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SFGH2 - S-formylglutathione hydrolase YeiG
UniProt: P33018 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12026
Length: 278 (274)
Sequences: 3320
Seq/Len: 12.12
SFGH2
Paralog alert: 0.60 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: SFGH1 SFGH2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
155_A 165_V 4.042 1.00
105_N 119_D 3.866 1.00
130_Q 139_C 3.139 1.00
130_Q 135_V 3.039 1.00
236_A 240_R 2.884 1.00
167_A 170_P 2.874 1.00
75_V 135_V 2.86 1.00
20_D 27_P 2.642 1.00
118_Y 158_N 2.535 1.00
46_L 142_S 2.512 1.00
96_L 186_S 2.495 1.00
181_I 192_K 2.381 1.00
119_D 123_D 2.319 1.00
43_P 75_V 2.245 1.00
238_A 242_K 2.177 1.00
21_S 124_E 2.134 1.00
38_R 134_N 2.123 1.00
165_V 215_T 2.097 1.00
166_S 268_H 2.096 1.00
46_L 74_I 2.082 1.00
249_R 267_D 2.068 1.00
20_D 25_N 2.065 1.00
45_V 77_V 2.028 1.00
236_A 246_M 1.989 1.00
221_D 252_P 1.974 1.00
18_R 27_P 1.905 1.00
168_F 268_H 1.901 1.00
77_V 129_V 1.897 1.00
47_Y 139_C 1.858 1.00
37_P 73_G 1.852 1.00
67_R 71_E 1.846 1.00
32_I 77_V 1.818 1.00
129_V 135_V 1.783 1.00
72_L 269_L 1.759 1.00
47_Y 130_Q 1.738 1.00
153_I 198_W 1.733 1.00
128_L 132_Q 1.714 1.00
18_R 29_T 1.709 1.00
86_E 98_Q 1.67 1.00
218_D 264_F 1.643 1.00
118_Y 154_M 1.629 1.00
34_L 75_V 1.622 1.00
48_W 142_S 1.601 1.00
48_W 59_F 1.567 1.00
16_R 29_T 1.53 1.00
38_R 43_P 1.527 1.00
237_E 241_Q 1.521 1.00
118_Y 157_K 1.514 1.00
193_N 196_L 1.507 1.00
217_I 235_L 1.506 1.00
126_P 162_Y 1.505 1.00
105_N 116_R 1.505 1.00
45_V 135_V 1.485 1.00
65_A 76_L 1.478 1.00
266_E 270_R 1.476 1.00
19_H 120_Y 1.474 1.00
23_T 119_D 1.46 1.00
126_P 139_C 1.454 1.00
169_A 261_I 1.446 1.00
122_R 158_N 1.432 1.00
226_L 230_L 1.427 1.00
41_T 73_G 1.426 1.00
196_L 202_A 1.423 1.00
21_S 24_L 1.408 1.00
91_D 98_Q 1.405 0.99
221_D 250_I 1.4 0.99
109_P 112_A 1.387 0.99
153_I 157_K 1.373 0.99
47_Y 126_P 1.368 0.99
120_Y 125_L 1.368 0.99
17_W 30_F 1.365 0.99
90_N 98_Q 1.351 0.99
239_A 246_M 1.345 0.99
3_M 6_E 1.341 0.99
87_K 98_Q 1.339 0.99
152_L 172_V 1.33 0.99
3_M 15_Q 1.302 0.99
123_D 127_A 1.284 0.99
126_P 161_K 1.258 0.99
149_H 200_S 1.258 0.99
123_D 158_N 1.257 0.99
236_A 250_I 1.254 0.99
29_T 56_D 1.24 0.98
238_A 241_Q 1.234 0.98
221_D 251_Q 1.234 0.98
122_R 161_K 1.23 0.98
216_L 249_R 1.225 0.98
173_N 234_V 1.215 0.98
194_A 197_E 1.214 0.98
37_P 43_P 1.205 0.98
47_Y 129_V 1.203 0.98
30_F 120_Y 1.189 0.98
15_Q 133_F 1.183 0.98
126_P 130_Q 1.183 0.98
230_L 250_I 1.175 0.98
149_H 153_I 1.175 0.98
28_M 120_Y 1.169 0.97
153_I 200_S 1.164 0.97
172_V 235_L 1.164 0.97
141_I 151_A 1.162 0.97
45_V 75_V 1.144 0.97
152_L 170_P 1.139 0.97
60_T 78_M 1.126 0.97
122_R 127_A 1.125 0.97
236_A 248_L 1.122 0.97
148_G 167_A 1.116 0.96
217_I 236_A 1.116 0.96
30_F 125_L 1.114 0.96
170_P 229_Q 1.109 0.96
204_M 242_K 1.109 0.96
75_V 133_F 1.106 0.96
99_G 102_F 1.103 0.96
63_A 258_Y 1.1 0.96
144_H 261_I 1.099 0.96
69_A 76_L 1.094 0.96
6_E 13_W 1.092 0.96
48_W 265_I 1.086 0.96
122_R 154_M 1.086 0.96
140_A 164_S 1.08 0.95
145_S 256_H 1.079 0.95
59_F 63_A 1.075 0.95
152_L 167_A 1.075 0.95
48_W 78_M 1.075 0.95
234_V 237_E 1.072 0.95
49_L 117_M 1.061 0.95
49_L 150_G 1.055 0.95
139_C 161_K 1.045 0.94
68_V 266_E 1.044 0.94
141_I 154_M 1.03 0.94
5_E 8_R 1.03 0.94
151_A 167_A 1.024 0.93
118_Y 122_R 1.024 0.93
121_L 154_M 1.016 0.93
17_W 128_L 1.015 0.93
158_N 161_K 1.015 0.93
47_Y 77_V 1.014 0.93
22_S 25_N 1.013 0.93
203_L 207_S 1.01 0.93
50_S 54_C 1.01 0.93
147_G 150_G 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4folA40.99641000.331Contact Map0.701
3ls2A40.99641000.337Contact Map0.827
4b6gA20.98921000.358Contact Map0.865
3i6yA20.99281000.377Contact Map0.804
3e4dA60.98921000.384Contact Map0.789
3fcxA20.99641000.397Contact Map0.834
2uz0A40.86331000.467Contact Map0.769
1jjfA10.83451000.489Contact Map0.823
4h18A40.92811000.493Contact Map0.751
1r88A20.89571000.495Contact Map0.737
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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