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OPENSEQ.org
YKFC - Putative uncharacterized protein YkfC
UniProt: Q47688 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13341
Length: 376 (365)
Sequences: 1412
Seq/Len: 3.87
YKFC
Paralog alert: 0.43 [within 20: 0.09] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
164_S 168_T 4.314 1.00
289_K 293_E 3.533 1.00
163_S 310_R 3.43 1.00
178_V 225_I 2.913 1.00
85_Y 93_L 2.758 1.00
168_T 210_E 2.731 1.00
283_L 299_C 2.696 1.00
164_S 167_D 2.49 1.00
99_P 216_G 2.452 1.00
180_R 229_E 2.431 1.00
111_L 115_E 2.245 1.00
129_F 278_A 2.232 1.00
108_R 111_L 2.216 1.00
160_G 281_F 2.144 1.00
300_R 313_M 2.117 1.00
127_Y 137_H 2.107 1.00
296_R 300_R 2.056 1.00
126_S 276_R 1.97 1.00
174_L 222_L 1.962 1.00
230_F 299_C 1.958 1.00
85_Y 201_D 1.947 1.00
139_I 332_L 1.901 1.00
199_H 208_A 1.896 1.00
90_N 314_D 1.892 1.00
228_N 232_Q 1.884 1.00
70_E 102_R 1.843 1.00
46_P 50_G 1.812 0.99
142_V 284_I 1.803 0.99
231_D 276_R 1.788 0.99
162_L 312_N 1.736 0.99
119_E 130_R 1.714 0.99
349_P 352_K 1.648 0.99
172_R 192_W 1.624 0.99
139_I 330_H 1.62 0.99
121_D 181_R 1.617 0.99
170_H 308_K 1.609 0.99
213_P 216_G 1.595 0.98
160_G 311_L 1.593 0.98
173_L 308_K 1.589 0.98
158_I 292_V 1.585 0.98
29_W 112_M 1.583 0.98
175_M 192_W 1.582 0.98
175_M 188_M 1.58 0.98
356_F 359_S 1.564 0.98
74_G 186_R 1.548 0.98
198_G 208_A 1.536 0.98
83_R 95_P 1.516 0.98
40_S 43_A 1.504 0.97
92_K 164_S 1.497 0.97
123_H 235_H 1.482 0.97
179_R 185_A 1.481 0.97
165_Y 169_V 1.477 0.97
326_I 331_R 1.475 0.97
81_A 97_G 1.474 0.97
116_P 221_L 1.458 0.97
169_V 174_L 1.457 0.97
350_Q 353_A 1.451 0.97
118_W 225_I 1.443 0.96
227_L 276_R 1.426 0.96
311_L 316_T 1.409 0.96
110_M 187_F 1.406 0.96
211_G 214_Q 1.399 0.96
349_P 353_A 1.398 0.96
78_P 193_K 1.393 0.95
122_F 228_N 1.389 0.95
165_Y 168_T 1.37 0.95
230_F 302_V 1.363 0.95
160_G 316_T 1.357 0.95
30_L 109_A 1.354 0.94
224_N 276_R 1.351 0.94
157_V 284_I 1.346 0.94
97_G 216_G 1.33 0.94
85_Y 95_P 1.3 0.93
172_R 176_K 1.298 0.93
173_L 307_L 1.298 0.93
89_S 92_K 1.29 0.92
165_Y 223_S 1.281 0.92
158_I 316_T 1.28 0.92
68_R 72_L 1.274 0.92
163_S 168_T 1.274 0.92
126_S 227_L 1.268 0.92
129_F 220_P 1.256 0.91
288_T 291_Q 1.256 0.91
123_H 228_N 1.253 0.91
211_G 215_G 1.248 0.91
169_V 212_V 1.24 0.90
115_E 131_P 1.233 0.90
53_K 101_L 1.232 0.90
63_E 102_R 1.232 0.90
107_Q 216_G 1.219 0.89
111_L 221_L 1.218 0.89
21_L 24_I 1.214 0.89
250_W 265_N 1.21 0.89
280_D 315_K 1.209 0.89
88_K 214_Q 1.208 0.89
324_G 331_R 1.207 0.89
237_R 298_E 1.204 0.89
21_L 71_L 1.203 0.88
92_K 314_D 1.195 0.88
178_V 191_L 1.193 0.88
81_A 216_G 1.186 0.87
6_A 9_A 1.183 0.87
108_R 217_V 1.175 0.87
179_R 192_W 1.166 0.86
126_S 224_N 1.16 0.86
69_D 73_S 1.156 0.86
3_R 6_A 1.151 0.85
177_A 228_N 1.147 0.85
105_I 109_A 1.137 0.84
142_V 282_V 1.135 0.84
214_Q 220_P 1.132 0.84
48_V 80_P 1.129 0.84
282_V 325_F 1.123 0.83
50_G 132_E 1.12 0.83
27_P 65_Q 1.116 0.83
83_R 208_A 1.113 0.83
174_L 212_V 1.111 0.82
304_E 310_R 1.11 0.82
79_L 100_A 1.107 0.82
11_T 16_R 1.102 0.82
135_V 277_Y 1.098 0.81
107_Q 138_A 1.096 0.81
168_T 310_R 1.095 0.81
251_N 254_I 1.091 0.81
4_K 7_T 1.089 0.81
22_R 26_Q 1.088 0.81
48_V 100_A 1.084 0.80
87_P 93_L 1.083 0.80
8_W 12_D 1.074 0.79
118_W 182_I 1.073 0.79
357_A 361_T 1.068 0.79
232_Q 235_H 1.067 0.79
178_V 188_M 1.067 0.79
106_V 194_T 1.06 0.78
226_M 230_F 1.06 0.78
173_L 226_M 1.056 0.78
9_A 15_L 1.055 0.78
23_L 26_Q 1.055 0.78
177_A 229_E 1.053 0.77
290_A 293_E 1.052 0.77
159_E 319_P 1.051 0.77
275_C 284_I 1.05 0.77
141_T 145_Q 1.046 0.77
115_E 119_E 1.045 0.77
42_G 45_T 1.045 0.77
224_N 227_L 1.044 0.77
24_I 113_A 1.039 0.76
209_S 293_E 1.037 0.76
127_Y 138_A 1.033 0.76
5_L 8_W 1.032 0.75
88_K 315_K 1.031 0.75
247_R 250_W 1.03 0.75
88_K 211_G 1.028 0.75
34_A 105_I 1.026 0.75
257_G 260_T 1.024 0.75
157_V 325_F 1.022 0.74
163_S 312_N 1.016 0.74
122_F 225_I 1.016 0.74
175_M 195_I 1.016 0.74
60_L 63_E 1.013 0.74
33_A 112_M 1.012 0.73
134_S 137_H 1.01 0.73
9_A 16_R 1.006 0.73
233_Y 236_E 1.006 0.73
301_G 305_G 1.005 0.73
162_L 309_L 1.003 0.73
252_N 264_E 1.002 0.72
66_I 70_E 1.002 0.72
355_N 362_A 1.002 0.72
251_N 256_R 1 0.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3kylA10.82451000.579Contact Map0.529
1xr5A10.85641000.659Contact Map0.31
3fsiA10.651699.60.814Contact Map0.454
3bsoA10.861799.40.844Contact Map0.408
3n6mA10.856499.30.848Contact Map0.295
1rw3A10.726199.30.853Contact Map0.447
3uqsA30.861799.20.859Contact Map0.417
1ra6A10.864499.10.861Contact Map0.366
4g1qB10.688899.10.862Contact Map0.431
2ckwA10.88399.10.865Contact Map0.443
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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