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OPENSEQ.org
SELU - tRNA 2-selenouridine synthase
UniProt: P33667 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11768
Length: 364 (359)
Sequences: 440
Seq/Len: 1.23
SELU
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
27_I 45_N 2.879 1.00
49_A 53_T 2.704 1.00
46_D 50_A 2.534 1.00
33_A 96_C 2.356 0.99
191_S 195_L 2.192 0.99
283_H 306_D 2.116 0.98
54_C 66_L 2.078 0.98
50_A 66_L 2.067 0.98
128_L 194_N 1.969 0.97
353_E 356_E 1.92 0.96
105_H 120_L 1.894 0.95
64_L 102_Q 1.877 0.95
150_C 338_R 1.759 0.93
157_L 252_R 1.759 0.93
58_Q 62_A 1.749 0.92
51_V 66_L 1.729 0.92
166_V 230_L 1.709 0.91
60_S 102_Q 1.708 0.91
26_P 44_N 1.64 0.89
26_P 45_N 1.634 0.88
50_A 70_L 1.632 0.88
157_L 255_E 1.615 0.88
219_R 228_E 1.611 0.87
154_G 256_E 1.606 0.87
221_I 226_L 1.579 0.86
250_L 325_L 1.558 0.85
154_G 252_R 1.554 0.85
289_I 298_Y 1.536 0.84
245_P 248_I 1.528 0.83
31_H 190_A 1.515 0.83
60_S 64_L 1.512 0.83
17_D 202_K 1.495 0.82
146_L 214_L 1.493 0.81
42_L 293_L 1.486 0.81
158_L 242_V 1.485 0.81
253_L 325_L 1.472 0.80
247_E 326_V 1.453 0.79
162_Q 213_V 1.447 0.79
25_A 49_A 1.441 0.78
244_D 252_R 1.419 0.77
153_S 244_D 1.417 0.77
108_Q 120_L 1.411 0.76
59_G 293_L 1.409 0.76
159_V 165_G 1.404 0.76
108_Q 118_Y 1.401 0.75
56_K 329_L 1.388 0.74
29_F 39_N 1.369 0.73
283_H 302_A 1.354 0.72
148_G 239_I 1.352 0.72
336_M 340_Q 1.349 0.71
325_L 329_L 1.346 0.71
311_T 315_T 1.33 0.70
171_L 285_G 1.326 0.70
214_L 234_M 1.324 0.69
32_G 194_N 1.321 0.69
273_Q 277_E 1.311 0.68
326_V 330_E 1.295 0.67
263_H 314_T 1.294 0.67
133_I 193_E 1.287 0.66
260_R 264_D 1.287 0.66
178_A 336_M 1.282 0.66
285_G 288_A 1.278 0.65
311_T 314_T 1.269 0.65
321_H 324_W 1.268 0.65
179_F 285_G 1.26 0.64
196_L 224_N 1.256 0.63
29_F 196_L 1.256 0.63
146_L 234_M 1.252 0.63
43_M 68_H 1.251 0.63
96_C 190_A 1.251 0.63
23_V 44_N 1.245 0.62
20_I 75_I 1.24 0.62
244_D 248_I 1.229 0.61
159_V 260_R 1.224 0.61
147_I 317_S 1.214 0.60
220_M 223_S 1.214 0.60
56_K 126_K 1.208 0.59
301_L 332_Y 1.199 0.58
285_G 332_Y 1.197 0.58
197_A 201_L 1.193 0.58
85_A 88_L 1.192 0.57
224_N 230_L 1.186 0.57
110_W 325_L 1.185 0.57
8_Q 363_A 1.177 0.56
144_I 166_V 1.175 0.56
179_F 340_Q 1.167 0.55
178_A 294_G 1.166 0.55
137_I 229_C 1.166 0.55
153_S 185_P 1.165 0.55
251_E 255_E 1.164 0.55
73_G 175_R 1.162 0.55
179_F 286_L 1.156 0.54
45_N 82_A 1.155 0.54
313_L 356_E 1.154 0.54
263_H 266_T 1.149 0.53
98_A 190_A 1.148 0.53
46_D 49_A 1.142 0.53
315_T 359_E 1.14 0.52
226_L 231_R 1.139 0.52
13_L 353_E 1.138 0.52
290_K 295_L 1.138 0.52
175_R 274_G 1.135 0.52
324_W 328_L 1.132 0.52
56_K 59_G 1.132 0.52
148_G 216_D 1.131 0.52
78_Q 82_A 1.129 0.51
9_D 12_A 1.127 0.51
146_L 322_L 1.127 0.51
262_H 266_T 1.126 0.51
307_A 326_V 1.124 0.51
291_R 294_G 1.122 0.51
43_M 51_V 1.12 0.50
59_G 294_G 1.12 0.50
128_L 282_L 1.118 0.50
358_A 362_K 1.115 0.50
148_G 329_L 1.111 0.50
34_M 96_C 1.106 0.49
313_L 359_E 1.102 0.49
272_E 314_T 1.1 0.49
5_H 353_E 1.098 0.48
288_A 339_Y 1.093 0.48
77_Q 81_D 1.093 0.48
154_G 244_D 1.091 0.48
264_D 357_V 1.091 0.48
111_L 238_A 1.089 0.47
26_P 176_G 1.086 0.47
9_D 359_E 1.086 0.47
12_A 268_A 1.084 0.47
271_D 313_L 1.079 0.46
315_T 358_A 1.079 0.46
57_Q 67_G 1.075 0.46
235_T 344_K 1.074 0.46
221_I 224_N 1.072 0.46
199_E 203_T 1.07 0.46
5_H 359_E 1.065 0.45
108_Q 119_P 1.062 0.45
12_A 267_H 1.062 0.45
108_Q 112_H 1.06 0.45
61_D 84_R 1.059 0.45
204_D 360_W 1.056 0.44
179_F 196_L 1.051 0.44
358_A 363_A 1.048 0.43
289_I 305_L 1.048 0.43
62_A 65_A 1.047 0.43
179_F 289_I 1.042 0.43
251_E 342_E 1.038 0.42
144_I 156_T 1.038 0.42
289_I 345_A 1.036 0.42
179_F 293_L 1.034 0.42
171_L 199_E 1.031 0.42
263_H 362_K 1.031 0.42
27_I 44_N 1.031 0.42
154_G 231_R 1.031 0.42
196_L 226_L 1.03 0.42
266_T 271_D 1.029 0.42
48_R 98_A 1.029 0.42
121_V 298_Y 1.028 0.42
81_D 85_A 1.028 0.42
61_D 332_Y 1.022 0.41
80_M 214_L 1.02 0.41
296_Q 300_E 1.019 0.41
111_L 132_A 1.018 0.41
21_I 53_T 1.018 0.41
194_N 293_L 1.014 0.40
96_C 191_S 1.014 0.40
79_R 83_W 1.013 0.40
144_I 233_R 1.012 0.40
282_L 321_H 1.01 0.40
74_E 79_R 1.009 0.40
251_E 322_L 1.007 0.40
194_N 289_I 1.006 0.39
66_L 70_L 1.003 0.39
359_E 363_A 1.001 0.39
82_A 283_H 1 0.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1okgA10.53021000.8Contact Map0.183
3g5jA20.362699.90.816Contact Map0.627
3icsA20.280299.80.854Contact Map0.597
3ntdA20.26199.70.864Contact Map0.764
3gk5A10.29499.70.867Contact Map0.607
3fojA10.269299.70.871Contact Map0.668
1gmxA10.285799.70.872Contact Map0.568
3flhA30.291299.70.872Contact Map0.851
1tq1A10.310499.70.873Contact Map0.122
3nhvA50.346299.60.874Contact Map0.585
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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