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OPENSEQ.org
cI_I_40_cIII_isp_10_Pdenitr
Genes: A B A+B
Length: 163 190 346
Sequences: 644 1539 376
Seq/Len: 3.95 8.1 1.09
MirrorTree (Pazo et al. 2001) 0.72
Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.

[Show Jackhmmer results] - Maybe useful in deciding what regions to trim.
Δgene Ratio of paralogs Joined
A B Seq/Len
1 0.00 0.01 0.00
2 0.00 0.01 0.00
5 0.00 0.01 0.00
10 0.00 0.01 0.00
20 0.00 0.01 0.01
100 0.00 0.01 0.07
∞ 0.01 0.04 1.07
Paired alignment generation
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Sequence A E-value:
Iterations:
Sequence B E-value:
Iterations:
Δgene MSA
Figure 1: The effect of Δgene on ratio of paralogs in the genome for each gene, and the number of sequences in the resulting joined alignment. Figure 2: Distribution of Δgene across all genomes. Figure 3: Current parameters. You can use the form to adjust the parameters and resubmit the job!
GREMLIN results (Scaled_score > 1):
Figure 4: The darker and larger the blue dots, the higher strength in coevolution. 		Inter Residue pairs sorted by strength in coevolution signal:
i j Scaled Score Prob I_Prob
27_Y 34_A 1.66 0.88 0.19
156_L 47_D 1.27 0.61 0.06
12_F 131_V 1.27 0.61 0.06
155_N 72_L 1.14 0.49 0.04
12_F 25_G 1.12 0.47 0.04
20_G 41_Q 1.12 0.47 0.04
108_F 188_K 1.09 0.44 0.04
25_M 131_V 1.08 0.43 0.03
18_I 28_T 1.07 0.42 0.03
13_L 13_A 1.07 0.42 0.03
150_A 144_A 1.06 0.42 0.03
4_D 31_A 1.03 0.38 0.03
29_V 10_D 1.02 0.38 0.03
5_F 31_A 1.01 0.37 0.03
141_L 170_A 1.01 0.37 0.03
8_A 28_T 0.99 0.35 0.03
161_P 61_V 0.99 0.35 0.03
160_A 29_V 0.99 0.35 0.03
21_F 38_L 0.99 0.35 0.03
12_F 66_Q 0.99 0.35 0.02
140_K 50_A 0.97 0.33 0.02
9_T 60_G 0.95 0.32 0.02
143_A 131_V 0.95 0.32 0.02
156_L 45_S 0.93 0.30 0.02
58_P 18_F 0.92 0.29 0.02
131_R 23_T 0.92 0.29 0.02
160_A 22_A 0.92 0.29 0.02
37_Y 78_I 0.91 0.28 0.02
141_L 157_S 0.91 0.28 0.02
59_N 162_S 0.90 0.28 0.02
121_G 77_F 0.90 0.28 0.02
10_K 131_V 0.90 0.28 0.02
13_L 59_S 0.90 0.28 0.02
26_R 23_T 0.89 0.27 0.02
157_Q 19_L 0.89 0.27 0.02
135_F 33_A 0.88 0.27 0.02
156_L 144_A 0.88 0.26 0.02
18_I 18_F 0.88 0.26 0.02
11_Y 131_V 0.88 0.26 0.02
19_K 29_V 0.88 0.26 0.02
9_T 143_G 0.87 0.26 0.01
90_S 47_D 0.87 0.26 0.01
28_F 34_A 0.86 0.25 0.01
136_Y 18_F 0.86 0.25 0.01
48_F 33_A 0.86 0.25 0.01
44_L 80_R 0.85 0.24 0.01
35_L 57_D 0.85 0.24 0.01
33_P 41_Q 0.85 0.24 0.01
94_T 59_S 0.85 0.24 0.01
136_Y 168_G 0.85 0.24 0.01
31_P 125_W 0.85 0.24 0.01
11_Y 35_A 0.84 0.23 0.01
82_D 158_H 0.84 0.23 0.01
11_Y 178_V 0.83 0.23 0.01
41_K 91_E 0.83 0.23 0.01
22_G 175_H 0.83 0.23 0.01
15_W 10_D 0.83 0.23 0.01
8_A 32_G 0.83 0.23 0.01
37_Y 28_T 0.83 0.23 0.01
6_A 35_A 0.82 0.22 0.01
90_S 45_S 0.82 0.22 0.01
89_G 124_E 0.82 0.22 0.01
125_E 15_R 0.82 0.22 0.01
17_F 23_T 0.82 0.22 0.01
87_E 31_A 0.81 0.22 0.01
18_I 34_A 0.81 0.22 0.01
143_A 184_D 0.81 0.21 0.01
122_P 168_G 0.81 0.21 0.01
12_F 19_L 0.81 0.21 0.01
26_R 22_A 0.81 0.21 0.01
134_L 42_M 0.80 0.21 0.01
112_A 8_A 0.80 0.21 0.01
118_I 177_P 0.79 0.20 0.01
157_Q 35_A 0.79 0.20 0.01
39_H 150_W 0.79 0.20 0.01
10_K 90_R 0.79 0.20 0.01
136_Y 67_L 0.79 0.20 0.01
5_F 32_G 0.79 0.20 0.01
100_M 150_W 0.78 0.20 0.01
48_F 178_V 0.78 0.20 0.01
147_R 175_H 0.78 0.20 0.01
112_A 186_T 0.78 0.20 0.01
59_N 37_T 0.78 0.20 0.01
16_D 61_V 0.78 0.20 0.01
29_V 176_I 0.78 0.19 0.01
90_S 100_R 0.78 0.19 0.01
40_E 39_V 0.77 0.19 0.01
157_Q 124_E 0.77 0.19 0.01
135_F 13_A 0.77 0.19 0.01
160_A 128_M 0.77 0.19 0.01
105_Y 43_N 0.77 0.19 0.01
21_F 131_V 0.77 0.19 0.01
23_L 88_A 0.77 0.19 0.01
Figure 5: The i (protein A) and j (protein B) are positions as given in the query sequences.

Scaled Score = raw_score/average(raw_scores)
Prob = P(contact | scaled_score, seq/len)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)
ID Seq/Len Name Options I_Prob Status
3050 1.29 cI_I_20_cIII_isp_10_Pdenitr Δgene:(1, ∞) A:(1E-20, 8) B:(1E-10, 8) msa: Jackhmmer (2015_06) 0.00 Done - Shared
3049 0.71 cI_I_60_cIII_isp_10_Pdenitr Δgene:(1, ∞) A:(1E-60, 8) B:(1E-10, 8) msa: Jackhmmer (2015_06) 0.01 Done - Shared
3048 0.78 cI_I_40_cIII_isp_20_Pdenitr Δgene:(1, ∞) A:(1E-40, 8) B:(1E-20, 8) msa: Jackhmmer (2015_06) 0.00 Done - Shared
3047 1.09 cI_I_40_cIII_isp_10_Pdenitr Δgene:(1, ∞) A:(1E-40, 8) B:(1E-10, 8) msa: Jackhmmer (2015_06) 0.19 Done - Shared
3046 1.11 cI_I_40_cIII_isp_6_Pdenitr Δgene:(1, ∞) A:(1E-40, 8) B:(1E-06, 8) msa: Jackhmmer (2015_06) 0.03 Done - Shared
3044 1.11 cI_I_40_cIII_isp_4_Pdenitr Δgene:(1, ∞) A:(1E-40, 8) B:(1E-04, 8) msa: Jackhmmer (2015_06) 0.00 Done - Shared
3043 1.84 cI_I_4_cIII_isp_4_Pdenitr Δgene:(1, ∞) A:(1E-04, 8) B:(1E-04, 8) msa: Jackhmmer (2015_06) 0.00 Done - Shared
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