0.40 0.01
37_G 130_G 0.72 0.39 0.01
84_I 97_F 0.72 0.39 0.01
201_A 63_A 0.72 0.39 0.01
221_I 309_I 0.72 0.39 0.01
171_T 42_A 0.72 0.39 0.01
80_P 28_G 0.71 0.39 0.01
190_A 198_H 0.71 0.39 0.01
205_Y 170_I 0.71 0.38 0.01
174_G 170_I 0.71 0.38 0.01
99_M 102_I 0.71 0.38 0.01
77_E 204_L 0.71 0.38 0.01
138_W 198_H 0.71 0.38 0.01
31_A 330_R 0.71 0.38 0.01
123_K 73_I 0.71 0.38 0.01
103_A 216_P 0.71 0.38 0.01
149_L 289_Y 0.71 0.37 0.01
75_T 33_M 0.70 0.37 0.01
54_G 168_I 0.70 0.37 0.01
102_V 97_F 0.70 0.37 0.01
267_V 29_S 0.70 0.36 0.01
84_I 102_I 0.70 0.36 0.01
128_P 136_W 0.69 0.36 0.01
55_L 201_M 0.69 0.36 0.01
229_V 86_L 0.69 0.35 0.01
190_A 317_L 0.69 0.35 0.01
21_A 102_I 0.69 0.35 0.01
80_P 58_L 0.69 0.35 0.01
6_H 59_L 0.69 0.35 0.01
212_A 312_K 0.69 0.35 0.01
108_F 65_A 0.69 0.35 0.01
138_W 125_S 0.69 0.35 0.01
199_G 165_I 0.69 0.35 0.01
150_L 91_S 0.69 0.35 0.01
244_H 129_Y 0.69 0.35 0.01
265_F 92_M 0.69 0.35 0.01
228_F 21_A 0.69 0.35 0.01
170_T 258_L 0.69 0.35 0.01
131_G 301_Y 0.68 0.35 0.01
70_V 100_V 0.68 0.34 0.01
121_P 321_W 0.68 0.34 0.01
229_V 85_F 0.68 0.34 0.01
203_T 249_I 0.68 0.34 0.01
27_M 186_G 0.68 0.34 0.01
187_G 246_G 0.68 0.34 0.01
150_L 134_G 0.68 0.34 0.01
166_G 20_L 0.67 0.33 0.01
38_I 233_T 0.67 0.33 0.01
232_I 167_G 0.67 0.33 0.01
179_V 15_M 0.67 0.33 0.01
10_I 197_P 0.67 0.33 0.01
Figure 5: The i (protein A) and j (protein B) are positions as given in the query sequences.

Scaled Score = raw_score/average(raw_scores)
Prob = P(contact | scaled_score, seq/len)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)
ID Seq/Len Name Options I_Prob Status
3186 4.31 cIV_C_2_cI_H_10_Pdenitr Δgene:(1, ∞) A:(1E-02, 8) B:(1E-10, 8) msa: Jackhmmer (2015_06) 0.04 Done - Shared
3185 4.33 cIV_C_6_cI_H_10_Pdenitr Δgene:(1, ∞) A:(1E-06, 8) B:(1E-10, 8) msa: Jackhmmer (2015_06) 0.05 Done - Shared
3184 4.3 cIV_C_4_cI_H_10_Pdenitr Δgene:(1, ∞) A:(1E-04, 8) B:(1E-10, 8) msa: Jackhmmer (2015_06) 0.07 Done - Shared
3183 4.35 cIV_C_4_cI_H_40_Pdenitr Δgene:(1, ∞) A:(1E-04, 8) B:(1E-40, 8) msa: Jackhmmer (2015_06) 0.05 Done - Shared
3182 4.25 cIV_C_20_cI_H_20_Pdenitr Δgene:(1, ∞) A:(1E-20, 8) B:(1E-20, 8) msa: Jackhmmer (2015_06) 0.02 Done - Shared
3181 4.35 cIV_C_4_cI_H_20_Pdenitr Δgene:(1, ∞) A:(1E-04, 8) B:(1E-20, 8) msa: Jackhmmer (2015_06) 0.06 Done - Shared
3180 4.35 cIV_C_4_cI_H_4_Pdenitr Δgene:(1, ∞) A:(1E-04, 8) B:(1E-04, 8) msa: Jackhmmer (2015_06) 0.04 Done - Shared
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