May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YEDK - Uncharacterized protein YedK
UniProt: P76318 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13278
Length: 222 (220)
Sequences: 1245
Seq/Len: 5.66
YEDK
Paralog alert: 0.15 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
131_I 146_L 3.943 1.00
46_L 59_V 3.861 1.00
81_A 148_V 3.777 1.00
44_V 145_F 3.257 1.00
100_A 128_M 3.082 1.00
35_R 214_Q 2.928 1.00
97_I 172_A 2.853 1.00
78_V 148_V 2.837 1.00
18_L 127_F 2.794 1.00
96_A 130_A 2.618 1.00
114_Q 203_P 2.528 1.00
85_R 88_K 2.525 1.00
207_A 215_G 2.291 1.00
102_G 117_F 2.202 1.00
128_M 147_I 2.197 1.00
38_V 44_V 2.195 1.00
90_L 133_S 2.179 1.00
119_Y 200_S 2.093 1.00
168_S 171_A 2.006 1.00
7_Q 38_V 1.92 1.00
205_S 209_G 1.907 1.00
118_I 156_L 1.897 1.00
98_C 145_F 1.834 1.00
105_E 160_H 1.795 1.00
120_R 124_Q 1.771 1.00
118_I 159_I 1.756 1.00
73_L 86_M 1.746 1.00
126_I 199_F 1.684 1.00
103_W 153_D 1.642 1.00
5_F 44_V 1.614 0.99
153_D 163_R 1.61 0.99
119_Y 202_H 1.584 0.99
94_G 133_S 1.556 0.99
106_W 113_K 1.552 0.99
64_A 142_A 1.547 0.99
213_N 218_L 1.527 0.99
75_N 160_H 1.522 0.99
9_Q 101_D 1.488 0.99
17_L 172_A 1.466 0.99
194_V 199_F 1.458 0.99
171_A 174_E 1.435 0.98
97_I 127_F 1.427 0.98
76_A 146_L 1.42 0.98
148_V 189_A 1.372 0.98
54_L 173_R 1.359 0.97
37_N 106_W 1.358 0.97
151_A 161_D 1.355 0.97
166_V 199_F 1.333 0.97
46_L 145_F 1.319 0.97
134_T 143_E 1.316 0.97
96_A 132_G 1.302 0.96
48_S 57_D 1.296 0.96
116_F 203_P 1.291 0.96
63_Y 144_G 1.281 0.96
208_V 213_N 1.276 0.96
207_A 218_L 1.265 0.96
4_R 37_N 1.263 0.96
78_V 189_A 1.262 0.96
63_Y 133_S 1.261 0.96
2_C 160_H 1.25 0.95
82_A 91_W 1.25 0.95
1_M 4_R 1.235 0.95
46_L 98_C 1.23 0.95
79_E 162_R 1.215 0.94
98_C 147_I 1.205 0.94
81_A 91_W 1.193 0.93
81_A 189_A 1.192 0.93
10_T 13_D 1.186 0.93
155_G 197_N 1.174 0.93
44_V 98_C 1.17 0.93
109_E 112_K 1.17 0.93
80_T 84_S 1.14 0.91
117_F 202_H 1.112 0.90
120_R 123_G 1.111 0.90
196_A 199_F 1.108 0.90
4_R 40_P 1.104 0.89
67_W 70_K 1.103 0.89
37_N 115_P 1.103 0.89
6_A 117_F 1.094 0.89
155_G 158_D 1.078 0.88
98_C 130_A 1.077 0.88
207_A 217_E 1.073 0.88
130_A 146_L 1.071 0.87
121_A 200_S 1.068 0.87
154_Q 157_V 1.066 0.87
3_G 74_I 1.053 0.86
35_R 42_T 1.044 0.86
3_G 40_P 1.041 0.85
46_L 96_A 1.022 0.84
41_G 60_F 1.017 0.84
84_S 87_F 1.017 0.84
153_D 191_S 1.016 0.83
4_R 106_W 1.013 0.83
215_G 218_L 1.012 0.83
81_A 131_I 1.007 0.83
66_G 69_D 1.006 0.83
73_L 87_F 1.004 0.82
59_V 96_A 1.001 0.82
45_L 56_L 1.001 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2icuA20.9911000.029Contact Map0.764
2bdvA10.96851000.061Contact Map0.668
2f20A20.97751000.071Contact Map0.798
2aegA30.95051000.12Contact Map0.569
1zn6A10.90541000.152Contact Map0.741
2gs0B10.243211.30.96Contact Map0.948
2b3gB10.12615.40.966Contact Map0.877
2l14B10.22073.80.968Contact Map0.308
1a6sA10.30633.30.969Contact Map0.09
3bsuA60.238730.97Contact Map0.449
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0132 seconds.