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YFGC - TPR repeat-containing protein YfgC
UniProt: P66948 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14199
Length: 487 (470)
Sequences: 544
Seq/Len: 1.16
YFGC
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
125_D 228_K 3.378 1.00
324_K 327_E 2.8 1.00
358_K 361_E 2.704 1.00
116_L 134_M 2.611 1.00
194_I 197_T 2.544 1.00
80_G 96_F 2.432 0.99
129_Q 224_T 2.295 0.99
363_I 382_L 2.146 0.98
382_L 386_Y 2.103 0.98
354_L 385_A 2.096 0.98
163_G 185_T 2.096 0.98
396_A 420_E 2.066 0.97
391_Q 394_E 2.064 0.97
223_P 256_A 2.007 0.97
425_N 428_Q 1.944 0.96
239_P 244_L 1.936 0.96
129_Q 228_K 1.932 0.96
297_L 301_A 1.923 0.95
241_E 251_S 1.919 0.95
124_S 130_L 1.908 0.95
167_S 178_G 1.908 0.95
132_S 221_A 1.903 0.95
125_D 278_K 1.859 0.94
319_A 327_E 1.79 0.93
103_E 117_H 1.747 0.91
274_F 278_K 1.721 0.91
413_W 432_A 1.72 0.91
34_P 37_G 1.717 0.91
367_K 394_E 1.709 0.90
353_D 361_E 1.7 0.90
435_E 470_R 1.683 0.89
174_S 179_M 1.603 0.86
366_L 381_N 1.601 0.86
329_R 349_A 1.558 0.84
292_L 296_L 1.555 0.84
101_N 117_H 1.521 0.82
396_A 416_L 1.487 0.80
461_S 465_A 1.473 0.79
83_L 138_I 1.463 0.78
79_L 217_F 1.463 0.78
331_T 335_L 1.462 0.78
339_E 342_N 1.457 0.78
190_R 193_M 1.447 0.77
22_V 28_D 1.43 0.76
363_I 389_G 1.424 0.75
5_L 24_P 1.42 0.75
167_S 182_L 1.418 0.75
12_T 15_A 1.415 0.75
430_L 449_L 1.397 0.73
316_A 419_A 1.396 0.73
71_L 280_R 1.387 0.73
319_A 324_K 1.374 0.72
363_I 385_A 1.368 0.71
431_A 467_Y 1.365 0.71
434_A 450_L 1.365 0.71
199_Q 202_Q 1.365 0.71
124_S 274_F 1.362 0.71
117_H 245_T 1.354 0.70
202_Q 251_S 1.337 0.69
403_T 413_W 1.324 0.68
191_Q 195_S 1.315 0.67
309_R 345_Y 1.314 0.67
289_R 293_T 1.313 0.67
56_Y 109_F 1.311 0.67
80_G 94_F 1.311 0.67
6_K 24_P 1.305 0.66
104_I 225_F 1.304 0.66
475_R 478_Q 1.297 0.65
50_M 54_D 1.297 0.65
5_L 27_A 1.296 0.65
212_L 324_K 1.294 0.65
274_F 277_A 1.292 0.65
197_T 202_Q 1.288 0.65
227_E 257_R 1.282 0.64
7_K 15_A 1.28 0.64
12_T 21_Q 1.28 0.64
76_I 178_G 1.28 0.64
206_R 255_D 1.276 0.63
312_Q 334_P 1.268 0.63
353_D 365_R 1.267 0.63
333_Q 349_A 1.264 0.62
226_L 253_L 1.254 0.61
19_I 22_V 1.248 0.61
12_T 24_P 1.245 0.61
18_T 21_Q 1.245 0.61
386_Y 394_E 1.239 0.60
5_L 22_V 1.231 0.59
272_E 276_L 1.228 0.59
80_G 138_I 1.227 0.59
221_A 226_L 1.224 0.59
84_V 114_V 1.222 0.59
6_K 23_A 1.221 0.58
104_I 245_T 1.22 0.58
292_L 297_L 1.218 0.58
108_A 112_G 1.212 0.58
208_G 215_S 1.208 0.57
396_A 419_A 1.204 0.57
15_A 19_I 1.201 0.57
6_K 12_T 1.195 0.56
6_K 9_L 1.192 0.56
301_A 306_R 1.192 0.56
367_K 382_L 1.19 0.55
5_L 8_N 1.188 0.55
15_A 22_V 1.187 0.55
312_Q 331_T 1.186 0.55
15_A 24_P 1.183 0.55
100_N 215_S 1.176 0.54
96_F 191_Q 1.174 0.54
14_I 18_T 1.173 0.54
72_L 98_L 1.172 0.54
21_Q 24_P 1.166 0.53
76_I 96_F 1.164 0.53
208_G 259_R 1.162 0.53
280_R 366_L 1.162 0.53
121_F 185_T 1.16 0.53
9_L 18_T 1.155 0.52
75_Y 112_G 1.151 0.52
349_A 353_D 1.149 0.52
163_G 190_R 1.148 0.51
157_A 168_I 1.146 0.51
131_A 217_F 1.143 0.51
364_N 390_G 1.14 0.51
316_A 424_N 1.139 0.51
19_I 27_A 1.139 0.51
72_L 277_A 1.137 0.50
312_Q 335_L 1.136 0.50
336_L 346_L 1.134 0.50
344_W 347_D 1.134 0.50
433_R 437_Y 1.129 0.50
52_M 196_F 1.128 0.50
7_K 18_T 1.128 0.50
191_Q 335_L 1.128 0.50
125_D 129_Q 1.123 0.49
223_P 255_D 1.123 0.49
80_G 97_F 1.122 0.49
8_N 23_A 1.121 0.49
162_V 170_L 1.119 0.49
75_Y 127_E 1.116 0.48
302_K 306_R 1.114 0.48
9_L 24_P 1.112 0.48
24_P 27_A 1.112 0.48
5_L 28_D 1.11 0.48
228_K 278_K 1.11 0.48
49_E 144_R 1.109 0.48
329_R 356_Q 1.109 0.48
326_D 358_K 1.107 0.48
326_D 333_Q 1.107 0.48
225_F 229_L 1.104 0.47
21_Q 28_D 1.102 0.47
15_A 18_T 1.101 0.47
234_R 243_L 1.1 0.47
329_R 353_D 1.099 0.47
108_A 115_V 1.099 0.47
19_I 23_A 1.099 0.47
129_Q 388_Q 1.095 0.46
134_M 258_N 1.095 0.46
8_N 18_T 1.093 0.46
109_F 147_A 1.092 0.46
311_A 382_L 1.09 0.46
278_K 424_N 1.089 0.46
9_L 28_D 1.088 0.46
6_K 18_T 1.084 0.45
316_A 332_L 1.084 0.45
18_T 22_V 1.084 0.45
214_R 336_L 1.081 0.45
209_I 264_R 1.079 0.45
264_R 369_A 1.075 0.44
224_T 227_E 1.073 0.44
146_L 187_A 1.073 0.44
245_T 274_F 1.072 0.44
94_F 142_T 1.07 0.44
197_T 200_N 1.068 0.44
12_T 19_I 1.066 0.44
310_A 314_G 1.064 0.43
333_Q 337_A 1.063 0.43
464_Q 468_D 1.06 0.43
454_S 468_D 1.059 0.43
116_L 238_R 1.059 0.43
245_T 319_A 1.058 0.43
129_Q 226_L 1.058 0.43
22_V 27_A 1.058 0.43
437_Y 442_R 1.057 0.43
187_A 206_R 1.054 0.42
24_P 28_D 1.054 0.42
296_L 301_A 1.052 0.42
435_E 439_L 1.051 0.42
19_I 28_D 1.049 0.42
213_Q 260_A 1.049 0.42
96_F 138_I 1.048 0.42
121_F 277_A 1.046 0.42
9_L 21_Q 1.043 0.41
18_T 23_A 1.043 0.41
8_N 19_I 1.042 0.41
399_L 416_L 1.042 0.41
67_I 336_L 1.039 0.41
6_K 21_Q 1.039 0.41
393_Q 425_N 1.039 0.41
104_I 257_R 1.038 0.41
222_M 260_A 1.036 0.41
253_L 261_N 1.035 0.41
325_Y 356_Q 1.034 0.41
456_Q 465_A 1.03 0.40
8_N 13_L 1.029 0.40
164_A 186_L 1.029 0.40
33_L 36_M 1.027 0.40
367_K 371_D 1.026 0.40
281_T 343_A 1.023 0.40
195_S 226_L 1.023 0.40
139_S 142_T 1.022 0.39
7_K 22_V 1.022 0.39
177_A 181_A 1.02 0.39
9_L 12_T 1.017 0.39
7_K 23_A 1.017 0.39
143_Q 259_R 1.016 0.39
53_G 61_R 1.015 0.39
149_A 196_F 1.015 0.39
167_S 236_S 1.015 0.39
85_S 174_S 1.014 0.39
8_N 24_P 1.014 0.39
6_K 22_V 1.011 0.38
33_L 37_G 1.011 0.38
8_N 28_D 1.009 0.38
447_I 474_L 1.008 0.38
198_Q 317_L 1.008 0.38
14_I 21_Q 1.005 0.38
403_T 416_L 1.004 0.38
110_F 203_E 1 0.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c37A20.51131000.655Contact Map0.544
4aw6A40.51131000.799Contact Map0.451
4il3A20.52161000.804Contact Map0.427
3urzA20.355299.70.868Contact Map0.595
4gywA20.38499.70.875Contact Map0.772
3cqbA20.207499.70.875Contact Map0.55
1w3bA20.433399.70.876Contact Map0.718
4kvmA40.455999.60.879Contact Map0.749
3dssA10.525799.60.88Contact Map0.612
3q7aA10.542199.60.88Contact Map0.466
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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