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OPENSEQ.org
LPXK - Tetraacyldisaccharide 4'-kinase
UniProt: P27300 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11409
Length: 328 (324)
Sequences: 1090
Seq/Len: 3.36
LPXK
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
44_A 131_V 3.457 1.00
265_Q 271_D 3.044 1.00
80_G 134_I 2.919 1.00
126_V 154_R 2.827 1.00
126_V 129_D 2.747 1.00
51_V 65_V 2.739 1.00
81_V 113_I 2.719 1.00
83_S 110_P 2.695 1.00
162_V 188_L 2.6 1.00
66_V 113_I 2.442 1.00
124_S 129_D 2.428 1.00
124_S 130_A 2.401 1.00
286_E 304_P 2.359 1.00
65_V 145_V 2.352 1.00
56_A 176_L 2.346 1.00
69_V 145_V 2.333 1.00
45_P 135_L 2.25 1.00
64_V 163_V 2.204 1.00
68_L 145_V 2.187 1.00
234_A 244_F 2.157 1.00
69_V 81_V 2.151 1.00
82_V 131_V 2.15 1.00
131_V 144_I 2.056 1.00
33_C 39_K 2.044 1.00
64_V 195_I 2.015 1.00
82_V 130_A 1.961 1.00
17_L 21_W 1.96 1.00
116_R 286_E 1.927 1.00
97_L 106_A 1.874 0.99
41_A 156_A 1.871 0.99
210_L 305_V 1.852 0.99
161_I 193_A 1.844 0.99
79_V 142_Q 1.833 0.99
51_V 68_L 1.792 0.99
236_A 245_F 1.749 0.99
242_P 246_A 1.743 0.99
150_L 191_V 1.732 0.99
95_L 101_T 1.723 0.99
234_A 245_F 1.714 0.99
31_R 153_Y 1.702 0.99
261_L 267_L 1.701 0.99
234_A 248_L 1.675 0.99
164_I 170_F 1.667 0.98
134_I 141_V 1.648 0.98
122_A 134_I 1.645 0.98
152_H 157_R 1.627 0.98
284_M 292_C 1.62 0.98
96_L 122_A 1.601 0.98
34_Y 37_K 1.6 0.98
115_Q 293_R 1.595 0.98
114_Y 121_V 1.565 0.97
157_R 160_E 1.56 0.97
30_I 39_K 1.545 0.97
211_L 308_Q 1.538 0.97
106_A 111_V 1.535 0.97
67_W 71_Q 1.532 0.97
77_I 142_Q 1.53 0.97
267_L 291_K 1.524 0.97
245_F 260_P 1.521 0.97
122_A 133_A 1.506 0.97
150_L 160_E 1.504 0.97
162_V 191_V 1.498 0.96
50_V 160_E 1.488 0.96
131_V 155_L 1.463 0.96
82_V 144_I 1.432 0.95
35_K 153_Y 1.409 0.95
275_L 282_L 1.407 0.95
33_C 38_L 1.396 0.94
80_G 141_V 1.391 0.94
261_L 265_Q 1.389 0.94
43_R 158_D 1.385 0.94
133_A 137_Q 1.377 0.94
72_L 143_I 1.377 0.94
128_S 154_R 1.361 0.93
66_V 117_T 1.34 0.92
80_G 122_A 1.332 0.92
101_T 106_A 1.316 0.92
284_M 300_W 1.315 0.91
149_G 155_L 1.314 0.91
195_I 208_M 1.311 0.91
34_Y 39_K 1.309 0.91
261_L 271_D 1.309 0.91
88_G 125_P 1.299 0.91
165_D 171_G 1.299 0.91
27_S 184_R 1.297 0.91
102_T 105_Q 1.296 0.91
70_E 306_D 1.296 0.91
73_Q 79_V 1.292 0.91
236_A 244_F 1.29 0.90
165_D 168_R 1.285 0.90
24_G 175_W 1.272 0.90
239_G 305_V 1.272 0.90
246_A 249_K 1.272 0.90
42_W 132_K 1.259 0.89
172_N 180_P 1.259 0.89
65_V 81_V 1.246 0.88
79_V 141_V 1.23 0.87
269_H 273_S 1.228 0.87
55_T 164_I 1.221 0.87
79_V 143_I 1.217 0.87
66_V 112_L 1.215 0.87
163_V 197_N 1.213 0.86
97_L 114_Y 1.204 0.86
193_A 316_K 1.203 0.86
34_Y 154_R 1.2 0.86
168_R 240_H 1.194 0.85
30_I 33_C 1.188 0.85
17_L 20_S 1.185 0.85
89_K 104_A 1.183 0.84
183_E 187_R 1.182 0.84
90_A 95_L 1.177 0.84
286_E 302_Y 1.176 0.84
134_I 144_I 1.167 0.83
59_N 163_V 1.165 0.83
259_V 275_L 1.152 0.82
83_S 123_V 1.151 0.82
265_Q 268_N 1.14 0.81
66_V 81_V 1.139 0.81
249_K 258_C 1.13 0.81
42_W 128_S 1.13 0.81
46_V 135_L 1.129 0.81
43_R 156_A 1.129 0.81
212_P 247_T 1.114 0.79
44_A 48_V 1.104 0.78
62_T 112_L 1.101 0.78
183_E 190_S 1.096 0.78
257_K 267_L 1.096 0.78
187_R 190_S 1.094 0.78
15_L 18_P 1.094 0.78
18_P 22_L 1.092 0.77
78_R 142_Q 1.089 0.77
169_R 205_E 1.088 0.77
268_N 271_D 1.087 0.77
231_H 256_E 1.077 0.76
150_L 163_V 1.074 0.76
50_V 157_R 1.066 0.75
313_E 317_L 1.064 0.75
88_G 239_G 1.061 0.74
69_V 119_A 1.06 0.74
75_R 315_A 1.057 0.74
68_L 103_T 1.051 0.73
174_W 178_A 1.05 0.73
22_L 26_V 1.047 0.73
237_G 284_M 1.043 0.73
82_V 146_T 1.041 0.72
32_L 36_L 1.041 0.72
284_M 291_K 1.036 0.72
50_V 146_T 1.032 0.72
113_I 117_T 1.031 0.71
128_S 131_V 1.028 0.71
70_E 116_R 1.027 0.71
24_G 184_R 1.022 0.70
51_V 161_I 1.021 0.70
62_T 113_I 1.021 0.70
31_R 190_S 1.011 0.69
29_A 38_L 1.007 0.69
49_V 159_V 1.004 0.68
262_A 265_Q 1 0.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ehxA10.91161000.162Contact Map0.733
1xjcA10.484896.50.935Contact Map0.261
3q9lA20.722695.30.941Contact Map0.218
2ynmA20.820194.90.943Contact Map0.247
3ea0A20.701294.80.943Contact Map0.246
4dzzA20.615994.80.943Contact Map0.306
2afhE20.783594.50.944Contact Map0.25
3kjhA10.682994.30.944Contact Map0.226
2ozeA10.835494.30.944Contact Map0.186
3ug7A40.8902940.945Contact Map0.201
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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