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OPENSEQ.org
HOA - 4-hydroxy-2-oxovalerate aldolase
UniProt: P51020 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13292
Length: 337 (315)
Sequences: 3093
Seq/Len: 9.82
HOA
Paralog alert: 0.55 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
196_M 212_A 3.618 1.00
127_R 161_T 3.293 1.00
147_N 150_K 2.856 1.00
120_A 124_Q 2.763 1.00
196_M 217_C 2.654 1.00
38_D 256_A 2.617 1.00
71_E 102_A 2.5 1.00
211_A 214_E 2.408 1.00
30_R 72_A 2.396 1.00
47_A 66_D 2.393 1.00
25_S 28_N 2.383 1.00
209_S 239_F 2.376 1.00
153_K 187_E 2.321 1.00
178_R 214_E 2.304 1.00
5_K 249_Q 2.17 1.00
196_M 220_I 2.146 1.00
178_R 215_E 2.137 1.00
153_K 157_G 2.089 1.00
100_W 131_M 2.061 1.00
150_K 154_L 2.057 1.00
154_L 157_G 2.049 1.00
185_K 194_T 2.045 1.00
126_A 133_T 2.041 1.00
124_Q 128_E 2.038 1.00
240_I 257_L 2.014 1.00
97_K 125_Y 1.997 1.00
213_V 243_A 1.955 1.00
98_N 101_Q 1.936 1.00
97_K 101_Q 1.927 1.00
182_R 215_E 1.926 1.00
35_A 259_D 1.899 1.00
123_I 133_T 1.874 1.00
209_S 220_I 1.848 1.00
34_K 38_D 1.835 1.00
256_A 259_D 1.83 1.00
35_A 263_D 1.792 1.00
240_I 252_T 1.783 1.00
146_E 183_A 1.765 1.00
34_K 76_V 1.762 1.00
41_V 252_T 1.743 1.00
125_Y 128_E 1.734 1.00
146_E 150_K 1.715 1.00
46_V 82_I 1.711 1.00
117_D 120_A 1.707 1.00
94_H 97_K 1.706 1.00
27_E 72_A 1.705 1.00
178_R 182_R 1.68 1.00
153_K 156_E 1.626 1.00
149_A 187_E 1.616 1.00
135_G 155_M 1.589 1.00
153_K 189_K 1.58 1.00
26_L 65_S 1.573 1.00
93_I 125_Y 1.556 1.00
30_R 76_V 1.549 1.00
145_P 183_A 1.542 1.00
31_Q 35_A 1.542 1.00
135_G 160_A 1.538 1.00
222_A 236_L 1.536 1.00
152_A 184_L 1.522 1.00
35_A 260_A 1.519 1.00
11_V 233_N 1.516 1.00
121_Q 124_Q 1.509 1.00
8_I 222_A 1.507 1.00
149_A 183_A 1.503 1.00
114_T 139_M 1.501 1.00
120_A 154_L 1.497 1.00
68_E 72_A 1.496 1.00
253_D 256_A 1.493 1.00
188_L 192_T 1.489 1.00
6_L 213_V 1.487 1.00
44_I 77_V 1.481 1.00
178_R 211_A 1.447 1.00
156_E 192_T 1.441 1.00
260_A 263_D 1.435 1.00
38_D 259_D 1.43 1.00
73_A 77_V 1.402 0.99
36_L 44_I 1.401 0.99
175_S 179_D 1.393 0.99
120_A 158_Y 1.391 0.99
72_A 75_D 1.387 0.99
93_I 121_Q 1.383 0.99
244_D 249_Q 1.38 0.99
182_R 186_A 1.37 0.99
34_K 37_D 1.36 0.99
43_S 83_A 1.36 0.99
137_L 151_Q 1.349 0.99
211_A 215_E 1.348 0.99
39_A 256_A 1.345 0.99
106_V 132_D 1.338 0.99
72_A 76_V 1.327 0.99
222_A 239_F 1.325 0.99
177_I 198_A 1.315 0.99
210_I 242_A 1.314 0.99
67_L 98_N 1.313 0.99
173_N 176_D 1.31 0.99
167_D 208_N 1.303 0.99
185_K 218_D 1.301 0.99
93_I 97_K 1.297 0.99
177_I 212_A 1.281 0.99
153_K 188_L 1.251 0.98
96_L 125_Y 1.25 0.98
149_A 153_K 1.236 0.98
26_L 30_R 1.231 0.98
100_W 129_L 1.221 0.98
206_V 238_V 1.217 0.98
181_F 196_M 1.207 0.98
145_P 149_A 1.206 0.98
152_A 188_L 1.193 0.98
141_H 177_I 1.178 0.98
209_S 234_A 1.172 0.97
31_Q 34_K 1.167 0.97
240_I 250_H 1.163 0.97
112_H 115_E 1.15 0.97
209_S 213_V 1.145 0.97
81_K 132_D 1.144 0.97
28_N 31_Q 1.141 0.97
243_A 248_W 1.141 0.97
84_T 104_A 1.14 0.97
30_R 73_A 1.14 0.97
137_L 152_A 1.14 0.97
24_Y 29_V 1.137 0.97
7_Y 219_R 1.13 0.97
183_A 187_E 1.127 0.97
195_G 219_R 1.121 0.96
240_I 254_L 1.121 0.96
298_A 301_R 1.116 0.96
206_V 242_A 1.112 0.96
96_L 129_L 1.108 0.96
4_K 218_D 1.092 0.96
205_G 234_A 1.089 0.96
57_F 68_E 1.082 0.95
218_D 248_W 1.079 0.95
165_V 181_F 1.074 0.95
279_T 282_L 1.073 0.95
312_E 315_K 1.068 0.95
156_E 191_E 1.063 0.95
308_D 311_V 1.054 0.94
37_D 80_A 1.05 0.94
209_S 233_N 1.049 0.94
149_A 188_L 1.046 0.94
20_I 227_M 1.044 0.94
165_V 184_L 1.042 0.94
46_V 70_I 1.042 0.94
258_M 262_D 1.04 0.94
113_C 143_T 1.039 0.94
147_N 151_Q 1.034 0.94
140_S 166_V 1.025 0.93
198_A 212_A 1.017 0.93
73_A 82_I 1.015 0.93
113_C 137_L 1.015 0.93
13_L 44_I 1.013 0.93
151_Q 154_L 1.006 0.92
117_D 121_Q 1.005 0.92
13_L 33_A 1.003 0.92
30_R 34_K 1.003 0.92
136_F 166_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4jn6A211000.139Contact Map0.697
1nvmA411000.146Contact Map0.741
4lrtA211000.16Contact Map0.721
1rqbA10.97631000.232Contact Map0.734
3bg3A40.97331000.236Contact Map0.72
2qf7A20.97031000.25Contact Map0.717
3hblA40.97031000.251Contact Map0.776
2nx9A20.97031000.268Contact Map0.756
3bleA10.87241000.285Contact Map0.69
2ztjA10.92581000.293Contact Map0.71
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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