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OPENSEQ.org
CAIA - Crotonobetainyl-CoA dehydrogenase
UniProt: P60584 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11560
Length: 380 (377)
Sequences: 15492
Seq/Len: 41.09
CAIA
Paralog alert: 0.77 [within 20: 0.29] - ratio of genomes with paralogs
Cluster includes: CAIA YDIO
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
150_N 214_D 3.921 1.00
146_K 216_E 3.86 1.00
289_K 327_E 3.449 1.00
24_N 45_A 3.419 1.00
103_Q 107_D 3.31 1.00
112_F 117_K 3.079 1.00
31_E 35_D 2.98 1.00
142_R 219_E 2.954 1.00
193_K 213_D 2.935 1.00
143_R 216_E 2.721 1.00
261_R 265_Q 2.715 1.00
181_T 222_M 2.621 1.00
282_K 331_S 2.549 1.00
66_G 69_T 2.517 1.00
112_F 118_Q 2.51 1.00
18_E 76_E 2.48 1.00
263_A 335_V 2.34 1.00
225_R 228_N 2.279 1.00
19_L 23_E 2.189 1.00
103_Q 106_I 2.155 1.00
152_S 211_T 2.137 1.00
102_T 105_Q 2.081 1.00
228_N 231_N 2.072 1.00
272_A 275_R 2.07 1.00
253_M 294_K 2.064 1.00
57_P 98_L 2.022 1.00
343_G 348_S 1.936 1.00
44_K 48_D 1.92 1.00
302_W 306_N 1.913 1.00
169_A 183_W 1.913 1.00
45_A 48_D 1.891 1.00
148_Y 216_E 1.884 1.00
6_N 9_Q 1.857 1.00
143_R 146_K 1.853 1.00
142_R 226_E 1.849 1.00
267_V 272_A 1.788 1.00
256_F 290_L 1.774 1.00
107_D 111_A 1.755 1.00
10_E 14_A 1.732 1.00
75_M 294_K 1.695 1.00
76_E 79_R 1.694 1.00
218_D 221_D 1.69 1.00
147_I 219_E 1.69 1.00
189_K 215_V 1.679 1.00
143_R 148_Y 1.658 1.00
152_S 209_E 1.646 1.00
278_L 281_E 1.646 1.00
263_A 279_I 1.645 1.00
258_D 346_R 1.643 1.00
323_N 364_D 1.641 1.00
12_F 15_G 1.637 1.00
253_M 257_E 1.63 1.00
292_S 320_F 1.63 1.00
165_I 187_M 1.628 1.00
348_S 352_R 1.626 1.00
79_R 257_E 1.617 1.00
159_S 208_C 1.599 1.00
125_T 155_F 1.59 1.00
222_M 226_E 1.579 1.00
9_Q 69_T 1.572 1.00
108_K 220_K 1.567 1.00
145_G 219_E 1.562 1.00
149_L 183_W 1.539 1.00
271_E 275_R 1.537 1.00
15_G 19_L 1.535 1.00
147_I 183_W 1.534 1.00
40_E 44_K 1.528 1.00
293_M 321_C 1.525 1.00
121_N 165_I 1.52 1.00
108_K 112_F 1.513 1.00
112_F 115_T 1.511 1.00
279_I 335_V 1.494 1.00
150_N 213_D 1.492 1.00
319_Y 364_D 1.49 1.00
268_Q 276_F 1.484 1.00
12_F 16_I 1.48 1.00
339_V 345_H 1.48 1.00
145_G 216_E 1.48 1.00
258_D 261_R 1.474 1.00
148_Y 214_D 1.471 1.00
34_R 198_E 1.471 1.00
58_E 64_D 1.467 1.00
141_T 150_N 1.466 1.00
286_M 328_V 1.457 1.00
100_E 235_E 1.455 1.00
104_E 108_K 1.447 1.00
219_E 222_M 1.43 1.00
54_L 73_V 1.419 1.00
255_A 329_V 1.415 1.00
104_E 220_K 1.404 0.99
7_D 12_F 1.404 0.99
193_K 211_T 1.399 0.99
254_C 258_D 1.389 0.99
142_R 146_K 1.385 0.99
14_A 76_E 1.381 0.99
299_E 303_K 1.378 0.99
146_K 219_E 1.372 0.99
160_A 208_C 1.369 0.99
186_D 189_K 1.36 0.99
60_H 106_I 1.353 0.99
285_H 368_I 1.347 0.99
303_K 313_D 1.341 0.99
252_A 290_L 1.338 0.99
104_E 107_D 1.327 0.99
189_K 221_D 1.324 0.99
9_Q 66_G 1.313 0.99
195_T 211_T 1.303 0.99
327_E 331_S 1.302 0.99
192_I 210_I 1.292 0.99
330_D 358_R 1.289 0.99
186_D 221_D 1.288 0.99
198_E 343_G 1.287 0.99
217_L 221_D 1.283 0.99
44_K 117_K 1.281 0.99
293_M 324_A 1.281 0.99
291_N 299_E 1.28 0.99
147_I 226_E 1.275 0.99
113_R 120_W 1.272 0.99
111_A 115_T 1.268 0.99
32_C 204_M 1.251 0.99
17_R 51_I 1.251 0.99
332_A 347_I 1.246 0.98
149_L 167_V 1.242 0.98
195_T 209_E 1.242 0.98
65_A 69_T 1.24 0.98
28_Y 32_C 1.24 0.98
282_K 365_E 1.237 0.98
16_I 49_M 1.237 0.98
128_G 137_K 1.237 0.98
258_D 336_L 1.236 0.98
326_F 358_R 1.223 0.98
9_Q 72_A 1.222 0.98
28_Y 31_E 1.219 0.98
286_M 331_S 1.209 0.98
290_L 328_V 1.205 0.98
249_Y 290_L 1.204 0.98
45_A 49_M 1.202 0.98
252_A 328_V 1.2 0.98
79_R 253_M 1.194 0.98
187_M 192_I 1.192 0.98
256_F 260_A 1.19 0.98
10_E 15_G 1.189 0.98
299_E 302_W 1.186 0.98
21_A 80_L 1.184 0.98
172_G 175_P 1.184 0.98
47_A 52_D 1.177 0.98
142_R 147_I 1.17 0.97
254_C 350_F 1.169 0.97
230_F 234_K 1.169 0.97
303_K 308_T 1.169 0.97
101_G 105_Q 1.167 0.97
259_A 332_A 1.166 0.97
123_A 156_I 1.164 0.97
75_M 298_Y 1.153 0.97
56_I 114_G 1.151 0.97
59_E 107_D 1.147 0.97
315_A 367_Q 1.147 0.97
20_M 45_A 1.146 0.97
271_E 276_F 1.143 0.97
7_D 10_E 1.142 0.97
330_D 355_R 1.141 0.97
323_N 327_E 1.139 0.97
190_P 216_E 1.136 0.97
246_L 297_L 1.133 0.97
289_K 324_A 1.13 0.97
16_I 51_I 1.122 0.97
260_A 264_N 1.116 0.96
141_T 148_Y 1.112 0.96
139_T 150_N 1.105 0.96
138_T 149_L 1.103 0.96
68_V 302_W 1.1 0.96
288_I 316_M 1.098 0.96
44_K 47_A 1.093 0.96
18_E 22_S 1.084 0.96
140_Y 183_W 1.071 0.95
106_I 110_M 1.06 0.95
67_F 305_D 1.057 0.95
120_W 164_Y 1.051 0.94
165_I 192_I 1.051 0.94
17_R 21_A 1.05 0.94
326_F 330_D 1.046 0.94
187_M 194_V 1.045 0.94
167_V 185_V 1.04 0.94
238_D 311_S 1.038 0.94
287_A 291_N 1.036 0.94
105_Q 109_I 1.036 0.94
325_A 354_L 1.03 0.94
81_G 84_T 1.029 0.94
167_V 212_F 1.023 0.93
200_L 351_W 1.017 0.93
105_Q 184_F 1.016 0.93
191_G 215_V 1.016 0.93
30_A 34_R 1.008 0.93
240_E 361_G 1.004 0.93
20_M 49_M 1.003 0.93
355_R 358_R 1 0.92
75_M 253_M 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ktoA40.99741000.042Contact Map0.784
2d29A20.99471000.048Contact Map0.786
2jifA40.99211000.05Contact Map0.824
1ivhA40.99741000.052Contact Map0.809
1bucA20.98951000.053Contact Map0.827
4irnA80.98951000.053Contact Map0.848
1ukwA20.99211000.053Contact Map0.805
1egdA40.99741000.054Contact Map0.876
4iv6A20.99471000.056Contact Map0.785
3pfdA40.98951000.056Contact Map0.82
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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