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OPENSEQ.org

UPPP - Undecaprenyl-diphosphatase
UniProt: P60932 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11665
Length: 273 (267)
Sequences: 1840
Seq/Len: 6.89

UPPP
Paralog alert: 0.10 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
67_R 194_E 3.449 1.00
16_V 34_V 3.184 1.00
163_F 181_G 3.064 1.00
98_G 195_F 2.899 1.00
103_V 206_G 2.875 1.00
127_V 265_A 2.674 1.00
17_E 56_S 2.596 1.00
182_G 187_V 2.532 1.00
68_L 201_V 2.455 1.00
114_K 211_D 2.434 1.00
99_M 203_M 2.428 1.00
131_L 135_A 2.346 1.00
11_A 233_T 2.332 1.00
102_A 203_M 2.313 1.00
188_S 191_A 2.241 1.00
124_Y 128_V 2.08 1.00
10_A 14_G 2.058 1.00
138_C 255_I 1.991 1.00
247_Q 251_R 1.978 1.00
158_F 162_C 1.922 1.00
206_G 210_L 1.906 1.00
209_A 213_Y 1.903 1.00
130_G 262_F 1.862 1.00
6_S 9_I 1.846 1.00
247_Q 250_K 1.792 1.00
56_S 238_A 1.785 1.00
259_I 263_I 1.763 1.00
60_V 242_I 1.763 1.00
31_M 49_E 1.73 1.00
65_W 69_F 1.712 1.00
14_G 233_T 1.701 1.00
15_V 237_V 1.693 1.00
109_F 112_T 1.69 1.00
118_N 121_N 1.673 1.00
233_T 237_V 1.668 1.00
155_R 159_M 1.652 1.00
7_L 229_V 1.648 1.00
102_A 165_C 1.632 1.00
96_L 100_I 1.596 1.00
99_M 103_V 1.585 1.00
13_L 31_M 1.572 1.00
29_G 122_V 1.569 1.00
236_V 240_I 1.552 0.99
248_L 252_I 1.544 0.99
13_L 34_V 1.538 0.99
134_I 255_I 1.527 0.99
110_H 211_D 1.502 0.99
265_A 269_Y 1.497 0.99
123_M 265_A 1.486 0.99
105_L 165_C 1.465 0.99
245_F 252_I 1.465 0.99
98_G 199_L 1.459 0.99
210_L 214_K 1.456 0.99
63_M 243_K 1.455 0.99
110_H 114_K 1.448 0.99
33_I 268_V 1.44 0.99
90_L 94_H 1.437 0.99
190_Y 250_K 1.407 0.99
62_V 235_F 1.405 0.99
113_I 168_L 1.398 0.99
125_A 128_V 1.394 0.99
53_Q 204_M 1.379 0.99
47_T 51_V 1.372 0.98
11_A 15_V 1.363 0.98
97_L 154_Y 1.358 0.98
133_L 137_E 1.343 0.98
193_S 246_L 1.323 0.98
159_M 185_M 1.314 0.98
235_F 239_L 1.311 0.98
210_L 213_Y 1.305 0.98
193_S 249_I 1.28 0.97
10_A 229_V 1.279 0.97
266_A 270_V 1.271 0.97
12_I 16_V 1.253 0.97
103_V 107_L 1.253 0.97
162_C 166_L 1.243 0.97
25_V 245_F 1.24 0.97
57_I 200_A 1.235 0.96
112_T 115_S 1.233 0.96
153_T 156_Q 1.226 0.96
70_G 88_G 1.221 0.96
68_L 72_I 1.212 0.96
248_L 256_P 1.208 0.96
22_F 238_A 1.208 0.96
232_I 236_V 1.203 0.96
32_I 122_V 1.173 0.95
102_A 168_L 1.173 0.95
148_G 151_D 1.168 0.95
54_L 204_M 1.165 0.95
120_I 269_Y 1.161 0.94
10_A 48_F 1.152 0.94
7_L 11_A 1.146 0.94
129_G 261_R 1.146 0.94
147_P 156_Q 1.145 0.94
58_L 235_F 1.137 0.94
229_V 233_T 1.136 0.94
176_G 183_M 1.126 0.93
237_V 241_A 1.125 0.93
156_Q 185_M 1.113 0.93
228_A 232_I 1.111 0.93
206_G 209_A 1.11 0.93
64_F 246_L 1.108 0.93
154_Y 158_F 1.1 0.92
125_A 169_W 1.093 0.92
172_F 177_A 1.089 0.92
137_E 253_S 1.088 0.92
19_L 25_V 1.084 0.91
50_V 211_D 1.079 0.91
53_Q 56_S 1.078 0.91
105_L 109_F 1.072 0.91
91_T 198_L 1.067 0.91
205_M 209_A 1.066 0.90
28_T 57_I 1.066 0.90
103_V 106_G 1.06 0.90
30_H 260_Y 1.056 0.90
46_K 53_Q 1.049 0.90
137_E 189_R 1.037 0.89
90_L 93_I 1.034 0.89
255_I 259_I 1.034 0.89
97_L 158_F 1.033 0.89
52_I 230_G 1.029 0.88
132_L 180_S 1.019 0.88
28_T 53_Q 1.015 0.87
11_A 229_V 1.013 0.87
105_L 168_L 1.008 0.87
156_Q 182_G 1.007 0.87
190_Y 194_E 1.002 0.86
50_V 207_A 1 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
2wwbB10.24544.90.972Contact Map0.257
3ux4A30.40293.70.974Contact Map0.289
3mp7B10.21982.80.975Contact Map0.304
1fdmA10.16122.20.977Contact Map0.439
1ifkA10.16481.90.977Contact Map0.353
1jb0M10.11361.90.978Contact Map0.273
1iflA10.19411.60.978Contact Map0.343
2ww9B10.28941.60.978Contact Map0.316
1q90G10.13551.40.979Contact Map0.367
4h44G10.13551.30.979Contact Map0.684

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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