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OPENSEQ.org

ACCC - HOA
UniProt: P24182 - P51020
Length: 786
Sequences: 569
Seq/Len: 0.76
I_Prob: 0.00

ACCC - Biotin carboxylase
Paralog alert: 0.87 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: ACCC DDLA DDLB GSHB PUR2 PURK PURT RIMK
HOA - 4-hydroxy-2-oxovalerate aldolase
Paralog alert: 0.55 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: HOA
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
1nvmAECG:BFHDContact Map
4lrtAC:BDContact Map


Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
17_I 231_A 1.32 0.00
103_I 181_F 1.30 0.00
427_D 223_S 1.22 0.00
45_A 166_V 1.17 0.00
250_P 130_G 1.08 0.00
210_V 231_A 1.03 0.00
78_I 109_V 1.02 0.00
216_A 246_L 1.01 0.00
268_G 131_M 1.00 0.00
28_T 158_Y 0.98 0.00
313_L 181_F 0.97 0.00
433_G 265_V 0.96 0.00
425_M 240_I 0.96 0.00
106_K 7_Y 0.95 0.00
428_E 78_K 0.95 0.00
267_I 231_A 0.93 0.00
418_V 157_G 0.93 0.00
17_I 21_R 0.92 0.00
24_L 218_D 0.89 0.00
158_I 154_L 0.87 0.00
26_I 217_C 0.87 0.00
48_T 194_T 0.87 0.00
158_I 43_S 0.87 0.00
200_M 212_A 0.87 0.00
424_I 112_H 0.86 0.00
99_G 130_G 0.85 0.00
49_V 97_K 0.85 0.00
62_N 37_D 0.85 0.00
380_Y 158_Y 0.84 0.00
189_A 43_S 0.84 0.00
107_A 124_Q 0.84 0.00
279_F 181_F 0.84 0.00
407_Q 186_A 0.83 0.00
306_V 30_R 0.83 0.00
76_V 4_K 0.83 0.00
125_K 146_E 0.83 0.00
223_I 243_A 0.83 0.00
18_L 166_V 0.82 0.00
261_A 112_H 0.82 0.00
377_V 179_D 0.82 0.00
216_A 96_L 0.82 0.00
246_P 183_A 0.82 0.00
120_I 56_S 0.82 0.00
200_M 131_M 0.82 0.00
195_N 47_A 0.81 0.00
45_A 108_R 0.81 0.00
409_L 231_A 0.81 0.00
100_F 123_I 0.81 0.00
210_V 104_A 0.81 0.00
343_D 165_V 0.81 0.00
51_I 149_A 0.81 0.00
372_Y 70_I 0.81 0.00
399_I 109_V 0.80 0.00
68_S 188_L 0.80 0.00
394_N 35_A 0.80 0.00
76_V 81_K 0.80 0.00
152_I 212_A 0.80 0.00
103_I 78_K 0.80 0.00
262_K 210_I 0.80 0.00
67_I 210_I 0.79 0.00
45_A 164_Y 0.79 0.00
383_S 136_F 0.79 0.00
127_G 8_I 0.79 0.00
304_T 30_R 0.79 0.00
343_D 108_R 0.79 0.00
5_I 186_A 0.79 0.00
331_R 112_H 0.78 0.00
204_L 181_F 0.78 0.00
108_E 239_F 0.78 0.00
21_C 149_A 0.78 0.00
143_D 101_Q 0.78 0.00
343_D 164_Y 0.78 0.00
180_Q 220_I 0.78 0.00
150_K 252_T 0.78 0.00
26_I 211_A 0.78 0.00
200_M 145_P 0.77 0.00
176_A 31_Q 0.77 0.00
293_I 138_M 0.77 0.00
377_V 236_L 0.77 0.00
162_G 24_Y 0.76 0.00
115_D 141_H 0.75 0.00
200_M 153_K 0.75 0.00
418_V 34_K 0.75 0.00
103_I 186_A 0.75 0.00
377_V 244_D 0.75 0.00
53_P 150_K 0.75 0.00
111_R 101_Q 0.74 0.00
204_L 252_T 0.74 0.00
306_V 194_T 0.74 0.00
54_A 48_H 0.74 0.00
339_I 75_D 0.74 0.00
383_S 165_V 0.74 0.00
427_D 212_A 0.74 0.00
78_I 242_A 0.74 0.00
103_I 28_N 0.74 0.00
101_I 253_D 0.73 0.00
401_R 253_D 0.73 0.00
250_P 107_V 0.73 0.00
35_A 181_F 0.73 0.00
158_I 104_A 0.73 0.00
196_D 261_A 0.73 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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