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OPENSEQ.org
MURI - Glutamate racemase
UniProt: P22634 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11204
Length: 285 (255)
Sequences: 1570
Seq/Len: 6.16
MURI
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
87_L 235_T 3.56 1.00
26_V 40_I 3.356 1.00
47_L 86_A 3.203 1.00
180_L 216_Q 3.105 1.00
52_A 258_A 2.893 1.00
57_A 71_R 2.865 1.00
85_L 88_A 2.826 1.00
39_E 42_H 2.678 1.00
37_Y 49_Y 2.536 1.00
73_V 106_K 2.414 1.00
169_A 210_L 2.264 1.00
211_Q 215_L 2.215 1.00
134_A 139_V 2.104 1.00
234_R 237_W 2.08 1.00
165_M 183_L 2.033 1.00
129_I 156_Q 2.031 1.00
89_V 235_T 2.005 1.00
107_F 111_V 1.976 1.00
40_I 49_Y 1.962 1.00
133_L 200_V 1.961 1.00
57_A 74_A 1.897 1.00
78_A 82_R 1.839 1.00
77_T 106_K 1.812 1.00
145_H 159_M 1.79 1.00
136_R 140_K 1.775 1.00
78_A 256_C 1.751 1.00
43_L 236_A 1.74 1.00
82_R 254_A 1.703 1.00
69_V 102_A 1.665 1.00
139_V 159_M 1.645 1.00
131_G 197_P 1.619 1.00
40_I 235_T 1.617 1.00
87_L 112_V 1.616 1.00
76_V 88_A 1.603 1.00
208_P 228_G 1.586 0.99
160_L 189_P 1.582 0.99
100_L 113_G 1.577 0.99
37_Y 40_I 1.573 0.99
167_E 207_F 1.573 0.99
90_V 100_L 1.567 0.99
129_I 158_E 1.559 0.99
125_T 198_D 1.528 0.99
112_V 238_L 1.52 0.99
125_T 155_C 1.519 0.99
148_I 157_I 1.499 0.99
173_L 176_E 1.495 0.99
119_K 234_R 1.471 0.99
71_R 74_A 1.469 0.99
67_F 71_R 1.469 0.99
162_S 207_F 1.456 0.99
21_R 84_P 1.455 0.99
148_I 201_V 1.434 0.99
25_L 85_L 1.426 0.99
40_I 89_V 1.422 0.99
169_A 207_F 1.414 0.98
68_I 137_G 1.412 0.98
132_L 139_V 1.405 0.98
131_G 190_W 1.404 0.98
176_E 179_S 1.403 0.98
39_E 229_A 1.397 0.98
128_G 154_E 1.391 0.98
143_Y 147_L 1.354 0.98
142_S 145_H 1.353 0.98
52_A 75_I 1.35 0.98
218_L 222_T 1.345 0.98
88_A 109_F 1.34 0.98
184_K 188_R 1.333 0.98
77_T 81_E 1.328 0.97
214_L 224_L 1.324 0.97
125_T 199_T 1.317 0.97
139_V 161_G 1.31 0.97
22_P 86_A 1.296 0.97
86_A 239_L 1.296 0.97
245_D 248_S 1.285 0.97
166_V 207_F 1.275 0.97
164_E 207_F 1.266 0.96
132_L 157_I 1.263 0.96
26_V 37_Y 1.24 0.96
215_L 224_L 1.231 0.95
164_E 167_E 1.205 0.95
127_N 199_T 1.203 0.95
63_K 67_F 1.202 0.95
22_P 47_L 1.201 0.95
128_G 152_A 1.2 0.95
183_L 187_L 1.193 0.94
160_L 186_I 1.184 0.94
55_N 58_F 1.173 0.94
67_F 70_E 1.167 0.93
80_Q 109_F 1.163 0.93
125_T 128_G 1.16 0.93
120_P 230_A 1.152 0.93
191_L 218_L 1.15 0.93
40_I 232_A 1.149 0.93
35_S 208_P 1.148 0.93
76_V 111_V 1.146 0.93
183_L 217_V 1.14 0.92
63_K 71_R 1.13 0.92
37_Y 253_I 1.13 0.92
95_A 116_P 1.125 0.92
234_R 238_L 1.119 0.92
118_I 148_I 1.119 0.92
211_Q 226_D 1.104 0.91
24_V 47_L 1.099 0.91
214_L 217_V 1.094 0.90
227_S 230_A 1.089 0.90
35_S 209_L 1.086 0.90
130_V 155_C 1.082 0.90
82_R 256_C 1.079 0.89
77_T 107_F 1.073 0.89
126_A 223_R 1.072 0.89
183_L 214_L 1.068 0.89
104_R 119_K 1.06 0.88
96_S 100_L 1.057 0.88
164_E 185_R 1.057 0.88
174_H 179_S 1.055 0.88
117_A 121_A 1.041 0.87
73_V 102_A 1.039 0.87
142_S 159_M 1.037 0.87
121_A 198_D 1.034 0.87
104_R 147_L 1.034 0.87
64_S 67_F 1.032 0.86
211_Q 224_L 1.024 0.86
146_E 150_R 1.022 0.86
44_L 236_A 1.021 0.86
219_P 222_T 1.02 0.86
35_S 71_R 1.019 0.85
47_L 239_L 1.017 0.85
67_F 259_M 1.017 0.85
176_E 180_L 1.005 0.84
173_L 178_V 1.004 0.84
200_V 218_L 1.003 0.84
89_V 112_V 1.003 0.84
117_A 120_P 1.003 0.84
144_T 159_M 1.001 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2dwuA30.92981000.29Contact Map0.715
2jfnA10.98251000.303Contact Map0.699
1zuwA30.91581000.306Contact Map0.785
2vvtA20.97541000.317Contact Map0.742
2gzmA40.91581000.337Contact Map0.779
2jfqA20.97541000.343Contact Map0.741
3istA20.92281000.345Contact Map0.75
2ohoA20.92981000.348Contact Map0.778
3outA30.90881000.354Contact Map0.776
2jfzA20.86321000.377Contact Map0.718
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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