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OPENSEQ.org
SCPC - Propionyl-CoA:succinate CoA transferase
UniProt: P52043 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12973
Length: 492 (485)
Sequences: 878
Seq/Len: 1.81
SCPC
Paralog alert: 0.14 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
280_P 302_S 4.156 1.00
297_E 318_K 3.386 1.00
317_R 321_D 3.202 1.00
11_N 43_R 2.823 1.00
428_Q 451_H 2.79 1.00
358_F 424_I 2.602 1.00
163_H 215_N 2.582 1.00
436_L 444_T 2.496 1.00
123_D 155_K 2.479 1.00
294_H 318_K 2.34 1.00
121_D 155_K 2.31 1.00
9_T 12_E 2.26 1.00
18_Q 21_D 2.256 1.00
483_N 487_T 2.255 1.00
129_A 138_V 2.19 0.99
246_A 348_G 2.115 0.99
129_A 159_I 2.065 0.99
140_L 201_V 2.051 0.99
356_L 375_M 2.015 0.99
23_V 57_I 1.965 0.98
358_F 407_V 1.961 0.98
141_T 165_H 1.953 0.98
133_A 137_R 1.949 0.98
464_N 476_H 1.938 0.98
284_Y 343_I 1.898 0.98
386_R 420_S 1.897 0.98
273_G 298_T 1.892 0.98
22_M 58_R 1.865 0.98
246_A 249_R 1.84 0.97
16_I 210_A 1.761 0.96
431_A 447_D 1.759 0.96
473_D 476_H 1.758 0.96
144_I 175_I 1.751 0.96
190_F 194_D 1.745 0.96
370_A 485_I 1.738 0.96
227_N 230_C 1.73 0.96
243_Q 247_H 1.724 0.96
442_A 446_I 1.71 0.96
232_Q 235_D 1.702 0.95
407_V 426_T 1.7 0.95
242_L 276_P 1.687 0.95
395_A 406_T 1.683 0.95
444_T 447_D 1.681 0.95
356_L 369_V 1.68 0.95
48_Q 53_K 1.679 0.95
443_R 459_H 1.663 0.95
228_P 231_Q 1.661 0.95
132_L 138_V 1.655 0.94
229_M 396_P 1.634 0.94
355_G 366_S 1.633 0.94
129_A 161_L 1.626 0.94
378_I 419_H 1.623 0.94
364_A 421_V 1.62 0.94
365_N 411_C 1.597 0.93
164_Y 217_P 1.596 0.93
422_K 432_D 1.549 0.91
397_S 451_H 1.542 0.91
148_P 152_L 1.541 0.91
234_A 238_V 1.538 0.91
25_F 38_P 1.53 0.91
14_A 44_R 1.53 0.91
159_I 208_I 1.519 0.90
156_K 210_A 1.513 0.90
160_E 214_T 1.509 0.90
45_A 78_A 1.499 0.90
425_I 431_A 1.498 0.89
9_T 13_A 1.495 0.89
220_G 317_R 1.493 0.89
12_E 15_E 1.49 0.89
191_H 194_D 1.483 0.89
17_I 41_I 1.471 0.88
398_I 454_Y 1.462 0.88
286_E 380_G 1.458 0.88
382_G 417_S 1.456 0.88
189_I 196_V 1.448 0.87
397_S 428_Q 1.448 0.87
355_G 364_A 1.44 0.87
142_S 165_H 1.436 0.87
319_I 323_M 1.434 0.87
286_E 339_N 1.428 0.86
189_I 343_I 1.424 0.86
447_D 455_R 1.422 0.86
10_A 40_A 1.415 0.86
163_H 213_E 1.404 0.85
457_Y 461_Y 1.401 0.85
357_E 412_S 1.392 0.84
428_Q 455_R 1.39 0.84
370_A 484_L 1.388 0.84
355_G 393_F 1.379 0.84
283_M 301_I 1.366 0.83
138_V 208_I 1.364 0.83
21_D 124_V 1.361 0.82
459_H 463_E 1.359 0.82
37_L 126_V 1.353 0.82
297_E 326_F 1.351 0.82
367_T 415_D 1.35 0.82
79_V 91_L 1.336 0.81
352_L 394_M 1.334 0.81
456_D 460_R 1.332 0.81
412_S 478_F 1.33 0.80
40_A 44_R 1.329 0.80
368_H 413_H 1.327 0.80
279_P 300_K 1.314 0.79
189_I 194_D 1.306 0.79
101_S 437_S 1.301 0.78
14_A 40_A 1.301 0.78
179_G 185_N 1.3 0.78
137_R 200_Y 1.298 0.78
287_V 309_L 1.292 0.78
479_D 483_N 1.29 0.77
8_M 210_A 1.288 0.77
127_I 151_L 1.285 0.77
365_N 368_H 1.28 0.77
138_V 159_I 1.279 0.77
230_C 396_P 1.277 0.76
447_D 459_H 1.274 0.76
482_R 486_A 1.274 0.76
249_R 348_G 1.274 0.76
476_H 479_D 1.26 0.75
43_R 46_N 1.259 0.75
342_E 346_R 1.259 0.75
355_G 395_A 1.257 0.75
160_E 216_L 1.251 0.74
424_I 445_I 1.245 0.74
208_I 211_V 1.243 0.74
232_Q 236_N 1.238 0.73
263_N 266_N 1.229 0.73
13_A 158_I 1.225 0.72
17_I 126_V 1.221 0.72
249_R 350_I 1.221 0.72
236_N 425_I 1.22 0.72
399_A 406_T 1.217 0.71
102_F 374_L 1.214 0.71
450_A 458_L 1.212 0.71
48_Q 51_A 1.204 0.70
23_V 126_V 1.201 0.70
482_R 487_T 1.199 0.70
133_A 167_P 1.198 0.70
307_S 332_L 1.194 0.69
40_A 43_R 1.194 0.69
445_I 449_C 1.194 0.69
131_A 139_W 1.192 0.69
411_C 414_V 1.189 0.69
407_V 424_I 1.183 0.68
22_M 60_L 1.17 0.67
310_T 323_M 1.168 0.67
186_S 189_I 1.167 0.67
475_S 482_R 1.159 0.66
8_M 12_E 1.159 0.66
361_Y 438_P 1.157 0.66
125_A 154_A 1.157 0.66
397_S 427_E 1.157 0.66
106_H 420_S 1.157 0.66
409_P 461_Y 1.151 0.65
176_V 187_V 1.15 0.65
296_L 301_I 1.148 0.65
10_A 13_A 1.146 0.65
56_Q 80_S 1.143 0.64
290_E 313_A 1.141 0.64
185_N 190_F 1.14 0.64
10_A 212_V 1.139 0.64
228_P 232_Q 1.135 0.64
168_R 324_D 1.135 0.64
283_M 292_V 1.134 0.64
424_I 433_L 1.132 0.63
231_Q 274_E 1.126 0.63
236_N 430_I 1.124 0.63
31_A 308_S 1.121 0.62
274_E 317_R 1.113 0.61
151_L 201_V 1.108 0.61
407_V 450_A 1.105 0.61
443_R 447_D 1.104 0.61
475_S 486_A 1.103 0.60
183_R 191_H 1.102 0.60
180_A 183_R 1.095 0.60
198_T 202_Q 1.09 0.59
308_S 335_Q 1.088 0.59
296_L 305_S 1.083 0.58
139_W 200_Y 1.083 0.58
315_S 318_K 1.08 0.58
382_G 416_H 1.08 0.58
101_S 439_L 1.078 0.58
20_N 56_Q 1.076 0.58
265_N 291_S 1.075 0.57
231_Q 235_D 1.07 0.57
167_P 325_Y 1.069 0.57
140_L 151_L 1.065 0.56
356_L 399_A 1.062 0.56
316_L 320_Y 1.062 0.56
186_S 190_F 1.061 0.56
252_P 279_P 1.06 0.56
26_S 128_E 1.06 0.56
245_M 275_N 1.06 0.56
261_V 287_V 1.059 0.56
17_I 124_V 1.058 0.56
479_D 482_R 1.056 0.55
58_R 80_S 1.051 0.55
444_T 448_N 1.05 0.55
340_N 390_L 1.05 0.55
440_Q 443_R 1.049 0.55
180_A 185_N 1.049 0.55
22_M 120_G 1.047 0.54
131_A 170_A 1.044 0.54
285_S 292_V 1.04 0.54
37_L 212_V 1.04 0.54
457_Y 480_L 1.039 0.54
479_D 487_T 1.036 0.53
360_I 458_L 1.035 0.53
111_A 149_T 1.032 0.53
464_N 473_D 1.032 0.53
398_I 453_M 1.032 0.53
478_F 482_R 1.03 0.53
94_K 100_V 1.029 0.53
189_I 484_L 1.028 0.52
189_I 242_L 1.023 0.52
295_L 298_T 1.022 0.52
358_F 445_I 1.022 0.52
16_I 209_V 1.021 0.52
291_S 354_V 1.02 0.52
341_P 345_R 1.019 0.51
164_Y 215_N 1.019 0.51
189_I 480_L 1.018 0.51
12_E 302_S 1.018 0.51
294_H 453_M 1.016 0.51
483_N 489_S 1.014 0.51
263_N 378_I 1.011 0.51
454_Y 457_Y 1.009 0.50
446_I 458_L 1.009 0.50
191_H 243_Q 1.008 0.50
13_A 17_I 1.007 0.50
166_D 320_Y 1.004 0.50
14_A 41_I 1.003 0.50
309_L 339_N 1.003 0.50
135_D 167_P 1.003 0.50
353_N 380_G 1.001 0.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2nvvA60.99391000.23Contact Map0.676
2g39A20.98781000.234Contact Map0.738
4eu9A20.9981000.235Contact Map0.721
3qliA20.83541000.387Contact Map0.735
3eh7A10.82721000.389Contact Map0.706
2oasA20.83741000.393Contact Map0.732
3gk7A20.85371000.395Contact Map0.731
3d3uA10.83941000.405Contact Map0.697
2hj0A20.8741000.495Contact Map0.52
1xr4A20.84961000.515Contact Map0.548
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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