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OPENSEQ.org
DDPX - D-alanyl-D-alanine dipeptidase
UniProt: P77790 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13791
Length: 193 (179)
Sequences: 490
Seq/Len: 2.74
DDPX
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
22_K 27_D 3.586 1.00
40_C 69_A 2.935 1.00
65_V 115_I 2.739 1.00
131_A 166_F 2.659 1.00
137_P 140_A 2.494 1.00
131_A 158_G 2.345 1.00
42_L 46_A 2.242 1.00
34_I 79_L 2.121 1.00
56_I 153_G 1.997 1.00
65_V 107_T 1.959 0.99
136_V 140_A 1.924 0.99
88_Y 130_H 1.903 0.99
75_A 99_S 1.889 0.99
103_A 167_E 1.889 0.99
54_I 63_Q 1.846 0.99
116_L 143_N 1.817 0.99
57_A 150_I 1.803 0.99
10_L 17_L 1.8 0.99
52_K 154_G 1.796 0.99
66_I 69_A 1.793 0.99
53_S 154_G 1.703 0.98
32_K 78_M 1.691 0.98
117_D 140_A 1.657 0.98
119_G 144_R 1.655 0.98
17_L 66_I 1.647 0.97
62_L 116_L 1.621 0.97
56_I 154_G 1.583 0.97
10_L 19_I 1.557 0.96
13_I 51_A 1.526 0.95
9_D 39_R 1.51 0.95
146_L 150_I 1.493 0.95
49_A 168_L 1.462 0.94
67_Y 115_I 1.455 0.94
43_H 102_T 1.453 0.94
57_A 108_L 1.406 0.92
53_S 151_M 1.391 0.92
10_L 14_F 1.356 0.90
80_W 86_P 1.354 0.90
42_L 88_Y 1.348 0.90
65_V 109_R 1.342 0.90
14_F 17_L 1.333 0.89
18_E 65_V 1.322 0.89
80_W 84_P 1.32 0.88
63_Q 109_R 1.281 0.86
23_Y 123_D 1.272 0.86
125_M 129_S 1.272 0.86
13_I 47_I 1.271 0.86
90_V 96_S 1.263 0.85
73_Q 77_A 1.261 0.85
97_N 167_E 1.255 0.85
16_D 58_Q 1.23 0.83
119_G 136_V 1.206 0.82
80_W 91_D 1.202 0.81
45_D 49_A 1.196 0.81
107_T 118_M 1.193 0.81
124_E 128_R 1.184 0.80
131_A 148_N 1.182 0.80
136_V 141_Q 1.172 0.79
9_D 12_V 1.152 0.77
53_S 56_I 1.14 0.76
110_D 114_N 1.138 0.76
151_M 156_F 1.128 0.75
110_D 113_G 1.122 0.75
64_L 106_L 1.111 0.74
80_W 83_C 1.107 0.73
7_L 177_L 1.103 0.73
18_E 109_R 1.097 0.72
7_L 43_H 1.097 0.72
22_K 25_C 1.082 0.71
57_A 64_L 1.082 0.71
9_D 41_L 1.082 0.71
30_T 78_M 1.077 0.70
73_Q 99_S 1.069 0.69
21_L 38_A 1.069 0.69
34_I 75_A 1.066 0.69
59_L 176_L 1.063 0.69
121_G 124_E 1.059 0.68
20_E 24_A 1.051 0.68
8_V 117_D 1.041 0.66
53_S 150_I 1.04 0.66
54_I 104_I 1.035 0.66
9_D 166_F 1.035 0.66
108_L 124_E 1.032 0.65
70_Y 100_R 1.032 0.65
61_G 109_R 1.027 0.65
21_L 69_A 1.017 0.64
131_A 144_R 1.011 0.63
64_L 147_L 1 0.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1r44A60.92231000.303Contact Map0.738
4jidA20.84971000.644Contact Map0.426
4mphA20.834299.90.659Contact Map0.456
4murA20.896499.90.671Contact Map0.581
4muqA10.88699.90.676Contact Map0.536
4f78A10.88699.90.676Contact Map0.514
1xp2A30.818799.70.764Contact Map0.569
2ibgE40.590780.70.94Contact Map0.77
3n1gB20.647773.50.943Contact Map0.669
3k7iB10.678860.70.948Contact Map0.606
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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