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OPENSEQ.org
HOFQ - Putative DNA transport protein HofQ
UniProt: P34749 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12113
Length: 412 (394)
Sequences: 1402
Seq/Len: 3.56
HOFQ
Paralog alert: 0.55 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
374_S 379_G 6.736 1.00
386_Q 389_R 4.945 1.00
374_S 380_D 4.551 1.00
381_I 384_F 4.355 1.00
272_P 305_E 4.064 1.00
120_R 168_E 3.7 1.00
357_T 405_T 2.802 1.00
320_L 404_I 2.723 1.00
280_E 299_E 2.593 1.00
280_E 298_K 2.382 1.00
276_K 299_E 2.374 1.00
272_P 307_T 2.139 1.00
377_L 380_D 2.112 1.00
321_H 347_E 2.063 1.00
353_K 356_E 2.061 1.00
30_D 57_T 2.043 1.00
122_I 164_L 1.981 1.00
188_V 403_F 1.967 1.00
62_L 70_A 1.96 1.00
153_N 175_D 1.932 1.00
122_I 157_L 1.923 1.00
377_L 381_I 1.907 1.00
26_L 70_A 1.871 1.00
386_Q 391_D 1.868 1.00
157_L 167_L 1.857 1.00
370_S 393_K 1.851 0.99
277_Q 363_I 1.826 0.99
181_V 310_V 1.785 0.99
159_D 163_A 1.759 0.99
321_H 345_E 1.734 0.99
279_S 342_D 1.726 0.99
189_T 344_Q 1.698 0.99
128_D 131_E 1.656 0.99
193_K 255_Q 1.627 0.98
374_S 389_R 1.626 0.98
193_K 396_E 1.612 0.98
366_R 397_R 1.587 0.98
36_V 74_V 1.579 0.98
161_K 165_S 1.572 0.98
146_M 157_L 1.562 0.98
258_D 397_R 1.557 0.98
33_V 74_V 1.549 0.98
385_G 389_R 1.537 0.97
282_P 297_F 1.527 0.97
129_A 153_N 1.521 0.97
31_V 36_V 1.519 0.97
283_Y 297_F 1.51 0.97
352_V 358_L 1.51 0.97
124_L 132_L 1.508 0.97
168_E 172_A 1.506 0.97
249_S 390_H 1.504 0.97
141_S 159_D 1.502 0.97
130_G 150_K 1.478 0.97
155_L 167_L 1.478 0.97
51_S 96_W 1.47 0.96
261_A 277_Q 1.453 0.96
144_G 159_D 1.448 0.96
185_A 404_I 1.442 0.96
315_R 353_K 1.44 0.96
319_K 349_Q 1.435 0.96
359_A 403_F 1.43 0.96
46_L 84_Q 1.418 0.95
300_A 341_I 1.415 0.95
122_I 171_V 1.414 0.95
280_E 341_I 1.406 0.95
371_G 381_I 1.405 0.95
66_P 69_Q 1.395 0.95
299_E 343_K 1.393 0.95
269_H 310_V 1.391 0.95
348_T 407_R 1.389 0.95
102_A 106_A 1.384 0.94
344_Q 365_T 1.384 0.94
277_Q 344_Q 1.374 0.94
372_Q 389_R 1.37 0.94
32_P 35_Q 1.368 0.94
265_L 346_I 1.359 0.94
376_P 382_P 1.359 0.94
84_Q 89_L 1.352 0.94
346_I 360_L 1.341 0.93
127_A 151_R 1.339 0.93
319_K 347_E 1.326 0.93
118_E 164_L 1.324 0.93
124_L 148_V 1.305 0.92
141_S 144_G 1.299 0.92
65_V 70_A 1.291 0.91
187_I 283_Y 1.291 0.91
380_D 389_R 1.289 0.91
263_P 273_A 1.287 0.91
265_L 360_L 1.286 0.91
32_P 57_T 1.272 0.90
157_L 164_L 1.27 0.90
132_L 171_V 1.259 0.90
197_E 249_S 1.248 0.89
34_A 38_Q 1.245 0.89
48_L 91_V 1.238 0.89
275_I 359_A 1.231 0.88
41_A 48_L 1.218 0.88
28_V 36_V 1.212 0.87
37_L 48_L 1.212 0.87
303_G 323_S 1.207 0.87
318_L 352_V 1.196 0.87
366_R 395_D 1.196 0.87
184_S 405_T 1.193 0.86
263_P 362_G 1.186 0.86
326_V 342_D 1.181 0.86
301_V 324_Q 1.175 0.85
350_V 358_L 1.175 0.85
190_I 194_S 1.171 0.85
124_L 171_V 1.17 0.85
127_A 174_M 1.169 0.85
275_I 361_G 1.169 0.85
379_G 389_R 1.168 0.85
283_Y 339_L 1.164 0.84
28_V 31_V 1.162 0.84
280_E 343_K 1.16 0.84
127_A 149_D 1.148 0.83
62_L 65_V 1.147 0.83
163_A 166_A 1.147 0.83
378_L 381_I 1.143 0.83
131_E 271_Q 1.143 0.83
159_D 164_L 1.135 0.82
284_Q 336_G 1.134 0.82
72_Q 82_T 1.133 0.82
352_V 406_P 1.133 0.82
376_P 388_F 1.13 0.82
179_G 310_V 1.128 0.82
298_K 301_V 1.126 0.82
120_R 164_L 1.121 0.81
108_Q 111_A 1.119 0.81
269_H 309_T 1.114 0.81
163_A 360_L 1.111 0.80
199_G 202_W 1.111 0.80
182_E 407_R 1.108 0.80
278_G 282_P 1.107 0.80
271_Q 360_L 1.107 0.80
104_Q 108_Q 1.102 0.80
368_N 395_D 1.101 0.80
160_N 163_A 1.101 0.80
17_Q 21_P 1.099 0.79
267_A 273_A 1.097 0.79
130_G 134_K 1.092 0.79
52_P 78_A 1.091 0.79
82_T 89_L 1.069 0.77
80_L 91_V 1.065 0.76
285_V 296_E 1.063 0.76
370_S 391_D 1.062 0.76
295_V 336_G 1.058 0.76
229_T 394_E 1.051 0.75
40_L 70_A 1.05 0.75
301_V 325_N 1.046 0.75
322_I 325_N 1.044 0.74
315_R 351_E 1.039 0.74
44_E 48_L 1.038 0.74
127_A 132_L 1.038 0.74
75_V 82_T 1.035 0.73
121_S 156_L 1.03 0.73
251_L 257_L 1.028 0.73
109_A 112_Q 1.027 0.73
178_V 402_V 1.024 0.72
28_V 39_A 1.024 0.72
36_V 58_V 1.021 0.72
209_H 213_V 1.021 0.72
316_I 406_P 1.02 0.72
287_S 292_A 1.015 0.71
136_G 155_L 1.014 0.71
267_A 302_L 1.014 0.71
159_D 167_L 1.012 0.71
25_T 128_D 1.01 0.71
39_A 70_A 1.01 0.71
316_I 352_V 1.009 0.71
274_S 305_E 1.009 0.71
103_R 106_A 1.009 0.71
273_A 403_F 1.009 0.71
284_Q 295_V 1.006 0.70
169_Q 172_A 1.004 0.70
185_A 304_M 1.002 0.70
25_T 63_T 1 0.70
383_W 386_Q 1 0.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4av2A120.98791000.138Contact Map0.704
4g08A10.37141000.71Contact Map0.688
2y3mA20.40531000.712Contact Map0.558
3ossD10.393299.90.721Contact Map0.59
3gr5A10.371499.90.729Contact Map0.631
4e9jA20.572899.90.753Contact Map0.683
3ezjA40.393299.90.754Contact Map0.755
4jtmA20.184599.40.845Contact Map0.702
4ar0A10.281699.20.86Contact Map0.707
2a02A10.191796.60.926Contact Map0.533
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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