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OPENSEQ.org
AES - Acetyl esterase
UniProt: P23872 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11101
Length: 319 (307)
Sequences: 3546
Seq/Len: 11.55
AES
Paralog alert: 0.52 [within 20: 0.06] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
124_T 137_E 3.775 1.00
87_L 162_A 3.415 1.00
90_L 138_I 3.396 1.00
269_R 286_L 3.332 1.00
246_D 249_R 3.05 1.00
148_Q 151_D 2.883 1.00
86_T 154_I 2.78 1.00
172_L 271_L 2.68 1.00
275_L 280_Q 2.668 1.00
104_D 108_R 2.595 1.00
155_N 158_R 2.481 1.00
129_A 133_Q 2.414 1.00
205_T 266_D 2.362 1.00
287_Y 310_D 2.344 1.00
68_K 140_A 2.315 1.00
95_F 169_M 2.275 1.00
195_Y 198_Y 2.24 1.00
45_T 99_N 2.174 1.00
256_I 272_Y 2.154 1.00
177_W 181_K 2.151 1.00
285_K 310_D 2.124 1.00
272_Y 282_C 2.123 1.00
103_H 164_D 2.109 1.00
111_A 118_V 2.108 1.00
254_C 275_L 2.1 1.00
258_G 268_S 2.015 1.00
136_E 177_W 1.979 1.00
272_Y 284_F 1.961 1.00
119_I 145_F 1.944 1.00
76_L 119_I 1.931 1.00
113_Y 309_R 1.912 1.00
86_T 145_F 1.895 1.00
190_G 195_Y 1.894 1.00
100_L 122_D 1.87 1.00
139_V 178_L 1.862 1.00
139_V 177_W 1.862 1.00
160_G 315_F 1.834 1.00
208_L 265_L 1.823 1.00
258_G 286_L 1.808 1.00
160_G 190_G 1.803 1.00
273_Q 277_A 1.773 1.00
258_G 284_F 1.765 1.00
87_L 116_C 1.745 1.00
144_Y 148_Q 1.713 1.00
88_F 141_A 1.71 1.00
107_M 118_V 1.697 1.00
273_Q 276_A 1.695 1.00
89_Y 162_A 1.693 1.00
192_L 195_Y 1.683 1.00
36_T 39_E 1.676 1.00
16_E 302_K 1.665 1.00
134_A 228_Y 1.64 1.00
135_I 173_A 1.632 1.00
77_F 104_D 1.616 1.00
269_R 284_F 1.596 1.00
256_I 268_S 1.595 1.00
88_F 142_C 1.563 1.00
123_Y 166_A 1.559 1.00
131_F 228_Y 1.556 1.00
75_R 104_D 1.554 1.00
121_I 141_A 1.528 1.00
190_G 271_L 1.522 1.00
142_C 178_L 1.518 1.00
258_G 269_R 1.518 1.00
117_T 154_I 1.487 1.00
177_W 239_Y 1.481 1.00
124_T 129_A 1.466 1.00
63_Y 74_T 1.463 1.00
191_V 195_Y 1.458 1.00
89_Y 103_H 1.456 1.00
193_L 196_G 1.417 1.00
131_F 237_S 1.407 0.99
260_E 288_P 1.403 0.99
266_D 269_R 1.376 0.99
74_T 141_A 1.372 0.99
74_T 119_I 1.367 0.99
142_C 174_S 1.365 0.99
255_F 314_F 1.36 0.99
166_A 170_L 1.36 0.99
75_R 100_L 1.348 0.99
85_A 155_N 1.346 0.99
130_R 133_Q 1.335 0.99
190_G 196_G 1.334 0.99
37_I 41_R 1.332 0.99
113_Y 312_A 1.327 0.99
139_V 143_C 1.319 0.99
180_D 239_Y 1.315 0.99
78_C 117_T 1.312 0.99
86_T 119_I 1.287 0.99
76_L 117_T 1.274 0.99
18_K 22_N 1.266 0.99
229_L 240_Y 1.263 0.99
62_A 75_R 1.256 0.99
138_I 174_S 1.246 0.98
133_Q 137_E 1.237 0.98
260_E 289_G 1.236 0.98
176_L 239_Y 1.235 0.98
247_L 274_T 1.22 0.98
259_A 294_F 1.216 0.98
192_L 196_G 1.213 0.98
90_L 121_I 1.201 0.98
114_S 312_A 1.197 0.98
254_C 271_L 1.196 0.98
88_F 174_S 1.184 0.98
143_C 147_Q 1.18 0.98
109_L 113_Y 1.175 0.98
73_E 122_D 1.169 0.97
88_F 145_F 1.169 0.97
142_C 188_V 1.168 0.97
39_E 42_Q 1.167 0.97
89_Y 164_D 1.165 0.97
287_Y 307_A 1.159 0.97
176_L 179_R 1.147 0.97
67_T 70_G 1.146 0.97
139_V 181_K 1.144 0.97
205_T 209_L 1.141 0.97
169_M 228_Y 1.139 0.97
276_A 282_C 1.139 0.97
41_R 128_E 1.132 0.97
223_M 227_A 1.124 0.97
175_A 191_V 1.115 0.96
287_Y 294_F 1.11 0.96
314_F 318_Q 1.106 0.96
265_L 269_R 1.1 0.96
195_Y 199_G 1.097 0.96
169_M 173_A 1.095 0.96
161_F 171_A 1.095 0.96
265_L 286_L 1.087 0.96
107_M 120_G 1.079 0.95
230_S 235_R 1.077 0.95
309_R 313_Q 1.077 0.95
84_P 117_T 1.073 0.95
90_L 174_S 1.071 0.95
294_F 304_A 1.069 0.95
185_C 188_V 1.056 0.95
131_F 240_Y 1.048 0.94
131_F 239_Y 1.039 0.94
301_M 304_A 1.038 0.94
196_G 199_G 1.035 0.94
206_R 221_L 1.035 0.94
172_L 254_C 1.032 0.94
190_G 198_Y 1.032 0.94
130_R 230_S 1.027 0.94
191_V 196_G 1.019 0.93
290_T 303_T 1.006 0.93
95_F 197_L 1.002 0.92
229_L 235_R 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2hm7A10.94981000.34Contact Map0.765
1lzlA10.94981000.342Contact Map0.774
2wirA20.94981000.349Contact Map0.831
2c7bA20.94361000.37Contact Map0.827
3ga7A111000.374Contact Map0.772
3ainA40.9531000.385Contact Map0.769
3qh4A10.95921000.406Contact Map0.754
1jjiA40.95921000.412Contact Map0.844
3fakA10.94981000.425Contact Map0.791
2o7rA10.95921000.435Contact Map0.676
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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