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OPENSEQ.org
SMF - Protein smf
UniProt: P30852 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11604
Length: 374 (362)
Sequences: 1606
Seq/Len: 4.44
SMF
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
150_G 179_H 5.305 1.00
216_S 243_Q 5.035 1.00
172_N 200_D 4.032 1.00
146_R 178_R 3.509 1.00
253_P 256_N 3.215 1.00
144_L 183_A 3.022 1.00
165_A 186_L 2.873 1.00
163_S 186_L 2.855 1.00
98_V 192_A 2.748 1.00
271_I 282_N 2.729 1.00
109_Q 141_T 2.569 1.00
126_G 155_A 2.54 1.00
111_A 222_V 2.463 1.00
98_V 194_V 2.392 1.00
227_A 231_S 2.349 1.00
112_V 130_C 2.329 1.00
317_V 322_T 2.272 1.00
154_K 185_S 2.238 1.00
110_L 140_I 2.219 1.00
73_H 81_F 2.168 1.00
327_V 338_V 2.148 1.00
125_W 250_L 2.138 1.00
151_V 155_A 2.127 1.00
76_P 79_S 2.097 1.00
125_W 254_I 2.096 1.00
129_F 223_L 2.027 1.00
126_G 130_C 2.01 1.00
67_L 72_H 1.994 1.00
25_A 28_V 1.99 1.00
21_M 94_G 1.967 1.00
97_F 198_P 1.925 1.00
197_F 210_R 1.92 1.00
221_G 248_F 1.896 1.00
264_W 268_Q 1.87 1.00
119_S 258_G 1.861 1.00
209_P 235_V 1.858 1.00
126_G 225_V 1.842 1.00
248_F 282_N 1.827 1.00
229_L 260_E 1.804 1.00
112_V 152_A 1.794 1.00
260_E 274_T 1.79 1.00
185_S 189_Q 1.769 1.00
328_A 338_V 1.769 1.00
118_H 123_E 1.732 0.99
334_P 337_E 1.724 0.99
115_S 118_H 1.683 0.99
132_T 276_P 1.67 0.99
127_R 158_Q 1.657 0.99
217_G 243_Q 1.652 0.99
238_R 242_E 1.646 0.99
89_T 243_Q 1.64 0.99
267_K 274_T 1.634 0.99
89_T 92_Y 1.611 0.99
166_V 218_L 1.606 0.99
249_A 266_I 1.595 0.99
16_L 20_D 1.59 0.99
89_T 217_G 1.59 0.99
129_F 250_L 1.578 0.99
183_A 193_L 1.576 0.99
130_C 155_A 1.575 0.99
150_G 182_L 1.563 0.99
177_R 180_A 1.525 0.98
221_G 273_V 1.518 0.98
118_H 148_I 1.515 0.98
225_V 250_L 1.499 0.98
101_E 105_L 1.496 0.98
144_L 165_A 1.496 0.98
328_A 331_A 1.478 0.98
256_N 259_S 1.477 0.98
181_R 184_A 1.473 0.98
223_L 250_L 1.473 0.98
164_I 192_A 1.468 0.98
181_R 185_S 1.465 0.98
110_L 223_L 1.461 0.98
222_V 240_A 1.461 0.98
155_A 159_V 1.461 0.98
166_V 214_I 1.45 0.97
85_Q 88_A 1.448 0.97
111_A 219_S 1.444 0.97
263_H 274_T 1.444 0.97
316_N 331_A 1.441 0.97
328_A 335_V 1.418 0.97
104_A 192_A 1.412 0.97
25_A 29_A 1.411 0.97
249_A 262_P 1.407 0.97
85_Q 220_K 1.403 0.97
131_E 158_Q 1.39 0.96
305_D 348_A 1.384 0.96
130_C 134_A 1.383 0.96
252_G 259_S 1.378 0.96
229_L 264_W 1.373 0.96
197_F 207_N 1.366 0.96
169_N 174_I 1.365 0.96
171_L 193_L 1.363 0.96
121_Y 254_I 1.362 0.96
139_T 162_V 1.356 0.96
216_S 236_T 1.341 0.95
74_L 95_A 1.337 0.95
127_R 154_K 1.324 0.95
174_I 183_A 1.318 0.95
134_A 159_V 1.318 0.95
170_G 203_P 1.298 0.94
233_S 237_A 1.292 0.94
171_L 195_S 1.282 0.94
267_K 278_E 1.27 0.93
323_P 326_V 1.265 0.93
240_A 247_V 1.264 0.93
317_V 351_I 1.237 0.92
14_S 17_Y 1.235 0.92
313_L 341_Q 1.234 0.92
216_S 222_V 1.213 0.91
204_L 207_N 1.212 0.91
73_H 98_V 1.212 0.91
180_A 184_A 1.204 0.91
66_W 70_P 1.195 0.90
139_T 164_I 1.192 0.90
17_Y 20_D 1.191 0.90
72_H 99_E 1.181 0.90
89_T 216_S 1.181 0.90
219_S 222_V 1.179 0.89
101_E 162_V 1.173 0.89
144_L 193_L 1.172 0.89
331_A 338_V 1.171 0.89
125_W 255_G 1.168 0.89
91_D 243_Q 1.168 0.89
144_L 167_L 1.164 0.89
196_E 213_R 1.162 0.89
263_H 272_L 1.16 0.88
322_T 327_V 1.16 0.88
248_F 279_I 1.157 0.88
221_G 282_N 1.147 0.88
259_S 262_P 1.141 0.87
134_A 155_A 1.136 0.87
110_L 133_L 1.135 0.87
35_D 38_V 1.135 0.87
133_L 279_I 1.133 0.87
65_C 68_E 1.126 0.86
63_S 199_L 1.124 0.86
6_I 9_R 1.121 0.86
112_V 223_L 1.116 0.86
171_L 183_A 1.114 0.86
86_L 217_G 1.114 0.86
66_W 72_H 1.11 0.85
185_S 188_E 1.109 0.85
148_I 225_V 1.107 0.85
277_E 281_E 1.104 0.85
216_S 241_L 1.083 0.83
140_I 152_A 1.081 0.83
126_G 151_V 1.08 0.83
302_D 305_D 1.079 0.83
113_V 237_A 1.077 0.83
35_D 39_L 1.069 0.82
130_C 140_I 1.066 0.82
136_R 280_L 1.053 0.81
75_I 98_V 1.05 0.81
167_L 193_L 1.05 0.81
305_D 344_E 1.048 0.81
224_V 237_A 1.045 0.80
153_H 163_S 1.04 0.80
346_E 353_A 1.039 0.80
264_W 267_K 1.039 0.80
138_V 280_L 1.033 0.79
172_N 201_V 1.024 0.78
7_W 21_M 1.023 0.78
144_L 186_L 1.016 0.78
248_F 273_V 1.012 0.77
325_D 356_G 1.012 0.77
133_L 140_I 1.01 0.77
25_A 31_Q 1.007 0.77
121_Y 125_W 1.006 0.77
322_T 330_R 1.006 0.77
221_G 279_I 1.004 0.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3majA10.94121000.197Contact Map0.689
3uqzA30.7621000.343Contact Map0.724
3quaA20.47591000.66Contact Map0.499
1rcuA40.47061000.71Contact Map0.622
2iz6A20.45191000.713Contact Map0.568
1wehA20.40641000.721Contact Map0.482
1wekA60.53211000.722Contact Map0.505
3sbxA80.44921000.733Contact Map0.508
1t35A80.45721000.746Contact Map0.491
2a33A20.50271000.751Contact Map0.449
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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