| UniProt: | P38489 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG20151 | ||
| Length: | 217 (217) | ||
| Sequences: | 4448 | ||
| Seq/Len: | 20.50 |
| NFNB
Paralog alert: 0.74 [within 20: 0.04] - ratio of genomes with paralogs Cluster includes: NFNB RUTE YDJA |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 17_D | 20_K | 4.034 | 1.00 | |
| 23_T | 26_Q | 4.011 | 1.00 | |
| 29_Q | 157_L | 3.76 | 1.00 | |
| 24_P | 52_S | 3.364 | 1.00 | |
| 48_F | 146_N | 3.009 | 1.00 | |
| 30_I | 154_V | 2.877 | 1.00 | |
| 20_K | 193_H | 2.873 | 1.00 | |
| 24_P | 28_E | 2.829 | 1.00 | |
| 47_H | 215_T | 2.785 | 1.00 | |
| 32_T | 35_Q | 2.519 | 1.00 | |
| 48_F | 82_V | 2.507 | 1.00 | |
| 160_D | 194_H | 2.465 | 1.00 | |
| 159_L | 193_H | 2.422 | 1.00 | |
| 151_L | 161_A | 2.38 | 1.00 | |
| 54_E | 58_A | 2.338 | 1.00 | |
| 26_Q | 159_L | 2.263 | 1.00 | |
| 59_R | 175_E | 2.251 | 1.00 | |
| 173_D | 185_S | 2.131 | 1.00 | |
| 154_V | 191_V | 2.053 | 1.00 | |
| 34_L | 150_F | 2.035 | 1.00 | |
| 171_I | 174_A | 1.971 | 1.00 | |
| 31_K | 214_L | 1.964 | 1.00 | |
| 61_A | 76_L | 1.923 | 1.00 | |
| 168_D | 171_I | 1.92 | 1.00 | |
| 82_V | 150_F | 1.842 | 1.00 | |
| 9_K | 155_A | 1.83 | 1.00 | |
| 28_E | 211_N | 1.804 | 1.00 | |
| 26_Q | 157_L | 1.802 | 1.00 | |
| 50_V | 80_H | 1.788 | 1.00 | |
| 208_L | 212_I | 1.784 | 1.00 | |
| 58_A | 76_L | 1.751 | 1.00 | |
| 159_L | 191_V | 1.748 | 1.00 | |
| 86_A | 139_M | 1.737 | 1.00 | |
| 17_D | 195_S | 1.704 | 1.00 | |
| 30_I | 150_F | 1.702 | 1.00 | |
| 16_F | 190_P | 1.685 | 1.00 | |
| 3_I | 6_V | 1.676 | 1.00 | |
| 5_S | 9_K | 1.675 | 1.00 | |
| 141_K | 144_Y | 1.671 | 1.00 | |
| 83_V | 188_V | 1.645 | 1.00 | |
| 3_I | 7_A | 1.631 | 1.00 | |
| 147_V | 187_V | 1.612 | 1.00 | |
| 60_V | 172_L | 1.557 | 1.00 | |
| 155_A | 160_D | 1.525 | 1.00 | |
| 33_L | 153_G | 1.514 | 1.00 | |
| 151_L | 189_V | 1.51 | 1.00 | |
| 30_I | 191_V | 1.498 | 1.00 | |
| 210_Q | 214_L | 1.476 | 1.00 | |
| 22_L | 159_L | 1.45 | 1.00 | |
| 56_G | 59_R | 1.441 | 1.00 | |
| 154_V | 161_A | 1.421 | 1.00 | |
| 85_C | 183_Y | 1.416 | 1.00 | |
| 49_I | 85_C | 1.407 | 0.99 | |
| 53_T | 56_G | 1.396 | 0.99 | |
| 55_E | 59_R | 1.39 | 0.99 | |
| 50_V | 214_L | 1.39 | 0.99 | |
| 151_L | 163_P | 1.375 | 0.99 | |
| 85_C | 178_L | 1.372 | 0.99 | |
| 26_Q | 193_H | 1.371 | 0.99 | |
| 26_Q | 29_Q | 1.363 | 0.99 | |
| 30_I | 159_L | 1.355 | 0.99 | |
| 33_L | 157_L | 1.353 | 0.99 | |
| 48_F | 84_F | 1.336 | 0.99 | |
| 15_A | 195_S | 1.334 | 0.99 | |
| 63_S | 175_E | 1.322 | 0.99 | |
| 58_A | 62_K | 1.322 | 0.99 | |
| 170_A | 174_A | 1.298 | 0.99 | |
| 145_L | 148_G | 1.29 | 0.99 | |
| 37_S | 149_N | 1.286 | 0.99 | |
| 63_S | 171_I | 1.268 | 0.99 | |
| 56_G | 175_E | 1.265 | 0.99 | |
| 147_V | 189_V | 1.259 | 0.99 | |
| 163_P | 187_V | 1.249 | 0.99 | |
| 28_E | 32_T | 1.237 | 0.98 | |
| 150_F | 189_V | 1.232 | 0.98 | |
| 35_Q | 213_T | 1.226 | 0.98 | |
| 84_F | 150_F | 1.224 | 0.98 | |
| 143_V | 186_L | 1.221 | 0.98 | |
| 25_E | 28_E | 1.204 | 0.98 | |
| 22_L | 26_Q | 1.197 | 0.98 | |
| 55_E | 58_A | 1.178 | 0.98 | |
| 47_H | 183_Y | 1.174 | 0.98 | |
| 21_K | 52_S | 1.148 | 0.97 | |
| 27_A | 80_H | 1.138 | 0.97 | |
| 8_L | 32_T | 1.131 | 0.97 | |
| 4_I | 29_Q | 1.123 | 0.97 | |
| 84_F | 143_V | 1.121 | 0.97 | |
| 179_K | 182_G | 1.118 | 0.96 | |
| 5_S | 8_L | 1.117 | 0.96 | |
| 100_D | 104_A | 1.107 | 0.96 | |
| 84_F | 147_V | 1.106 | 0.96 | |
| 28_E | 210_Q | 1.101 | 0.96 | |
| 83_V | 176_F | 1.096 | 0.96 | |
| 49_I | 217_V | 1.073 | 0.95 | |
| 141_K | 165_E | 1.073 | 0.95 | |
| 87_K | 182_G | 1.071 | 0.95 | |
| 51_A | 83_V | 1.069 | 0.95 | |
| 7_A | 149_N | 1.058 | 0.95 | |
| 169_A | 185_S | 1.058 | 0.95 | |
| 149_N | 152_L | 1.053 | 0.95 | |
| 161_A | 191_V | 1.049 | 0.94 | |
| 161_A | 189_V | 1.045 | 0.94 | |
| 39_S | 46_W | 1.039 | 0.94 | |
| 23_T | 193_H | 1.032 | 0.94 | |
| 7_A | 152_L | 1.03 | 0.94 | |
| 147_V | 163_P | 1.029 | 0.94 | |
| 171_I | 175_E | 1.019 | 0.93 | |
| 148_G | 152_L | 1.016 | 0.93 | |
| 30_I | 157_L | 1.01 | 0.93 | |
| 2_D | 5_S | 1.009 | 0.93 | |
| 31_K | 50_V | 1.007 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1icrA | 2 | 0.9954 | 100 | 0.143 | Contact Map | 0.788 |
| 3of4A | 3 | 0.9539 | 100 | 0.149 | Contact Map | 0.817 |
| 1vfrA | 2 | 0.9862 | 100 | 0.153 | Contact Map | 0.798 |
| 3bemA | 2 | 0.9401 | 100 | 0.154 | Contact Map | 0.875 |
| 3gagA | 4 | 0.9263 | 100 | 0.161 | Contact Map | 0.847 |
| 3ge6A | 2 | 0.9355 | 100 | 0.164 | Contact Map | 0.792 |
| 1noxA | 1 | 0.9124 | 100 | 0.168 | Contact Map | 0.762 |
| 3gbhA | 4 | 0.9355 | 100 | 0.175 | Contact Map | 0.856 |
| 2b67A | 4 | 0.9263 | 100 | 0.181 | Contact Map | 0.857 |
| 2hayA | 4 | 0.9309 | 100 | 0.182 | Contact Map | 0.833 |
Sequence Conservation (Image Generated using WebLogo v3)