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OPENSEQ.org
WAAU - Lipopolysaccharide 1,2-N-acetylglucosaminetransferase
UniProt: P27242 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11423
Length: 357 (311)
Sequences: 2166
Seq/Len: 6.96
WAAU
Paralog alert: 0.74 [within 20: 0.42] - ratio of genomes with paralogs
Cluster includes: RFAC RFAF RFAQ WAAU
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
73_T 116_F 4.648 1.00
212_I 280_S 4.154 1.00
331_S 335_T 3.905 1.00
282_F 348_V 3.883 1.00
42_S 71_K 3.174 1.00
235_E 345_T 3.037 1.00
43_C 70_V 2.87 1.00
228_Q 341_T 2.829 1.00
213_I 233_Y 2.77 1.00
92_E 114_L 2.705 1.00
229_I 286_V 2.598 1.00
291_V 303_A 2.56 1.00
212_I 277_T 2.549 1.00
273_T 290_L 2.541 1.00
66_Y 91_F 2.491 1.00
232_I 345_T 2.33 1.00
232_I 284_I 2.305 1.00
284_I 348_V 2.301 1.00
269_E 272_Y 2.295 1.00
224_L 344_L 2.251 1.00
71_K 91_F 2.229 1.00
71_K 92_E 2.217 1.00
249_G 266_P 2.145 1.00
55_L 84_L 2.123 1.00
212_I 248_T 2.064 1.00
225_T 228_Q 2.023 1.00
235_E 342_E 1.991 1.00
211_V 236_V 1.97 1.00
210_I 279_Y 1.911 1.00
200_K 272_Y 1.906 1.00
73_T 91_F 1.903 1.00
197_V 271_I 1.851 1.00
210_I 280_S 1.834 1.00
209_R 281_D 1.833 1.00
44_L 75_L 1.814 1.00
73_T 92_E 1.78 1.00
285_S 291_V 1.772 1.00
231_V 234_Q 1.73 1.00
239_H 349_K 1.723 1.00
73_T 94_C 1.685 1.00
224_L 228_Q 1.673 1.00
66_Y 72_I 1.651 1.00
61_I 123_F 1.644 1.00
176_L 182_E 1.609 1.00
42_S 114_L 1.598 1.00
323_H 326_S 1.59 1.00
228_Q 231_V 1.569 1.00
202_K 279_Y 1.553 1.00
210_I 281_D 1.543 0.99
81_G 85_S 1.53 0.99
198_E 278_K 1.525 0.99
210_I 246_I 1.507 0.99
211_V 282_F 1.502 0.99
235_E 239_H 1.478 0.99
248_T 273_T 1.471 0.99
166_E 174_E 1.468 0.99
230_K 234_Q 1.465 0.99
274_V 293_I 1.462 0.99
58_L 123_F 1.433 0.99
263_E 266_P 1.43 0.99
55_L 74_L 1.418 0.99
45_I 62_Y 1.402 0.99
309_R 314_P 1.396 0.99
142_Y 160_H 1.396 0.99
342_E 346_N 1.386 0.99
42_S 73_T 1.384 0.99
118_I 144_L 1.381 0.99
304_F 339_I 1.366 0.98
82_E 85_S 1.348 0.98
197_V 272_Y 1.331 0.98
224_L 229_I 1.33 0.98
336_V 339_I 1.327 0.98
249_G 263_E 1.314 0.98
214_N 285_S 1.306 0.98
212_I 276_L 1.305 0.98
214_N 248_T 1.294 0.98
76_T 93_F 1.293 0.98
74_L 84_L 1.292 0.98
277_T 297_Y 1.276 0.97
195_V 199_D 1.273 0.97
211_V 243_Y 1.273 0.97
86_N 271_I 1.272 0.97
143_I 158_H 1.27 0.97
234_Q 238_T 1.262 0.97
231_V 342_E 1.262 0.97
232_I 235_E 1.262 0.97
222_C 287_D 1.257 0.97
236_V 345_T 1.257 0.97
73_T 114_L 1.251 0.97
340_D 343_T 1.242 0.97
285_S 303_A 1.228 0.96
282_F 302_L 1.222 0.96
174_E 177_K 1.22 0.96
243_Y 281_D 1.217 0.96
61_I 176_L 1.206 0.96
283_V 299_K 1.205 0.96
223_R 286_V 1.197 0.96
232_I 341_T 1.195 0.96
302_L 347_S 1.194 0.96
66_Y 70_V 1.188 0.95
233_Y 247_F 1.185 0.95
44_L 116_F 1.185 0.95
348_V 352_S 1.181 0.95
287_D 305_Y 1.175 0.95
47_H 51_K 1.172 0.95
215_P 247_F 1.161 0.95
46_I 75_L 1.159 0.95
345_T 349_K 1.157 0.94
217_G 223_R 1.156 0.94
216_L 253_D 1.152 0.94
224_L 341_T 1.143 0.94
343_T 347_S 1.142 0.94
334_Y 338_D 1.14 0.94
237_K 261_E 1.13 0.94
74_L 90_I 1.127 0.93
291_V 305_Y 1.126 0.93
55_L 80_G 1.126 0.93
347_S 350_R 1.124 0.93
136_S 143_I 1.124 0.93
210_I 244_R 1.121 0.93
51_K 57_V 1.12 0.93
228_Q 340_D 1.118 0.93
225_T 337_K 1.114 0.93
108_C 112_R 1.111 0.93
78_R 97_E 1.108 0.93
214_N 288_T 1.107 0.93
236_V 348_V 1.104 0.92
52_L 80_G 1.101 0.92
283_V 294_A 1.101 0.92
59_S 87_N 1.096 0.92
309_R 315_S 1.092 0.92
194_P 197_V 1.089 0.92
63_R 67_S 1.088 0.92
57_V 319_W 1.074 0.91
213_I 284_I 1.061 0.90
231_V 341_T 1.061 0.90
211_V 352_S 1.054 0.90
284_I 302_L 1.053 0.90
235_E 341_T 1.048 0.90
78_R 81_G 1.046 0.90
81_G 93_F 1.045 0.89
224_L 232_I 1.043 0.89
43_C 72_I 1.042 0.89
248_T 280_S 1.037 0.89
57_V 74_L 1.036 0.89
109_K 113_D 1.035 0.89
51_K 55_L 1.028 0.88
216_L 286_V 1.026 0.88
105_L 109_K 1.02 0.88
62_Y 74_L 1.015 0.88
249_G 268_D 1.015 0.88
264_T 268_D 1.013 0.87
46_I 119_V 1 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2gt1A20.84031000.386Contact Map0.789
3tovA20.86271000.39Contact Map0.79
1pswA10.84311000.401Contact Map0.763
2yjnA10.885298.90.849Contact Map0.578
3ot5A40.890898.80.855Contact Map0.672
4fzrA10.859998.80.856Contact Map0.649
1rrvA20.820798.60.866Contact Map0.636
3h4tA10.806798.50.868Contact Map0.61
3otgA10.859998.50.868Contact Map0.618
3tsaA20.831998.50.87Contact Map0.556
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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