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OPENSEQ.org
GSPH - Putative type II secretion system protein H
UniProt: P41443 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12887
Length: 169 (161)
Sequences: 332
Seq/Len: 2.06
GSPH
Paralog alert: 0.20 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
17_A 20_A 2.361 1.00
6_G 9_L 2.318 1.00
64_P 128_A 1.907 0.99
54_A 65_V 1.872 0.98
6_G 11_E 1.806 0.98
16_L 19_V 1.805 0.98
103_W 109_I 1.784 0.97
43_T 46_R 1.728 0.97
122_P 131_Q 1.69 0.96
7_F 11_E 1.646 0.95
12_M 23_A 1.614 0.95
66_G 123_Q 1.612 0.95
88_W 135_F 1.567 0.94
40_A 139_M 1.545 0.93
8_T 11_E 1.514 0.92
47_F 137_L 1.479 0.91
57_R 61_S 1.467 0.90
10_L 14_L 1.466 0.90
153_C 157_W 1.417 0.88
77_M 106_E 1.415 0.88
66_G 122_P 1.395 0.87
43_T 50_A 1.359 0.85
20_A 74_W 1.342 0.84
90_P 95_A 1.331 0.83
3_Q 99_S 1.308 0.82
136_S 152_V 1.3 0.81
8_T 15_V 1.3 0.81
31_G 38_T 1.29 0.81
24_S 28_F 1.287 0.81
58_A 128_A 1.287 0.81
51_L 126_I 1.274 0.80
47_F 151_L 1.273 0.80
40_A 113_P 1.26 0.79
15_V 137_L 1.254 0.78
57_R 94_D 1.251 0.78
66_G 131_Q 1.245 0.77
46_R 134_P 1.24 0.77
50_A 101_N 1.225 0.76
69_F 137_L 1.219 0.75
44_A 161_Q 1.214 0.75
26_V 50_A 1.176 0.72
60_L 88_W 1.162 0.70
74_W 129_D 1.161 0.70
94_D 98_E 1.158 0.70
113_P 117_D 1.142 0.68
1_M 146_E 1.142 0.68
51_L 94_D 1.141 0.68
135_F 153_C 1.137 0.68
122_P 160_D 1.132 0.67
66_G 135_F 1.12 0.66
94_D 97_D 1.12 0.66
13_M 113_P 1.118 0.66
50_A 74_W 1.115 0.66
109_I 141_N 1.11 0.65
39_R 59_T 1.106 0.65
22_T 25_V 1.09 0.63
111_L 137_L 1.085 0.62
29_T 63_Q 1.079 0.62
64_P 103_W 1.074 0.61
103_W 113_P 1.073 0.61
49_A 52_E 1.073 0.61
25_V 29_T 1.068 0.61
153_C 159_L 1.065 0.60
13_M 161_Q 1.062 0.60
13_M 57_R 1.06 0.60
18_L 54_A 1.059 0.60
60_L 74_W 1.058 0.60
122_P 135_F 1.053 0.59
89_V 124_V 1.053 0.59
26_V 158_P 1.044 0.58
20_A 144_T 1.043 0.58
12_M 122_P 1.041 0.58
66_G 88_W 1.04 0.58
126_I 132_I 1.036 0.57
55_I 126_I 1.033 0.57
49_A 125_V 1.028 0.56
113_P 130_G 1.028 0.56
10_L 141_N 1.025 0.56
56_D 74_W 1.02 0.55
64_P 129_D 1.02 0.55
131_Q 135_F 1.011 0.54
124_V 152_V 1.011 0.54
5_R 137_L 1.01 0.54
43_T 134_P 1.01 0.54
60_L 137_L 1.003 0.54
17_A 54_A 1.002 0.53
41_R 159_L 1 0.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2knqA10.834399.90.388Contact Map0.355
4dq9A20.769299.90.432Contact Map0.428
1oqwA20.78798.30.778Contact Map0.277
3sokA20.822597.80.801Contact Map0.334
2m7gA10.360997.80.801Contact Map0.344
2hi2A10.798897.40.819Contact Map0.335
2xr4A20.42613.50.935Contact Map0.257
2bv4A20.414213.10.936Contact Map0.28
2chhA10.42015.90.945Contact Map0.322
3fzyA20.5684.30.948Contact Map0.249
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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