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OPENSEQ.org

YIGA - Uncharacterized protein YigA
UniProt: P23305 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11201
Length: 235 (220)
Sequences: 346
Seq/Len: 1.57

YIGA
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
17_D 33_R 3.142 1.00
38_V 43_V 2.052 0.99
61_A 65_I 1.97 0.98
64_H 69_E 1.957 0.98
20_V 51_V 1.885 0.97
23_Y 30_F 1.77 0.95
101_S 104_D 1.736 0.95
118_L 200_F 1.714 0.94
98_A 103_D 1.666 0.93
36_R 61_A 1.646 0.93
98_A 226_E 1.637 0.92
20_V 31_F 1.593 0.91
21_V 34_N 1.593 0.91
181_V 184_V 1.592 0.91
164_G 170_E 1.572 0.90
30_F 62_R 1.566 0.90
29_E 104_D 1.549 0.89
175_L 199_L 1.508 0.87
51_V 59_A 1.479 0.86
27_N 37_A 1.474 0.86
31_F 42_R 1.453 0.85
21_V 37_A 1.451 0.85
73_A 220_I 1.423 0.83
113_A 116_L 1.418 0.83
17_D 20_V 1.392 0.81
181_V 201_T 1.386 0.81
163_L 200_F 1.381 0.80
125_L 181_V 1.366 0.79
22_D 29_E 1.358 0.79
45_H 54_V 1.351 0.78
45_H 55_E 1.324 0.76
16_D 19_A 1.303 0.75
64_H 81_A 1.3 0.74
44_P 75_L 1.289 0.74
64_H 167_N 1.274 0.72
22_D 26_K 1.27 0.72
20_V 30_F 1.251 0.70
92_L 106_L 1.251 0.70
166_L 182_G 1.241 0.69
64_H 212_Q 1.24 0.69
24_L 30_F 1.226 0.68
56_W 163_L 1.216 0.67
29_E 67_V 1.199 0.66
31_F 55_E 1.197 0.65
73_A 76_M 1.186 0.64
117_G 121_A 1.181 0.64
69_E 73_A 1.181 0.64
54_V 79_A 1.179 0.64
112_W 121_A 1.17 0.63
97_T 201_T 1.163 0.62
44_P 224_L 1.159 0.62
45_H 52_S 1.154 0.61
52_S 57_H 1.149 0.61
18_R 191_S 1.149 0.61
60_R 200_F 1.147 0.61
165_P 210_Q 1.146 0.60
116_L 216_L 1.141 0.60
79_A 83_E 1.14 0.60
79_A 216_L 1.137 0.60
55_E 170_E 1.135 0.59
22_D 199_L 1.121 0.58
27_N 49_G 1.119 0.58
119_A 203_R 1.116 0.57
125_L 194_D 1.11 0.57
56_W 88_R 1.109 0.57
149_E 152_R 1.108 0.57
92_L 115_D 1.105 0.56
21_V 216_L 1.104 0.56
25_I 40_A 1.102 0.56
86_F 207_H 1.093 0.55
43_V 57_H 1.092 0.55
58_M 93_Q 1.087 0.54
102_L 224_L 1.087 0.54
185_A 217_L 1.084 0.54
201_T 218_H 1.08 0.54
38_V 56_W 1.08 0.54
18_R 22_D 1.075 0.53
75_L 196_G 1.073 0.53
23_Y 27_N 1.073 0.53
85_L 208_Y 1.072 0.53
188_M 207_H 1.072 0.53
54_V 182_G 1.071 0.53
76_M 119_A 1.07 0.53
53_L 79_A 1.069 0.53
176_P 199_L 1.064 0.52
94_R 222_L 1.063 0.52
202_S 207_H 1.062 0.52
186_M 205_A 1.061 0.52
20_V 167_N 1.06 0.52
20_V 172_L 1.054 0.51
187_S 221_A 1.054 0.51
45_H 175_L 1.054 0.51
100_S 201_T 1.053 0.51
31_F 46_P 1.049 0.50
71_N 216_L 1.048 0.50
189_L 217_L 1.047 0.50
94_R 216_L 1.046 0.50
200_F 227_L 1.045 0.50
55_E 62_R 1.044 0.50
66_H 80_I 1.042 0.50
174_V 212_Q 1.042 0.50
22_D 51_V 1.042 0.50
85_L 220_I 1.038 0.49
25_I 97_T 1.037 0.49
220_I 228_L 1.029 0.48
162_Y 170_E 1.029 0.48
89_L 223_M 1.028 0.48
47_V 213_G 1.028 0.48
61_A 71_N 1.027 0.48
29_E 59_A 1.022 0.48
188_M 225_P 1.019 0.47
124_R 212_Q 1.016 0.47
199_L 215_Q 1.016 0.47
116_L 123_L 1.01 0.46
58_M 69_E 1.009 0.46
92_L 175_L 1.007 0.46
20_V 24_L 1.005 0.46
114_R 147_S 1.004 0.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3e98A20.97451000.168Contact Map0.232
3bjcA10.961798.50.849Contact Map
3e0yA20.663897.80.874Contact Map0.216
3k2nA20.651197.60.88Contact Map0.297
3ci6A20.659697.50.881Contact Map0.283
3mmhA20.651197.40.884Contact Map0.276
3trcA10.646897.40.884Contact Map0.261
3oovA20.61797.30.887Contact Map0.344
3kshA10.625597.20.888Contact Map0.307
4g3wA10.625597.20.888Contact Map0.344

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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