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OPENSEQ.org

PTQA - N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIA component
UniProt: P69791 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10142
Length: 116 (103)
Sequences: 703
Seq/Len: 6.83

PTQA
Paralog alert: 0.47 [within 20: 0.06] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
51_K 112_E 4.319 1.00
41_Q 46_D 3.199 1.00
46_D 49_A 2.991 1.00
35_A 57_S 2.703 1.00
43_K 109_E 2.673 1.00
43_K 106_E 2.658 1.00
74_G 79_G 2.29 1.00
27_N 60_A 2.221 1.00
107_L 110_L 2.118 1.00
41_Q 53_M 2.093 1.00
68_Q 91_Q 2.012 1.00
39_L 104_I 1.989 1.00
41_Q 49_A 1.674 1.00
34_L 56_Q 1.674 1.00
52_A 56_Q 1.658 1.00
75_D 78_E 1.617 1.00
37_A 53_M 1.613 1.00
22_M 26_I 1.59 1.00
54_M 108_I 1.578 1.00
49_A 53_M 1.567 1.00
55_D 59_M 1.54 0.99
34_L 53_M 1.525 0.99
49_A 52_A 1.491 0.99
52_A 55_D 1.463 0.99
69_T 91_Q 1.431 0.99
30_Q 60_A 1.404 0.99
21_V 87_L 1.388 0.99
58_R 101_R 1.361 0.98
56_Q 59_M 1.311 0.98
53_M 56_Q 1.3 0.98
63_E 66_L 1.299 0.98
71_L 87_L 1.285 0.97
83_V 88_V 1.281 0.97
36_Y 100_A 1.263 0.97
42_A 108_I 1.24 0.96
93_H 102_E 1.188 0.95
73_E 77_G 1.145 0.94
41_Q 44_Q 1.109 0.92
28_S 64_A 1.109 0.92
59_M 63_E 1.098 0.92
26_I 30_Q 1.07 0.91
55_D 58_R 1.064 0.90
68_Q 96_T 1.052 0.90
58_R 105_T 1.04 0.89
39_L 103_L 1.037 0.89
91_Q 96_T 1.028 0.88
40_K 106_E 1.026 0.88
51_K 55_D 1.026 0.88
39_L 107_L 1.02 0.88
74_G 77_G 1.014 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1wcrA30.88791000.142Contact Map0.611
2e2aA30.90521000.143Contact Map0.807
3k1sA90.91381000.144Contact Map0.847
3l8rA80.98281000.148Contact Map0.845
3qwwA10.706910.50.934Contact Map0.625
4i2zA10.5699.80.935Contact Map0.686
2zanA10.75865.90.941Contact Map
3bu8A20.87074.30.945Contact Map0.458
3ro2A10.53453.80.946Contact Map0.751
1wao140.70693.70.946Contact Map0.843

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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