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OPENSEQ.org
SCPA - Methylmalonyl-CoA mutase
UniProt: P27253 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11444
Length: 714 (705)
Sequences: 783
Seq/Len: 1.11
SCPA
Paralog alert: 0.37 [within 20: 0.21] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
494_D 498_T 4.45 1.00
681_A 685_E 4.444 1.00
256_I 301_V 3.972 1.00
299_E 410_R 3.757 1.00
487_R 491_T 3.443 1.00
629_R 633_E 3.399 1.00
516_A 520_N 3.256 1.00
493_D 496_A 3.216 1.00
265_K 268_D 3.044 1.00
257_K 417_D 3.007 1.00
177_T 180_K 2.879 1.00
168_I 519_V 2.829 1.00
134_T 488_I 2.719 1.00
652_I 671_A 2.685 1.00
408_Q 411_A 2.667 1.00
504_L 535_L 2.53 0.99
284_F 398_I 2.477 0.99
548_C 617_L 2.43 0.99
410_R 414_Q 2.395 0.99
277_F 290_L 2.393 0.99
295_Y 406_V 2.319 0.99
442_E 451_R 2.293 0.99
482_I 486_E 2.267 0.99
265_K 307_Q 2.228 0.98
658_A 661_K 2.218 0.98
36_K 43_D 2.216 0.98
403_D 407_K 2.191 0.98
85_K 480_E 2.167 0.98
284_F 397_Y 2.159 0.98
240_N 438_A 2.141 0.98
400_S 404_Q 2.133 0.98
505_T 537_V 2.123 0.98
604_I 608_Y 2.112 0.98
625_E 658_A 2.085 0.97
161_L 535_L 2.07 0.97
495_A 499_A 2.042 0.97
167_Y 171_A 2.021 0.97
486_E 490_A 2.01 0.96
214_I 259_A 2.007 0.96
658_A 662_W 1.989 0.96
172_E 523_R 1.974 0.96
270_A 301_V 1.932 0.95
483_A 487_R 1.931 0.95
148_D 180_K 1.931 0.95
502_N 506_H 1.911 0.95
461_L 464_E 1.91 0.95
40_T 43_D 1.89 0.94
496_A 520_N 1.882 0.94
217_C 226_T 1.878 0.94
639_V 655_L 1.872 0.94
260_I 266_I 1.863 0.94
245_V 405_I 1.844 0.93
573_Q 707_N 1.84 0.93
535_L 539_F 1.831 0.93
148_D 176_V 1.826 0.93
139_K 173_E 1.825 0.93
575_E 584_R 1.82 0.93
211_A 258_A 1.805 0.93
166_F 528_L 1.8 0.92
119_P 625_E 1.774 0.92
27_H 35_I 1.751 0.91
404_Q 408_Q 1.751 0.91
407_K 411_A 1.743 0.91
476_M 480_E 1.738 0.91
277_F 293_A 1.733 0.90
671_A 688_V 1.724 0.90
298_S 302_S 1.705 0.89
508_A 535_L 1.68 0.88
533_D 537_V 1.674 0.88
331_Y 335_I 1.673 0.88
424_K 427_E 1.672 0.88
136_E 488_I 1.664 0.88
169_V 523_R 1.659 0.88
572_A 576_Q 1.655 0.87
570_I 703_R 1.651 0.87
25_L 37_P 1.627 0.86
496_A 524_V 1.599 0.85
445_L 451_R 1.587 0.84
573_Q 710_S 1.556 0.83
361_L 677_P 1.554 0.83
93_R 366_D 1.546 0.82
166_F 522_A 1.543 0.82
28_Q 34_A 1.542 0.82
87_S 91_Y 1.535 0.82
522_A 531_I 1.528 0.81
36_K 39_Y 1.519 0.81
31_E 285_M 1.505 0.80
580_D 710_S 1.505 0.80
507_A 517_A 1.494 0.79
520_N 524_V 1.492 0.79
345_T 385_L 1.485 0.78
479_N 483_A 1.472 0.78
509_Q 537_V 1.469 0.77
506_H 509_Q 1.464 0.77
604_I 670_V 1.462 0.77
500_A 524_V 1.457 0.77
379_I 482_I 1.454 0.76
656_V 686_R 1.453 0.76
215_A 219_G 1.453 0.76
116_S 131_A 1.444 0.76
503_A 517_A 1.444 0.76
506_H 510_H 1.443 0.76
341_A 352_L 1.44 0.75
247_F 430_L 1.436 0.75
604_I 701_S 1.43 0.75
495_A 498_T 1.428 0.75
518_A 531_I 1.426 0.74
349_T 352_L 1.42 0.74
680_Y 693_G 1.415 0.74
452_V 458_K 1.406 0.73
139_K 525_R 1.392 0.72
486_E 489_R 1.375 0.71
570_I 699_L 1.372 0.70
334_V 357_F 1.367 0.70
44_L 47_L 1.364 0.70
339_I 343_A 1.361 0.69
489_R 527_T 1.359 0.69
584_R 616_D 1.352 0.69
483_A 486_E 1.348 0.68
469_V 677_P 1.346 0.68
116_S 133_D 1.343 0.68
573_Q 703_R 1.34 0.68
625_E 654_E 1.335 0.67
415_Q 434_M 1.332 0.67
94_N 102_L 1.323 0.66
277_F 318_C 1.316 0.66
211_A 215_A 1.313 0.65
39_Y 43_D 1.311 0.65
75_I 373_R 1.307 0.65
588_L 636_V 1.306 0.65
244_Q 289_M 1.305 0.65
557_Y 699_L 1.301 0.64
498_T 502_N 1.286 0.63
302_S 312_L 1.285 0.63
243_Q 434_M 1.282 0.63
391_P 398_I 1.279 0.62
704_D 708_L 1.278 0.62
499_A 503_A 1.277 0.62
586_R 614_D 1.277 0.62
641_A 671_A 1.276 0.62
568_D 571_V 1.276 0.62
216_W 519_V 1.275 0.62
52_T 60_V 1.271 0.62
249_L 300_A 1.269 0.62
616_D 634_N 1.264 0.61
498_T 537_V 1.262 0.61
140_V 484_S 1.262 0.61
245_V 409_A 1.261 0.61
680_Y 691_I 1.26 0.61
25_L 38_L 1.26 0.61
589_I 608_Y 1.253 0.60
549_V 681_A 1.253 0.60
411_A 483_A 1.248 0.60
629_R 662_W 1.227 0.58
670_V 701_S 1.226 0.58
521_A 526_A 1.226 0.58
480_E 483_A 1.226 0.58
136_E 348_G 1.225 0.57
649_K 682_F 1.224 0.57
346_L 392_L 1.224 0.57
288_A 401_L 1.223 0.57
136_E 525_R 1.222 0.57
42_A 45_D 1.222 0.57
53_L 56_L 1.221 0.57
234_M 435_I 1.22 0.57
178_P 220_N 1.216 0.57
700_D 711_Q 1.214 0.56
486_E 502_N 1.209 0.56
293_A 460_K 1.209 0.56
495_A 503_A 1.209 0.56
253_I 305_G 1.207 0.56
104_V 132_I 1.207 0.56
356_A 611_L 1.205 0.56
507_A 512_E 1.204 0.55
26_V 34_A 1.203 0.55
327_E 601_A 1.2 0.55
279_I 286_N 1.193 0.54
684_Q 691_I 1.193 0.54
298_S 312_L 1.191 0.54
168_I 216_W 1.183 0.53
488_I 491_T 1.183 0.53
657_E 661_K 1.175 0.53
100_K 150_M 1.175 0.53
704_D 707_N 1.175 0.53
219_G 268_D 1.168 0.52
135_V 488_I 1.166 0.52
171_A 181_L 1.165 0.52
283_L 574_T 1.164 0.52
35_I 397_Y 1.161 0.51
331_Y 357_F 1.159 0.51
681_A 684_Q 1.158 0.51
614_D 630_L 1.156 0.51
257_K 261_S 1.156 0.51
628_A 658_A 1.156 0.51
703_R 708_L 1.154 0.51
699_L 703_R 1.154 0.51
346_L 398_I 1.152 0.51
214_I 262_A 1.148 0.50
172_E 178_P 1.148 0.50
499_A 502_N 1.145 0.50
566_E 700_D 1.142 0.50
357_F 467_T 1.139 0.49
219_G 516_A 1.137 0.49
505_T 538_A 1.135 0.49
433_R 549_V 1.132 0.49
557_Y 704_D 1.129 0.48
136_E 139_K 1.126 0.48
249_L 410_R 1.125 0.48
682_F 685_E 1.124 0.48
472_I 477_V 1.122 0.48
700_D 704_D 1.121 0.48
546_S 688_V 1.121 0.48
482_I 489_R 1.121 0.48
338_T 348_G 1.12 0.47
334_V 371_I 1.117 0.47
75_I 377_I 1.116 0.47
476_M 569_A 1.113 0.47
144_Q 524_V 1.111 0.47
503_A 519_V 1.11 0.47
563_S 568_D 1.108 0.46
377_I 423_A 1.105 0.46
437_E 441_R 1.103 0.46
345_T 383_S 1.1 0.46
256_I 260_I 1.097 0.45
342_L 346_L 1.096 0.45
234_M 251_D 1.092 0.45
89_A 93_R 1.089 0.45
59_Y 307_Q 1.089 0.45
624_P 651_L 1.089 0.45
178_P 520_N 1.089 0.45
497_V 526_A 1.088 0.44
502_N 537_V 1.087 0.44
392_L 398_I 1.086 0.44
30_A 445_L 1.086 0.44
583_R 635_D 1.085 0.44
190_L 423_A 1.082 0.44
242_V 408_Q 1.082 0.44
536_E 541_R 1.081 0.44
410_R 413_I 1.081 0.44
479_N 486_E 1.081 0.44
592_M 655_L 1.077 0.43
346_L 385_L 1.077 0.43
419_A 430_L 1.074 0.43
496_A 575_E 1.073 0.43
641_A 652_I 1.073 0.43
568_D 572_A 1.072 0.43
641_A 644_L 1.071 0.43
469_V 678_Q 1.071 0.43
632_V 662_W 1.069 0.43
505_T 509_Q 1.067 0.42
287_V 712_H 1.063 0.42
616_D 635_D 1.063 0.42
7_W 17_R 1.063 0.42
512_E 516_A 1.062 0.42
284_F 346_L 1.059 0.42
450_K 589_I 1.058 0.42
471_E 649_K 1.058 0.42
94_N 369_A 1.057 0.42
6_E 9_Q 1.057 0.42
335_I 378_I 1.057 0.42
204_K 424_K 1.056 0.41
588_L 627_I 1.049 0.41
708_L 711_Q 1.047 0.41
682_F 686_R 1.045 0.40
587_I 688_V 1.041 0.40
7_W 15_L 1.039 0.40
490_A 517_A 1.039 0.40
253_I 306_A 1.038 0.40
507_A 510_H 1.038 0.40
260_I 469_V 1.038 0.40
638_V 670_V 1.038 0.40
7_W 25_L 1.037 0.40
241_C 405_I 1.035 0.40
285_M 397_Y 1.034 0.39
161_L 167_Y 1.033 0.39
707_N 710_S 1.033 0.39
183_G 222_P 1.032 0.39
348_G 697_P 1.031 0.39
567_F 705_V 1.031 0.39
586_R 635_D 1.03 0.39
36_K 459_Y 1.029 0.39
487_R 490_A 1.028 0.39
554_A 562_K 1.028 0.39
243_Q 412_I 1.024 0.39
506_H 537_V 1.021 0.38
506_H 712_H 1.021 0.38
660_K 665_E 1.02 0.38
383_S 484_S 1.02 0.38
283_L 345_T 1.018 0.38
8_Q 12_N 1.017 0.38
571_V 712_H 1.016 0.38
249_L 296_L 1.012 0.37
498_T 527_T 1.012 0.37
303_G 306_A 1.01 0.37
299_E 414_Q 1.01 0.37
116_S 481_Q 1.008 0.37
33_I 285_M 1.008 0.37
704_D 711_Q 1.007 0.37
504_L 625_E 1.006 0.37
284_F 392_L 1.006 0.37
341_A 379_I 1.005 0.37
454_V 519_V 1.003 0.37
704_D 712_H 1.001 0.36
503_A 506_H 1 0.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2xijA10.98881000.154Contact Map0.615
1reqA20.9861000.157Contact Map0.595
1reqB20.83471000.268Contact Map0.543
3kp1A40.90341000.495Contact Map0.28
1ccwB20.63591000.864Contact Map0.322
3ezxA10.288599.30.943Contact Map0.364
3bulA10.308199.20.946Contact Map0.497
1xrsB10.319399.20.946Contact Map0.37
4jgiA20.284398.90.95Contact Map0.489
1y80A10.281598.90.951Contact Map0.476
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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