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OPENSEQ.org

QUED - 6-carboxy-5,6,7,8-tetrahydropterin synthase
UniProt: P65870 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13120
Length: 121 (120)
Sequences: 1453
Seq/Len: 12.11

QUED
Paralog alert: 0.13 [within 20: 0.03] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
13_E 34_S 3.892 1.00
107_M 117_I 2.78 1.00
68_R 95_Q 2.519 1.00
90_K 94_D 2.474 1.00
105_A 117_I 2.394 1.00
105_A 119_R 2.313 1.00
43_G 52_I 2.234 1.00
41_I 58_L 2.222 1.00
9_D 36_M 2.22 1.00
9_D 38_R 2.161 1.00
17_R 73_Y 2.139 1.00
7_F 40_E 2.066 1.00
69_L 91_W 2.057 1.00
5_T 42_T 1.889 1.00
12_F 37_V 1.841 1.00
7_F 115_G 1.802 1.00
75_N 83_P 1.793 1.00
30_L 73_Y 1.785 1.00
38_R 107_M 1.782 1.00
93_W 120_G 1.768 1.00
37_V 108_V 1.744 1.00
39_L 62_F 1.744 1.00
42_T 104_S 1.667 1.00
63_K 67_E 1.66 1.00
5_T 40_E 1.613 1.00
64_P 99_V 1.612 1.00
97_K 120_G 1.548 1.00
69_L 92_I 1.541 1.00
38_R 109_K 1.492 1.00
41_I 53_I 1.415 1.00
90_K 118_Y 1.361 0.99
40_E 105_A 1.353 0.99
39_L 96_V 1.295 0.99
69_L 95_Q 1.275 0.99
15_A 73_Y 1.269 0.99
8_K 113_T 1.269 0.99
89_A 106_V 1.248 0.99
34_S 112_C 1.232 0.98
27_C 71_H 1.227 0.98
60_A 64_P 1.215 0.98
7_F 38_R 1.199 0.98
29_R 72_H 1.19 0.98
95_Q 98_P 1.173 0.98
7_F 107_M 1.156 0.97
91_W 95_Q 1.122 0.97
93_W 118_Y 1.115 0.96
50_G 87_V 1.11 0.96
37_V 62_F 1.095 0.96
10_F 59_K 1.066 0.95
54_D 57_E 1.05 0.94
19_P 28_G 1.049 0.94
28_G 84_T 1.032 0.94
107_M 115_G 1.017 0.93
89_A 116_C 1.016 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2obaA611000.074Contact Map0.868
3d7jA60.99171000.098Contact Map0.824
2g64A111000.132Contact Map0.795
1b66A211000.133Contact Map0.774
3jygA60.96691000.15Contact Map0.788
2dj6A30.92561000.174Contact Map0.803
1y13A30.96691000.183Contact Map0.677
3lx3A10.96691000.195Contact Map0.709
3o1kA40.851239.70.917Contact Map0.766
1dhnA10.859529.20.923Contact Map0.659

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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