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YDIY - Uncharacterized protein YdiY
UniProt: P76206 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13984
Length: 252 (235)
Sequences: 320
Seq/Len: 1.36

YDIY
Paralog alert: 0.07 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
191_T 209_A 2.824 1.00
223_A 245_T 2.444 1.00
150_F 178_G 2.241 0.99
141_Q 151_R 2.047 0.98
192_Q 208_S 1.949 0.97
148_H 180_Y 1.902 0.96
143_L 148_H 1.822 0.95
226_V 242_R 1.792 0.95
222_V 246_L 1.742 0.93
226_V 240_T 1.716 0.93
57_N 241_D 1.689 0.92
221_K 249_G 1.682 0.92
148_H 182_W 1.675 0.91
192_Q 206_S 1.662 0.91
113_Y 139_G 1.633 0.90
213_A 219_G 1.631 0.90
72_Y 105_R 1.592 0.88
19_A 22_N 1.579 0.88
96_E 124_R 1.534 0.86
48_N 249_G 1.501 0.84
50_G 106_F 1.5 0.84
113_Y 153_E 1.479 0.83
21_L 24_A 1.476 0.83
178_G 206_S 1.438 0.81
131_R 232_P 1.376 0.76
19_A 24_A 1.373 0.76
72_Y 107_N 1.361 0.75
48_N 221_K 1.36 0.75
22_N 28_S 1.329 0.73
18_F 23_A 1.325 0.72
190_F 208_S 1.324 0.72
185_T 188_A 1.32 0.72
128_Y 159_R 1.315 0.72
158_V 170_T 1.306 0.71
38_S 236_A 1.303 0.71
19_A 29_V 1.3 0.70
103_R 107_N 1.296 0.70
54_Q 60_S 1.275 0.68
19_A 28_S 1.265 0.67
93_R 96_E 1.258 0.67
28_S 33_M 1.254 0.66
29_V 33_M 1.244 0.65
204_L 228_W 1.238 0.65
26_D 31_T 1.238 0.65
21_L 27_D 1.227 0.64
50_G 64_T 1.226 0.64
22_N 33_M 1.225 0.64
20_S 34_D 1.221 0.63
127_G 233_P 1.216 0.63
196_V 202_T 1.215 0.63
128_Y 209_A 1.21 0.62
28_S 32_V 1.206 0.62
21_L 31_T 1.205 0.62
126_N 232_P 1.203 0.62
26_D 29_V 1.199 0.61
50_G 118_A 1.197 0.61
103_R 153_E 1.196 0.61
79_S 82_G 1.194 0.61
17_M 22_N 1.189 0.60
22_N 27_D 1.186 0.60
120_W 130_E 1.174 0.59
46_N 162_K 1.173 0.59
18_F 24_A 1.166 0.58
133_V 156_P 1.153 0.57
23_A 28_S 1.146 0.56
97_K 227_T 1.145 0.56
17_M 24_A 1.14 0.55
71_W 127_G 1.14 0.55
23_A 31_T 1.14 0.55
31_T 36_P 1.134 0.55
142_F 217_H 1.134 0.55
58_T 189_K 1.126 0.54
98_Y 123_D 1.126 0.54
80_L 102_G 1.124 0.54
48_N 66_D 1.123 0.54
17_M 23_A 1.123 0.54
26_D 30_F 1.118 0.53
207_E 223_A 1.114 0.53
156_P 202_T 1.103 0.52
55_S 61_S 1.103 0.52
113_Y 140_R 1.102 0.52
179_A 209_A 1.099 0.51
28_S 31_T 1.096 0.51
23_A 32_V 1.095 0.51
24_A 30_F 1.09 0.50
64_T 247_S 1.088 0.50
21_L 28_S 1.08 0.49
22_N 32_V 1.079 0.49
22_N 25_A 1.076 0.49
22_N 29_V 1.072 0.49
118_A 210_L 1.071 0.49
153_E 175_Y 1.071 0.49
63_L 108_L 1.07 0.48
180_Y 208_S 1.068 0.48
211_N 219_G 1.066 0.48
23_A 34_D 1.066 0.48
20_S 26_D 1.066 0.48
160_Y 168_S 1.065 0.48
84_A 98_Y 1.064 0.48
120_W 132_D 1.064 0.48
21_L 32_V 1.054 0.47
23_A 33_M 1.051 0.47
139_G 153_E 1.051 0.47
24_A 29_V 1.05 0.46
157_G 173_L 1.045 0.46
20_S 27_D 1.045 0.46
93_R 98_Y 1.043 0.46
57_N 158_V 1.032 0.45
143_L 180_Y 1.031 0.45
26_D 32_V 1.029 0.44
20_S 32_V 1.025 0.44
133_V 209_A 1.021 0.44
138_Y 188_A 1.019 0.43
27_D 32_V 1.018 0.43
29_V 32_V 1.017 0.43
135_T 194_V 1.016 0.43
18_F 21_L 1.016 0.43
71_W 77_A 1.014 0.43
66_D 95_S 1.012 0.43
100_A 134_L 1.012 0.43
17_M 21_L 1.008 0.42
23_A 90_N 1.008 0.42
150_F 180_Y 1.007 0.42
158_V 187_N 1.005 0.42
229_N 240_T 1.004 0.42
56_G 241_D 1.004 0.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3nb3A30.797697.60.872Contact Map0.28
2k0lA10.718393.40.91Contact Map0.458
2lhfA10.591392.50.912Contact Map0.51
3qraA10.543791.30.915Contact Map0.519
1p4tA10.607191.10.916Contact Map0.604
2x9kA10.686590.40.917Contact Map0.5
3kvnX20.960389.50.918Contact Map0.524
2jmmA10.575488.60.92Contact Map0.464
2x27X10.718388.10.92Contact Map0.46
1i78A20.841386.30.923Contact Map0.418

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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