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OPENSEQ.org

YFFB - Protein YffB
UniProt: P24178 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11147
Length: 118 (115)
Sequences: 2338
Seq/Len: 20.33

YFFB
Paralog alert: 0.78 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: ARSC YFFB YFGD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
31_D 34_V 3.569 1.00
39_S 81_A 3.323 1.00
83_M 90_I 2.86 1.00
21_E 27_Y 2.609 1.00
75_D 78_S 2.443 1.00
38_D 41_L 2.438 1.00
44_D 48_E 2.216 1.00
39_S 43_N 2.108 1.00
66_D 69_T 2.074 1.00
46_I 80_A 2.032 1.00
4_L 95_L 1.786 1.00
81_A 85_E 1.74 1.00
6_G 29_F 1.74 1.00
49_L 54_L 1.664 1.00
60_T 64_K 1.658 1.00
3_T 28_R 1.657 1.00
37_L 90_I 1.647 1.00
33_R 88_A 1.642 1.00
110_S 113_Q 1.573 1.00
74_T 82_L 1.553 1.00
30_H 41_L 1.546 1.00
46_I 54_L 1.523 1.00
43_N 80_A 1.507 1.00
97_V 101_P 1.485 1.00
21_E 26_D 1.438 1.00
19_W 23_N 1.428 1.00
4_L 17_R 1.423 1.00
12_T 15_K 1.41 1.00
18_R 22_A 1.399 0.99
39_S 80_A 1.394 0.99
61_T 86_M 1.347 0.99
49_L 94_L 1.336 0.99
95_L 111_Y 1.33 0.99
48_E 102_M 1.317 0.99
54_L 94_L 1.289 0.99
17_R 29_F 1.289 0.99
55_L 83_M 1.28 0.99
30_H 35_D 1.273 0.99
45_F 94_L 1.249 0.99
103_L 114_F 1.196 0.98
45_F 96_C 1.192 0.98
67_E 70_R 1.181 0.98
51_W 76_A 1.178 0.98
41_L 44_D 1.17 0.97
10_C 92_R 1.148 0.97
7_I 13_I 1.125 0.97
108_D 112_Q 1.125 0.97
40_E 43_N 1.123 0.97
61_T 64_K 1.123 0.97
43_N 77_A 1.118 0.96
41_L 96_C 1.116 0.96
52_E 62_W 1.085 0.96
42_L 80_A 1.056 0.95
19_W 112_Q 1.054 0.95
59_G 88_A 1.051 0.94
19_W 106_F 1.049 0.94
30_H 36_G 1.045 0.94
46_I 50_G 1.03 0.94
57_T 63_R 1.02 0.93
13_I 32_Y 1.018 0.93
39_S 84_T 1.013 0.93
4_L 13_I 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3fz4A10.96611000.156Contact Map0.698
2m46A10.98311000.159Contact Map0.705
1rw1A10.96611000.162Contact Map0.773
3gkxA20.96611000.168Contact Map0.806
2kokA10.97461000.17Contact Map0.48
1s3cA10.97461000.175Contact Map0.81
1z3eA10.97461000.182Contact Map0.805
3f0iA20.94921000.186Contact Map0.818
3l78A10.97461000.192Contact Map0.665
3rdwA20.95761000.196Contact Map0.807

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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