OPENSEQ.org - YEES - ECOLI GREMLIN

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YEES - UPF0758 protein YeeS

UniProt:	P76362	Sequence MTPGERSLIQRALKTLDRHLHEPGVAFTSTRAAREWLILNMAGLEREEFRVLYLNNQNQLIAGETLFTGTINRTEVHPREVIKRALYHNAAAVVLAHNHPSGEVTPSKADRLITERLVQALGLVDIRVPDHLIVGGNQVFSFAEHGLL	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG13386
Length:	148 (141)
Sequences:	1816
Seq/Len:	12.88

YEES
Paralog alert: 0.27 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: YEES YFJY YICR YKFG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
95_L	128_V	2.799	1.00
82_I	121_L	2.674	1.00
64_E	84_R	2.461	1.00
55_N	59_Q	2.435	1.00
140_F	145_H	2.4	1.00
37_L	96_A	2.324	1.00
111_R	142_F	2.318	1.00
71_I	91_A	2.096	1.00
111_R	147_L	1.903	1.00
41_M	44_L	1.855	1.00
46_R	68_T	1.816	1.00
95_L	117_L	1.811	1.00
27_F	60_L	1.776	1.00
118_V	128_V	1.765	1.00
114_T	131_H	1.735	1.00
115_E	119_Q	1.704	1.00
108_K	112_L	1.702	1.00
56_N	72_N	1.645	1.00
28_T	32_A	1.642	1.00
83_K	89_N	1.622	1.00
50_R	63_G	1.574	1.00
81_V	117_L	1.549	1.00
48_E	65_T	1.537	1.00
62_A	88_H	1.529	1.00
53_Y	84_R	1.519	1.00
50_R	65_T	1.515	1.00
67_F	74_T	1.504	1.00
52_L	60_L	1.491	1.00
65_T	68_T	1.485	1.00
30_T	144_E	1.441	1.00
119_Q	122_G	1.413	1.00
53_Y	88_H	1.412	1.00
49_F	128_V	1.41	1.00
82_I	124_V	1.399	0.99
41_M	50_R	1.352	0.99
57_Q	103_E	1.349	0.99
49_F	76_V	1.337	0.99
31_R	35_E	1.326	0.99
104_V	138_Q	1.305	0.99
84_R	87_Y	1.305	0.99
42_A	136_G	1.303	0.99
108_K	111_R	1.3	0.99
142_F	148_L	1.291	0.99
76_V	113_I	1.291	0.99
85_A	93_V	1.29	0.99
14_K	18_R	1.285	0.99
45_E	83_K	1.254	0.99
84_R	88_H	1.251	0.99
48_E	68_T	1.246	0.98
46_R	67_F	1.231	0.98
85_A	126_I	1.228	0.98
104_V	140_F	1.221	0.98
44_L	48_E	1.193	0.98
58_N	92_A	1.189	0.98
14_K	17_D	1.18	0.98
53_Y	64_E	1.179	0.98
133_I	140_F	1.177	0.98
118_V	122_G	1.175	0.98
40_N	63_G	1.148	0.97
142_F	147_L	1.141	0.97
27_F	33_A	1.094	0.96
105_T	145_H	1.089	0.96
70_T	80_E	1.077	0.95
53_Y	85_A	1.074	0.95
140_F	147_L	1.071	0.95
70_T	77_H	1.066	0.95
42_A	135_G	1.053	0.95
27_F	32_A	1.049	0.94
11_R	14_K	1.047	0.94
8_L	16_L	1.034	0.94
46_R	64_E	1.031	0.94
132_L	139_V	1.03	0.94
120_A	124_V	1.022	0.93
58_N	129_P	1.009	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
2qlcA	8	0.8514	100	0.149	Contact Map	0.845
1oi0A	4	0.7365	83.4	0.904	Contact Map	0.391
3k13A	3	0.9865	82.5	0.905	Contact Map	0.356
2kcqA	1	0.7635	80.7	0.906	Contact Map	0.36
4f7oA	2	0.9595	72	0.913	Contact Map	0.258
2kksA	1	0.7568	71	0.914	Contact Map	0.209
1jvnA	2	0.9189	70.7	0.914	Contact Map	0.205
3oqpA	2	0.6622	63.8	0.918	Contact Map	0.059
4cczA	1	0.9865	50.4	0.924	Contact Map	0.212
4h17A	2	0.7635	48.1	0.925	Contact Map	0.061

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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