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OPENSEQ.org
UBIC - Chorismate--pyruvate lyase
UniProt: P26602 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11369
Length: 165 (165)
Sequences: 373
Seq/Len: 2.26
UBIC
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
127_R 143_S 2.33 1.00
53_E 75_W 2.057 0.99
131_E 142_R 2.017 0.99
35_M 89_L 1.929 0.99
25_L 139_W 1.778 0.98
83_A 88_W 1.766 0.98
92_R 155_T 1.762 0.98
40_E 117_R 1.733 0.97
48_V 81_L 1.702 0.97
114_P 117_R 1.612 0.96
62_P 66_P 1.601 0.95
62_P 92_R 1.57 0.95
118_Y 125_L 1.516 0.93
145_L 157_L 1.447 0.91
43_G 83_A 1.437 0.91
100_L 107_L 1.429 0.90
46_V 89_L 1.405 0.89
118_Y 130_I 1.4 0.89
146_R 151_P 1.366 0.87
125_L 155_T 1.347 0.86
7_T 10_R 1.341 0.86
34_S 81_L 1.336 0.86
5_A 8_Q 1.334 0.86
116_G 120_F 1.331 0.85
162_S 165_Y 1.329 0.85
6_L 10_R 1.328 0.85
47_S 85_G 1.323 0.85
58_Q 74_Y 1.317 0.85
99_T 147_L 1.309 0.84
127_R 130_I 1.301 0.84
59_N 93_T 1.261 0.81
34_S 116_G 1.252 0.80
121_T 130_I 1.251 0.80
3_H 7_T 1.247 0.80
43_G 84_D 1.244 0.80
37_K 40_E 1.223 0.78
31_L 145_L 1.205 0.77
75_W 107_L 1.204 0.77
46_V 81_L 1.203 0.76
36_T 119_L 1.203 0.76
128_D 145_L 1.198 0.76
93_T 128_D 1.197 0.76
35_M 91_G 1.195 0.76
9_L 157_L 1.194 0.76
100_L 139_W 1.192 0.76
91_G 155_T 1.191 0.75
96_P 99_T 1.182 0.75
83_A 120_F 1.182 0.75
75_W 78_E 1.176 0.74
21_L 113_T 1.176 0.74
99_T 151_P 1.161 0.73
110_L 139_W 1.155 0.72
17_E 25_L 1.149 0.72
23_P 44_K 1.141 0.71
2_S 5_A 1.14 0.71
31_L 38_R 1.13 0.70
93_T 152_L 1.128 0.70
92_R 115_L 1.126 0.69
21_L 130_I 1.122 0.69
43_G 76_L 1.12 0.69
58_Q 65_L 1.119 0.69
89_L 154_L 1.117 0.69
4_P 7_T 1.114 0.68
4_P 8_Q 1.112 0.68
43_G 152_L 1.107 0.68
130_I 140_G 1.104 0.67
89_L 93_T 1.103 0.67
3_H 8_Q 1.096 0.66
87_P 159_L 1.094 0.66
90_A 138_L 1.089 0.66
22_D 25_L 1.085 0.65
78_E 92_R 1.081 0.65
140_G 143_S 1.081 0.65
27_D 38_R 1.079 0.65
37_K 80_L 1.079 0.65
3_H 6_L 1.077 0.64
41_Q 44_K 1.076 0.64
111_G 128_D 1.066 0.63
115_L 142_R 1.066 0.63
115_L 154_L 1.054 0.62
94_V 151_P 1.051 0.62
52_R 161_A 1.048 0.61
49_T 80_L 1.043 0.61
147_L 151_P 1.034 0.60
35_M 155_T 1.024 0.59
81_L 111_G 1.024 0.59
93_T 133_G 1.019 0.58
7_T 164_L 1.014 0.58
6_L 9_L 1.013 0.57
2_S 7_T 1.008 0.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1tt8A10.99391000.162Contact Map0.404
2nwiA60.89091000.294Contact Map0.393
2pkhA80.757696.60.865Contact Map0.32
3hfiA10.848596.60.865Contact Map0.262
2ikkA20.890996.40.869Contact Map0.255
2fa1A20.824296.30.87Contact Map0.167
3cnvA40.806196.20.871Contact Map0.261
2p19A30.7515960.873Contact Map0.266
3ddvA40.739495.70.876Contact Map0.303
2ooiA20.824295.30.879Contact Map0.323
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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