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OPENSEQ.org
OTSB - Trehalose-6-phosphate phosphatase
UniProt: P31678 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11752
Length: 266 (237)
Sequences: 1141
Seq/Len: 4.81
OTSB
Paralog alert: 0.11 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
196_L 236_V 3.686 1.00
60_S 67_L 3.25 1.00
219_I 236_V 2.529 1.00
195_F 205_G 2.5 1.00
162_G 165_V 2.474 1.00
31_H 34_Q 2.378 1.00
130_A 165_V 2.346 1.00
231_A 235_D 2.236 1.00
107_S 124_A 2.219 1.00
210_N 216_S 2.158 1.00
218_K 222_G 2.147 1.00
67_L 78_L 2.08 1.00
58_L 71_A 2.027 1.00
230_L 239_W 1.95 1.00
63_S 66_E 1.931 1.00
203_E 224_T 1.909 1.00
196_L 217_V 1.874 1.00
82_H 201_T 1.848 1.00
62_R 132_H 1.812 1.00
29_K 35_V 1.798 1.00
80_G 85_E 1.785 1.00
120_A 136_A 1.781 1.00
18_F 179_I 1.697 0.99
60_S 78_L 1.682 0.99
110_L 168_I 1.571 0.99
26_A 41_I 1.558 0.99
71_A 78_L 1.528 0.99
18_F 182_F 1.524 0.99
61_G 82_H 1.517 0.99
68_D 87_R 1.514 0.98
66_E 70_L 1.503 0.98
145_T 149_R 1.483 0.98
28_I 163_K 1.483 0.98
114_I 122_L 1.446 0.98
121_E 135_Q 1.436 0.98
40_N 237_W 1.432 0.98
81_V 85_E 1.404 0.97
47_L 69_A 1.399 0.97
41_I 44_G 1.395 0.97
15_Y 54_G 1.394 0.97
21_L 70_L 1.391 0.97
222_G 229_R 1.383 0.97
19_F 196_L 1.371 0.97
162_G 167_E 1.359 0.96
21_L 35_V 1.358 0.96
125_K 132_H 1.353 0.96
62_R 82_H 1.305 0.95
41_I 237_W 1.3 0.95
19_F 240_L 1.289 0.95
20_D 198_D 1.287 0.95
21_L 67_L 1.282 0.95
17_W 243_I 1.265 0.94
51_A 54_G 1.253 0.94
56_L 76_F 1.248 0.94
131_L 147_A 1.235 0.93
70_L 125_K 1.234 0.93
224_T 229_R 1.233 0.93
20_D 199_D 1.23 0.93
22_D 132_H 1.222 0.93
32_P 162_G 1.213 0.92
139_H 142_A 1.212 0.92
15_Y 51_A 1.206 0.92
17_W 48_L 1.206 0.92
21_L 26_A 1.195 0.91
113_V 146_L 1.193 0.91
110_L 122_L 1.187 0.91
203_E 226_A 1.184 0.91
40_N 241_E 1.181 0.91
117_Y 120_A 1.172 0.90
22_D 199_D 1.171 0.90
220_G 229_R 1.167 0.90
26_A 29_K 1.159 0.90
20_D 23_G 1.156 0.90
86_R 181_A 1.155 0.90
207_A 225_Q 1.149 0.89
22_D 125_K 1.146 0.89
61_G 134_R 1.145 0.89
22_D 62_R 1.142 0.89
55_A 191_R 1.142 0.89
31_H 135_Q 1.135 0.88
78_L 173_T 1.11 0.87
179_I 205_G 1.102 0.86
82_H 199_D 1.099 0.86
167_E 199_D 1.098 0.86
21_L 58_L 1.096 0.86
17_W 52_S 1.094 0.86
114_I 131_L 1.09 0.86
117_Y 139_H 1.087 0.85
119_G 136_A 1.082 0.85
15_Y 192_T 1.081 0.85
203_E 206_F 1.081 0.85
142_A 145_T 1.077 0.85
28_I 35_V 1.071 0.84
175_K 202_D 1.071 0.84
57_A 77_P 1.071 0.84
109_Q 153_I 1.07 0.84
62_R 125_K 1.066 0.84
30_P 135_Q 1.065 0.84
162_G 199_D 1.06 0.83
60_S 64_M 1.054 0.83
131_L 205_G 1.053 0.83
86_R 185_E 1.049 0.82
81_V 127_M 1.049 0.82
232_G 235_D 1.049 0.82
226_A 230_L 1.047 0.82
82_H 203_E 1.043 0.82
22_D 201_T 1.037 0.81
16_A 183_M 1.036 0.81
27_E 233_V 1.036 0.81
20_D 24_T 1.034 0.81
201_T 204_S 1.033 0.81
17_W 194_V 1.033 0.81
151_T 168_I 1.03 0.81
14_K 39_D 1.024 0.80
132_H 165_V 1.024 0.80
175_K 199_D 1.022 0.80
64_M 80_G 1.016 0.80
61_G 199_D 1.014 0.79
218_K 229_R 1.014 0.79
125_K 162_G 1.012 0.79
22_D 82_H 1.006 0.79
196_L 239_W 1.005 0.79
44_G 48_L 1.004 0.78
32_P 134_R 1.002 0.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1u02A10.883599.90.656Contact Map0.602
3pgvA40.887299.80.719Contact Map0.582
3daoA20.879799.80.72Contact Map0.584
3l7yA10.875999.80.724Contact Map0.6
1nrwA10.838399.80.727Contact Map0.579
2b30A40.898599.80.728Contact Map0.558
1l6rA20.79799.80.728Contact Map0.54
1rlmA40.857199.80.733Contact Map0.659
2amyA10.79799.80.734Contact Map0.486
4bndA10.800899.80.736Contact Map0.406
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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