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OPENSEQ.org

YDII - Esterase YdiI
UniProt: P77781 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13968
Length: 136 (128)
Sequences: 3028
Seq/Len: 23.66

YDII
Paralog alert: 0.55 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: ENTH PAAI YDII YIGI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
83_L 111_H 3.337 1.00
29_E 39_T 3.069 1.00
39_T 97_R 2.938 1.00
37_E 101_V 2.621 1.00
101_V 119_F 2.517 1.00
27_R 39_T 2.49 1.00
30_H 35_T 2.463 1.00
38_A 65_I 2.456 1.00
30_H 37_E 2.361 1.00
40_M 57_A 2.149 1.00
70_G 112_Q 2.027 1.00
32_G 35_T 2.025 1.00
117_E 125_L 1.964 1.00
62_A 129_S 1.94 1.00
35_T 103_K 1.922 1.00
59_V 85_I 1.918 1.00
91_R 124_R 1.843 1.00
66_G 116_I 1.791 1.00
65_I 100_G 1.789 1.00
35_T 101_V 1.763 1.00
59_V 89_H 1.734 1.00
84_E 88_N 1.694 1.00
120_D 124_R 1.681 1.00
39_T 99_R 1.634 1.00
66_G 131_L 1.617 1.00
59_V 87_A 1.601 1.00
100_G 116_I 1.55 1.00
37_E 99_R 1.503 1.00
103_K 117_E 1.495 1.00
103_K 115_Q 1.494 1.00
115_Q 128_S 1.469 1.00
62_A 118_I 1.438 1.00
41_P 97_R 1.432 1.00
42_V 53_L 1.403 0.99
106_H 111_H 1.403 0.99
119_F 123_G 1.394 0.99
104_P 107_L 1.381 0.99
58_S 127_C 1.374 0.99
62_A 116_I 1.371 0.99
93_A 126_C 1.366 0.99
105_L 115_Q 1.357 0.99
20_M 57_A 1.353 0.99
87_A 127_C 1.323 0.99
23_F 45_R 1.273 0.99
34_D 72_L 1.234 0.98
63_E 82_G 1.23 0.98
56_G 60_V 1.226 0.98
115_Q 130_R 1.21 0.98
117_E 128_S 1.19 0.98
53_L 98_V 1.187 0.98
43_D 46_T 1.171 0.98
27_R 41_P 1.165 0.97
73_C 107_L 1.152 0.97
105_L 128_S 1.144 0.97
29_E 37_E 1.142 0.97
58_S 118_I 1.128 0.97
58_S 126_C 1.12 0.96
88_N 132_T 1.067 0.95
70_G 133_T 1.066 0.95
84_E 130_R 1.056 0.95
20_M 60_V 1.055 0.95
10_E 14_A 1.048 0.94
91_R 106_H 1.042 0.94
93_A 98_V 1.041 0.94
52_L 81_V 1.031 0.94
90_V 128_S 1.026 0.94
104_P 114_W 1.008 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vh5A2199.90.252Contact Map0.85
1vh9A2199.90.254Contact Map0.735
3lmbA20.985399.90.259Contact Map0.689
1yocA20.992699.90.274Contact Map0.637
1sh8A20.970699.90.277Contact Map0.724
1o0iA2199.90.279Contact Map0.795
1t82A40.977999.90.284Contact Map0.649
3e8pA4199.90.289Contact Map0.802
3gekA40.87599.90.29Contact Map0.846
3hduA3199.90.3Contact Map0.751

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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