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YFCD - Uncharacterized Nudix hydrolase YfcD
UniProt: P65556 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14107
Length: 180 (162)
Sequences: 1064
Seq/Len: 6.57

YFCD
Paralog alert: 0.42 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: IDI YFCD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
16_N 20_E 6.294 1.00
46_D 50_K 5.461 1.00
58_E 65_G 3.975 1.00
47_G 125_H 3.963 1.00
55_R 137_E 3.18 1.00
141_L 146_I 2.946 1.00
58_E 136_S 2.707 1.00
19_N 38_R 2.449 1.00
55_R 136_S 2.264 1.00
42_I 85_A 2.216 1.00
45_H 51_I 2.146 1.00
71_A 89_A 2.058 1.00
31_R 115_V 1.881 1.00
88_E 91_E 1.828 1.00
90_E 96_A 1.827 1.00
52_L 138_V 1.817 1.00
74_V 115_V 1.749 1.00
128_F 138_V 1.729 1.00
29_Q 33_Q 1.725 1.00
31_R 74_V 1.697 1.00
15_V 38_R 1.67 1.00
67_L 139_C 1.658 1.00
80_Q 83_E 1.646 1.00
69_A 72_G 1.515 0.99
63_L 155_P 1.451 0.99
104_G 119_L 1.45 0.99
55_R 65_G 1.431 0.99
42_I 89_A 1.403 0.99
24_Q 77_A 1.402 0.99
65_G 136_S 1.398 0.99
95_I 124_S 1.377 0.98
49_G 123_V 1.367 0.98
142_T 145_E 1.344 0.98
93_L 138_V 1.326 0.98
68_D 72_G 1.296 0.97
149_R 153_F 1.296 0.97
39_A 108_F 1.295 0.97
52_L 140_W 1.294 0.97
26_S 29_Q 1.29 0.97
93_L 135_V 1.266 0.97
49_G 78_D 1.262 0.97
84_S 87_R 1.24 0.96
81_L 118_A 1.228 0.96
145_E 148_A 1.227 0.96
79_E 87_R 1.219 0.96
25_A 30_M 1.21 0.95
142_T 146_I 1.202 0.95
146_I 157_S 1.199 0.95
27_R 88_E 1.193 0.95
130_L 138_V 1.183 0.95
40_T 84_S 1.139 0.93
30_M 74_V 1.098 0.91
41_Y 72_G 1.094 0.91
11_W 24_Q 1.092 0.91
129_A 148_A 1.091 0.91
41_Y 69_A 1.075 0.90
44_V 95_I 1.059 0.89
50_K 142_T 1.043 0.88
50_K 145_E 1.033 0.88
41_Y 68_D 1.025 0.87
31_R 37_H 1.025 0.87
75_V 88_E 1.019 0.87
130_L 135_V 1.015 0.86
10_E 64_P 1.015 0.86
66_M 154_T 1.011 0.86
105_Q 118_A 1.002 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2dhoA111000.383Contact Map0.834
2pnyA111000.387Contact Map0.844
2fkbA311000.443Contact Map0.709
1hztA10.951000.477Contact Map0.793
3dupA20.98891000.482Contact Map0.628
1q27A10.92221000.504Contact Map0.365
2xsqA10.961199.80.619Contact Map0.418
3e57A20.911199.80.625Contact Map0.452
1sjyA10.827899.80.644Contact Map0.632
3q91A40.927899.80.653Contact Map0.551

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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