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OPENSEQ.org
KITH - Thymidine kinase
UniProt: P23331 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10994
Length: 205 (191)
Sequences: 1004
Seq/Len: 5.26
KITH
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
147_C 182_C 3.412 1.00
182_C 185_H 2.85 1.00
35_V 49_V 2.631 1.00
155_L 181_V 2.426 1.00
3_Q 137_K 2.309 1.00
147_C 185_H 2.306 1.00
23_S 33_T 2.064 1.00
48_K 56_S 2.029 1.00
100_L 113_C 1.885 1.00
89_C 113_C 1.873 1.00
67_S 70_D 1.847 1.00
18_A 21_Q 1.796 1.00
171_V 177_R 1.781 1.00
27_Q 57_S 1.743 1.00
39_E 63_N 1.704 1.00
45_G 48_K 1.684 1.00
9_S 13_A 1.644 0.99
117_R 140_E 1.637 0.99
95_Q 99_E 1.62 0.99
17_T 21_Q 1.617 0.99
36_Y 71_E 1.579 0.99
105_D 183_R 1.562 0.99
43_R 173_G 1.561 0.99
89_C 96_Q 1.501 0.99
34_V 60_K 1.451 0.98
11_M 15_K 1.447 0.98
123_E 130_Y 1.446 0.98
35_V 57_S 1.439 0.98
157_L 177_R 1.428 0.98
119_D 169_Q 1.425 0.98
94_R 130_Y 1.418 0.98
83_C 112_L 1.417 0.98
11_M 14_G 1.414 0.98
23_S 85_L 1.401 0.98
48_K 58_P 1.397 0.98
104_V 137_K 1.395 0.98
146_F 180_S 1.392 0.98
155_L 163_P 1.359 0.97
101_S 134_W 1.346 0.97
7_Y 112_L 1.34 0.97
20_L 35_V 1.336 0.97
103_V 107_L 1.33 0.97
126_I 129_Q 1.269 0.95
22_S 112_L 1.242 0.94
129_Q 133_A 1.237 0.94
104_V 136_D 1.231 0.94
89_C 115_G 1.224 0.94
72_I 103_V 1.22 0.94
20_L 149_R 1.215 0.93
7_Y 139_V 1.214 0.93
14_G 17_T 1.213 0.93
98_Y 130_Y 1.209 0.93
34_V 81_I 1.202 0.93
69_F 102_E 1.202 0.93
81_I 84_V 1.191 0.93
94_R 126_I 1.184 0.92
65_N 93_T 1.182 0.92
10_A 154_V 1.18 0.92
67_S 99_E 1.168 0.92
14_G 21_Q 1.158 0.91
74_A 77_E 1.15 0.91
69_F 107_L 1.147 0.91
44_F 52_R 1.129 0.90
70_D 73_R 1.121 0.89
102_E 106_Q 1.119 0.89
96_Q 100_L 1.116 0.89
42_D 46_A 1.115 0.89
65_N 95_Q 1.111 0.89
113_C 131_L 1.108 0.88
32_R 76_H 1.099 0.88
122_G 186_Y 1.094 0.88
13_A 142_K 1.087 0.87
122_G 153_M 1.087 0.87
66_S 71_E 1.087 0.87
74_A 162_R 1.084 0.87
173_G 183_R 1.082 0.87
98_Y 134_W 1.077 0.86
101_S 187_K 1.076 0.86
126_I 130_Y 1.067 0.86
100_L 104_V 1.057 0.85
60_K 71_E 1.05 0.85
72_I 109_I 1.05 0.85
90_Q 127_G 1.047 0.84
90_Q 172_I 1.044 0.84
143_T 151_A 1.037 0.84
73_R 77_E 1.031 0.83
120_F 156_R 1.027 0.83
26_Y 31_M 1.026 0.83
70_D 74_A 1.019 0.82
136_D 183_R 1.017 0.82
37_T 47_G 1.012 0.81
141_L 152_S 1.006 0.81
160_A 164_Y 1.005 0.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1w4rA80.85851000.242Contact Map0.753
2orvA20.92681000.303Contact Map0.737
2j9rA10.90731000.445Contact Map0.661
3e2iA10.93171000.449Contact Map0.678
2b8tA40.98541000.477Contact Map0.68
1xx6A20.89271000.514Contact Map0.715
2orwA20.88291000.61Contact Map0.741
3e1sA10.931798.10.876Contact Map0.463
1w36D20.9512980.881Contact Map0.484
3upuA30.951297.90.883Contact Map0.472
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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