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OPENSEQ.org

GLUQ - Glutamyl-Q tRNA(Asp) synthetase
UniProt: P27305 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11362
Length: 308 (284)
Sequences: 3193
Seq/Len: 11.24

GLUQ
Paralog alert: 0.57 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: GLUQ SYE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
153_T 159_I 4.414 1.00
101_W 105_Q 4.174 1.00
100_A 104_E 3.917 1.00
113_C 129_C 3.786 1.00
64_P 68_E 2.999 1.00
67_A 87_W 2.991 1.00
68_E 72_R 2.983 1.00
191_H 220_W 2.827 1.00
215_Y 225_Y 2.708 1.00
151_Q 161_H 2.544 1.00
94_A 192_F 2.537 1.00
197_E 224_D 2.529 1.00
87_W 90_Q 2.258 1.00
143_I 217_L 2.235 1.00
157_R 202_A 2.23 1.00
151_Q 159_I 2.219 1.00
112_T 139_A 2.18 1.00
17_I 49_R 2.124 1.00
150_T 164_E 2.072 1.00
216_Q 222_V 2.064 1.00
97_E 101_W 2.057 1.00
103_H 108_S 2.053 1.00
52_V 71_L 2.049 1.00
55_E 186_V 2.017 1.00
99_L 174_H 1.994 1.00
17_I 195_V 1.986 1.00
103_H 141_V 1.939 1.00
212_I 222_V 1.924 1.00
108_S 141_V 1.893 1.00
183_N 211_Q 1.891 1.00
99_L 141_V 1.882 1.00
75_E 80_H 1.86 1.00
42_Q 46_R 1.845 1.00
98_A 192_F 1.821 1.00
28_L 32_S 1.8 1.00
160_I 205_I 1.794 1.00
143_I 213_S 1.77 1.00
75_E 81_W 1.71 1.00
72_R 75_E 1.701 1.00
163_D 166_L 1.7 1.00
114_T 117_R 1.698 1.00
152_F 205_I 1.692 1.00
127_G 130_R 1.68 1.00
133_H 136_P 1.669 1.00
117_R 126_D 1.668 1.00
15_Q 49_R 1.659 1.00
42_Q 197_E 1.642 1.00
94_A 98_A 1.638 1.00
111_C 129_C 1.627 1.00
63_V 66_A 1.626 1.00
98_A 218_F 1.59 1.00
20_F 32_S 1.587 1.00
33_L 77_Y 1.576 1.00
117_R 128_H 1.568 1.00
17_I 194_G 1.565 1.00
93_D 97_E 1.562 1.00
149_V 161_H 1.56 1.00
233_N 243_N 1.558 1.00
95_Y 189_D 1.548 1.00
27_E 69_T 1.547 1.00
121_I 126_D 1.531 1.00
51_L 195_V 1.506 1.00
18_G 39_S 1.499 1.00
155_Q 224_D 1.497 1.00
96_R 174_H 1.49 1.00
110_Y 139_A 1.479 1.00
17_I 83_G 1.475 1.00
149_V 163_D 1.473 1.00
126_D 131_V 1.457 1.00
204_L 207_P 1.451 1.00
44_R 82_D 1.441 1.00
290_L 293_V 1.432 1.00
96_R 100_A 1.421 1.00
171_F 210_R 1.407 0.99
109_Y 170_D 1.399 0.99
153_T 224_D 1.393 0.99
103_H 110_Y 1.392 0.99
156_L 226_I 1.388 0.99
212_I 216_Q 1.381 0.99
91_R 94_A 1.37 0.99
92_H 179_L 1.356 0.99
98_A 188_V 1.353 0.99
145_Q 213_S 1.342 0.99
102_L 107_L 1.335 0.99
110_Y 141_V 1.33 0.99
49_R 83_G 1.308 0.99
101_W 104_E 1.304 0.99
99_L 103_H 1.293 0.99
117_R 129_C 1.288 0.99
276_S 279_Q 1.285 0.99
94_A 97_E 1.268 0.99
117_R 121_I 1.255 0.99
113_C 128_H 1.253 0.99
108_S 173_I 1.243 0.98
183_N 207_P 1.242 0.98
187_V 214_L 1.219 0.98
112_T 137_D 1.214 0.98
148_P 166_L 1.211 0.98
107_L 217_L 1.201 0.98
278_E 286_K 1.196 0.98
71_L 85_V 1.193 0.98
143_I 173_I 1.192 0.98
40_Y 44_R 1.188 0.98
113_C 125_Y 1.172 0.98
289_R 292_A 1.17 0.97
191_H 221_K 1.168 0.97
74_L 79_L 1.154 0.97
93_D 96_R 1.15 0.97
97_E 100_A 1.147 0.97
113_C 121_I 1.145 0.97
50_W 79_L 1.134 0.97
62_E 65_G 1.133 0.97
83_G 86_L 1.131 0.97
204_L 211_Q 1.125 0.97
81_W 84_D 1.124 0.97
98_A 220_W 1.122 0.97
130_R 144_R 1.108 0.96
99_L 108_S 1.101 0.96
71_L 75_E 1.1 0.96
64_P 67_A 1.098 0.96
98_A 101_W 1.092 0.96
35_A 201_G 1.091 0.96
100_A 103_H 1.089 0.96
199_V 226_I 1.088 0.96
226_I 290_L 1.071 0.95
38_G 228_L 1.068 0.95
16_Y 42_Q 1.066 0.95
152_F 212_I 1.054 0.95
112_T 132_L 1.05 0.94
145_Q 171_F 1.049 0.94
62_E 66_A 1.047 0.94
191_H 215_Y 1.046 0.94
226_I 293_V 1.043 0.94
112_T 138_N 1.032 0.94
86_L 193_Q 1.031 0.94
150_T 212_I 1.029 0.94
129_C 132_L 1.021 0.93
155_Q 290_L 1.017 0.93
258_I 277_V 1.016 0.93
187_V 215_Y 1.011 0.93
44_R 80_H 1.006 0.93
121_I 128_H 1.006 0.93
130_R 170_D 1.003 0.93
258_I 280_I 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4griA20.97731000.217Contact Map0.774
2ja2A10.95131000.227Contact Map0.719
1j09A10.93831000.249Contact Map0.757
2cfoA20.93831000.254Contact Map0.846
4g6zA10.97731000.266Contact Map0.756
2o5rA10.95131000.275Contact Map0.726
1nzjA10.96751000.288Contact Map0.738
3al0C10.97081000.289Contact Map0.75
3afhA10.95451000.298Contact Map0.803
4h3sA10.96751000.365Contact Map0.642

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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